Bioactive compounds, antibiotics and heavy metals: Effects on the intestinal structure and microbiome of monogastric animals – a non-systematic review

Winiarska-Mieczan, Anna; Kwiecień, Małgorzata; Jachimowicz, Karolina; Muszyński, Siemowit; Tomaszewska, Ewa

doi:10.2478/aoas-2022-0057

Cited by 10 publications

(9 citation statements)

References 232 publications

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“…Additionally, algae can have prebiotic effects by promoting the growth of beneficial gut bacteria. This contributes to a healthier gut microbiome, essential for efficient digestion and overall health [54,55]. Algae are also rich in antioxidants, including polyphenols and carotenoids, which help protect digestive tract cells from oxidative damage, maintain gut health, and reduce inflammation, thereby alleviating digestive discomfort [56].…”

Section: Discussionmentioning

confidence: 99%

Nutritional and Antioxidative Benefits of Dietary Macroalgae Supplementation in Weaned Piglets

Czech,

Woś,

Muszyński

et al. 2024

Animals

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This study explores the effects of dietary brown macroalgae (Ascophyllum nodosum) inclusion on digestibility and blood biochemical indices and redox markers in piglets fed diets with varying levels (0%, 0.6% and 1%) of macroalgae from 18 to 64 days of age. Macroalgae significantly influenced lipid profiles, reducing total cholesterol levels (quadratic contrast p = 0.001) and demonstrating an increase in high-density lipoprotein cholesterol levels, particularly with 1% macroalgae inclusion (linear contrast p < 0.001), with a decrease in low-density lipoprotein cholesterol in both macroalgae-supplemented groups (linear contrast p = 0.001). Additionally, macroalgae had a positive impact on the activities of antioxidative enzymes (ferric-reducing ability of plasma, superoxide dismutase, reduced glutathione) and reduced lipid peroxidation products (lipid hydroperoxide, malondialdehyde) in the blood, liver tissue, and intestinal epithelium of the ileum, suggesting enhanced antioxidative defense mechanisms. These changes were dose-dependent; in blood plasma, they exhibited both a linear and quadratic response, while in the tissues, the response was primarily linear. Additionally, an increase in the digestibility of crude fat in macroalgae-supplemented groups was observed (linear contrast p < 0.001), highlighting their potential role in improving nutrient absorption and digestion. The study findings emphasize the health benefits of natural, seaweed-based additives in diets, particularly in managing oxidative stress and improving lipid profiles, and highlight the potential of macroalgae as a natural dietary supplement to improve antioxidant systems and lipid metabolism in piglets.

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Section: Discussionmentioning

confidence: 99%

Nutritional and Antioxidative Benefits of Dietary Macroalgae Supplementation in Weaned Piglets

Czech,

Woś,

Muszyński

et al. 2024

Animals

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“…Among natural food components, compounds with prebiotic activity have a positive effect on the microbiota. This group includes indigestible oligosaccharides, whose positive influence on the structure of the gut microbiota and overall health has been proven in numerous studies [ 2 , 10 , 11 ]. However, recent studies have also shown that polyphenols, which are secondary metabolites produced by plants, exhibit prebiotic properties.…”

Section: The Impact Of Gut Microbiota On Oestrogen Synthesismentioning

confidence: 99%

“…Prebiotics, on the other hand, are food components that positively impact well-being and health by selectively stimulating the growth and/or activity of gut microbiota, thereby also positively influencing the gut structure [ 8 ]. This group includes indigestible oligosaccharides, and their positive effects on gut microbiota structure and health have been demonstrated in numerous studies [ 2 , 9 , 10 ]. However, recent research has shown that polyphenols, which are likely the most important secondary metabolites produced by plants, also exhibit prebiotic properties.…”

Section: Introductionmentioning

confidence: 99%

Polyphenols Influence the Development of Endometrial Cancer by Modulating the Gut Microbiota

Baranowska-Wójcik,

Winiarska-Mieczan,

Olcha

et al. 2024

Nutrients

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Dysbiosis of the microbiota in the gastrointestinal tract can induce the development of gynaecological tumours, particularly in postmenopausal women, by causing DNA damage and alterations in metabolite metabolism. Dysbiosis also complicates cancer treatment by influencing the body’s immune response and disrupting the sensitivity to chemotherapy drugs. Therefore, it is crucial to maintain homeostasis in the gut microbiota through the effective use of food components that affect its structure. Recent studies have shown that polyphenols, which are likely to be the most important secondary metabolites produced by plants, exhibit prebiotic properties. They affect the structure of the gut microbiota and the synthesis of metabolites. In this review, we summarise the current state of knowledge, focusing on the impact of polyphenols on the development of gynaecological tumours, particularly endometrial cancer, and emphasising that polyphenol consumption leads to beneficial modifications in the structure of the gut microbiota.

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“…Prenatal nutrition is important in the healthy physical and mental development of mammals and has long-term effects evident later in life 10 , 11 . ACR is often consumed unknowingly and thus ACR dietary intake is difficult to assess 12 – 14 .…”

Section: Introductionmentioning

confidence: 99%

Maternal acrylamide exposure changes intestinal epithelium, immunolocalization of leptin and ghrelin and their receptors, and gut barrier in weaned offspring

Muszyński

Hułas-Stasiak

Dobrowolski

et al. 2023

Sci Rep

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Acrylamide (ACR) is an amide formed as a byproduct in many heat-processed starchy-rich foods. In utero ACR exposure has been associated with restricted fetal growth, but its effects of postnatal functional development of small intestine is completely unknown. The current study investigated the time- and segment-dependent effects of prenatal ACR exposure on morphological and functional development of small intestine in weaned rat offspring. Four groups of pregnant female Wistar rats were exposed to ACR (3 mg/kg b.w./day) for 0, 5, 10 and 15 days during pregnancy. Basal intestinal morphology, immunolocalization of gut hormones responsible for food intake and proteins of intestinal barrier, activity of the intestinal brush border disaccharidases, apoptosis and proliferation in intestinal mucosa were analyzed in offspring at weaning (postnatal day 21). The results showed that in utero ACR exposure disturbs offspring gut structural and functional postnatal development in a time- and segment-depended manner and even a short prenatal exposure to ACR resulted in changes in intestinal morphology, immunolocalization of leptin and ghrelin and their receptors, barrier function, activity of gut enzymes and upregulation of apoptosis and proliferation. In conclusion, prenatal ACR exposure disturbed the proper postnatal development of small intestine.

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Bioactive compounds, antibiotics and heavy metals: Effects on the intestinal structure and microbiome of monogastric animals – a non-systematic review

Cited by 10 publications

References 232 publications

Nutritional and Antioxidative Benefits of Dietary Macroalgae Supplementation in Weaned Piglets

Nutritional and Antioxidative Benefits of Dietary Macroalgae Supplementation in Weaned Piglets

Polyphenols Influence the Development of Endometrial Cancer by Modulating the Gut Microbiota

Maternal acrylamide exposure changes intestinal epithelium, immunolocalization of leptin and ghrelin and their receptors, and gut barrier in weaned offspring

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