Bioactive compounds and functional foods as coadjuvant therapy for thrombosis

Martínez, Juan Pablo Quintal; Campos, Maira Rubí Segura

doi:10.1039/d2fo03171j

Cited by 6 publications

(1 citation statement)

References 102 publications

(160 reference statements)

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“…In fact, over the past few years, a number of structurally diverse plant molecules [ 30 , 31 ] and their derivatives have been found to have potential therapeutic effects [ 32 ], and some of them have been identified as antiviral molecules. In general, different studies have demonstrated the beneficial properties of culinary Mediterranean plants [ 33 , 34 ] and corresponding functional foods [ 35 , 36 , 37 ] with respect to several ailments. Some of them can strengthen the human body’s defenses against viral infections because they interfere with the life cycle of the virus or have beneficial effects on the host immunity [ 38 , 39 , 40 , 41 ], while others such as several steroidal glycosides including ouabain, digitoxin, and digoxin have shown in vitro a direct inhibitory activity against SARS-CoV-2 [ 42 ].…”

Section: Introductionmentioning

confidence: 99%

Interaction of Laurusides 1 and 2 with the 3C-like Protease (Mpro) from Wild-Type and Omicron Variant of SARS-CoV-2: A Molecular Dynamics Study

Autiero

Roviello

2023

IJMS

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Laurus nobilis (bay laurel) is a natural source of biological compounds, and some of its extracts and phytocompounds are also endowed with antiviral activity toward the family of the severe acute respiratory syndrome (SARS)-associated β-coronaviruses. Some glycosidic laurel compounds such as laurusides were proposed as inhibitors of important protein targets of SARS-CoV-2, which clearly recalls their potential as anti-COVID-19 drugs. Due to the frequent genomic variations of the β-coronaviruses and the consequent importance of evaluating a new drug candidate with respect to the variants of the target β-coronavirus, we decided to investigate at an atomistic level the molecular interactions of the potential laurel-derived drugs laurusides 1 and 2 (L01 and L02, respectively) toward a well-conserved and crucial target, the 3C-like protease (Mpro), using the enzymes of both the wild-type of SARS-CoV-2 and of the more recent Omicron variant. Thus, we performed molecular dynamic (MD) simulations of laurusides—SARS-CoV-2 protease complexes to deepen the knowledge on the stability of the interaction and compare the effects of the targeting among the two genomic variants. We found that the Omicron mutation does not significantly impact the lauruside binding and that L02 connects more stably with respect to L01 in the complexes from both variants, even though both compounds prevalently interact within the same binding pocket. Although purely in silico, the current study highlights the potential role of bay laurel phytocompounds in the antiviral and specifically anti-coronavirus research and shows their potential binding toward Mpro, corroborating the important commitment of bay laurel as functional food and disclosing novel scenarios of lauruside-based antiviral therapies.

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Section: Introductionmentioning

confidence: 99%

Interaction of Laurusides 1 and 2 with the 3C-like Protease (Mpro) from Wild-Type and Omicron Variant of SARS-CoV-2: A Molecular Dynamics Study

Autiero

Roviello

2023

IJMS

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Antithrombotic and anticariogenic activity of peptide fractions from cowpea (Vigna unguiculata) protein hydrolysates

Gerónimo‐Alonso,

Ortíz‐Vázquez,

Rodríguez‐Canto

et al. 2024

J Sci Food Agric

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BACKGROUNDProtein‐derived peptide fractions can play a key role in the physiological and metabolic regulation and modulation of the body, which suggests that they could be used as functional ingredients to improve health and to reduce the risk of disease. This work aimed to evaluate the in vitro antithrombotic and anticariogenic bioactivity of hydrolysates and protein fractions obtained from cowpea (Vigna unguiculata) by biocatalysis.RESULTSCowpea protein concentrate was hydrolyzed by sequential action with two enzyme systems, Pepsin‐Pancreatin or Alcalase‐Flavourzyme. There was extensive enzymatic hydrolysis, with degrees of hydrolysis of 34.94% and 81.43% for Pepsin‐Pancreatin and Alcalase‐Flavourzyme, respectively. The degree of hydrolysis for the control treatments, without the addition of the enzymes Pepsin‐Pancreatin and Alcalase‐Flavourzyme was 1.1% and 1.2%, respectively. The hydrolysates were subjected to fractionation by ultrafiltration, with five cut‐off points according to molecular weight (<1, 1–3, 3–5, 5–10 and >10 kDa). The Alcalase‐Flavourzyme hydrolysate led to 100% inhibition of platelet aggregation, while the Pepsin‐Pancreatin hydrolysate showed 77.41% inhibition, but this was approximately 100% in the ultrafiltered fractions. The highest anticariogenic activity was obtained with the Pepsin‐Pancreatin system, with 61.55% and 56.07% for calcium and phosphorus demineralization, respectively.CONCLUSIONHydrolysates and their peptide fractions from Vigna unguiculata exhibited inhibition of platelet aggregation and protection of tooth enamel and have the potential for use in the development of functional products with beneficial health effects. © 2024 Society of Chemical Industry.

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Phenolic profile, cheminformatics, and antiplatelet aggregation activity of orange and purple sweet potato (Ipomoea batatas L.) storage roots

Rodriguez,

Muñoz-Bernal,

Fuentes

et al. 2024

Food Chemistry

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Bioactive compounds and functional foods as coadjuvant therapy for thrombosis

Abstract: Cardiovascular diseases (CVD) are the leading cause of death. The most common cardiovascular pathologies are thromboembolic diseases. The antithrombotic therapy prevents the thrombi formation or dissolves the previously constituted. However,...

Cited by 6 publications

References 102 publications

Interaction of Laurusides 1 and 2 with the 3C-like Protease (Mpro) from Wild-Type and Omicron Variant of SARS-CoV-2: A Molecular Dynamics Study

Interaction of Laurusides 1 and 2 with the 3C-like Protease (Mpro) from Wild-Type and Omicron Variant of SARS-CoV-2: A Molecular Dynamics Study

Antithrombotic and anticariogenic activity of peptide fractions from cowpea (Vigna unguiculata) protein hydrolysates

Phenolic profile, cheminformatics, and antiplatelet aggregation activity of orange and purple sweet potato (Ipomoea batatas L.) storage roots

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