Bioactive Compounds, Antioxidant Activity, and Biological Effects of European Cranberry (Vaccinium oxycoccos)

Jurí­ková, Tűnde; Škrovánková, Soňa; Mlček, Jiří­; Balla, Štefan; Snopek, Lukáš

doi:10.3390/molecules24010024

Cited by 89 publications

(78 citation statements)

References 101 publications

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“…The major phenol in M. rhodantha and M. spinosissima was gentisic acid. Gentisic acid was discovered in a few species such as Momordica charantia leaves (12.75 mg g −1 ) [23] and Vaccinium oxyccocos fruit (0.3 mg 100 g −1 ) [24] and is rare in general. Gentisic acid is a strong anti-oxidant and has important health benefits [25,26].…”

Section: Discussionmentioning

confidence: 99%

Mammillaria Species—Polyphenols Studies and Anti-Cancer, Anti-Oxidant, and Anti-Bacterial Activities

et al. 2019

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Discovering new natural resources of polyphenols is the aim of many recent studies in the field of natural product research. This study tentatively investigated the polyphenols profile of the stems of seven Mammillaria species (M. rhodantha, M. spinosissima, M. hahniana, M. crucigera, M. candida, M. albilanata, and M. muehlenpfordtii) using high performance liquid chromatography with DAD detector (HPLC-DAD) method. Furthermore, the anti-cancer, anti-oxidant, and anti-bacterial potentials of these extracts as well as major identified phenols were explored. The HPLC-DAD study confirmed the availability of six phenolic acids, including gentisic acid, chlorogenic acid, caffeic acid, protocatechuic acid, sinapic acid, and p-hydroxybenzoic acid. The dominant compounds were: gentisic acid in M. rhodantha and M. spinosissima; chlorogenic acid in M. muehlenpfordtii, M. crucigera, and M. rhodantha; and caffeic acid in M. rhodantha, M. crucigera, and M. spinosissima. Stems of Mammillaria sp. showed antiproliferative effects against HeLa, MCF-7, and Jurkat cells. In HeLa and MCF-7 cells, the best antiproliferative activities were found in the treatments with M. rhodantha, M. spinosissima, and M. muehlenpfordtii. The apoptotic assay of M. rhodantha, M. spinosissima, and M. muehlenpfordtii showed accumulation of necrotic cells in the early and late apoptotic phase. M. rhodantha, M. spinosissima, and M. muehlenpfordtii showed the highest anti-oxidant activities using 2,2-diphenyl-1-picrylhydrazyl (DPPH), β-carotene bleaching, and ferric reducing anti-oxidant power (FRAP) assays. M. rhodantha was the best source of antioxidants. Mammillaria sp. showed moderate anti-bacterial effects against bacteria and the highest effects were found using the extracts of M. rhodantha, M. spinosissima, M. crucigera and M. muehlenpfordtii against most bacteria. The anti-bacterial activities were attributed to other phenolic compounds (e.g., chlorogenic acid) than gentisic acid, which was not active against most bacteria. Mammillaria sp. could be considered to be an important natural source of phenolic acids with anti-cancer, anti-bacterial, and anti-oxidant activities.

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Section: Discussionmentioning

confidence: 99%

Mammillaria Species—Polyphenols Studies and Anti-Cancer, Anti-Oxidant, and Anti-Bacterial Activities

et al. 2019

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“…The conducted studies revealed differences between the varieties of snowball tree in the content of total sugars. Studies by Shchetilina et al (2016) 2010, Kucharska et al, (2015), Jurikova et al (2019) proved that a particularly important role of pectins is the prevention of many types of cancers. Pectin solutions have been shown to have antibacterial properties (Skrovankova et al, 2015;Ceylan et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

“…One of the important glycosides of snowball tree is iridoid viburnin. Česonienė et al (2010), Skrovankova et al (2015), Tsuchiya (2015), Jurikova et al (2019) demonstrated that in pharmacy on the basis of iridoids of natural origin, preparations of cardiovascular and antispasmodic group can be produced, and the results of recent studies (Stępień, et al, 2010;Kucharska et al, 2015;Skrovankova et al, 2015) have revealed its antitumour activity. Furthermore, (Kraujalytė et al, 2013;Kucharska et al, 2015;Konarska & Domaciuk, 2018;Jurikova et al, 2019) have confirmed that biologically active substances of V. opulus manifest hemostatic, antiseptic, tonic effect on the human body, and also increase the tone of the uterine muscles and prevent the appearance of varicose veins.…”

Section: Discussionmentioning

confidence: 99%

“…Elliott, amelanchier Amelanchier canadensis (L.) Medik., sea buckthorn Hippophae rhamnoides L., quince Cydonia oblonga Mill., snowball tree Viburnum opulus L., dogwood Cornus mas L. and others (Golubieva et al, 2016;Sіzaуа et al, 2017;Moskalets et al, 2019). Their raw materials are a source of vitamins, minerals, dietary fiber and other vital nutrients, necessary for normal metabolic processes in the human body (Skrovankova et al, 2015;Jurikova et al, 2019). A promising pro-duct of recycling is the fruits of snowball tree (Viburnum opulus L.), which contain monosaccharides, pectic substances, organic acids, vitamins (С, Р, Е, К), carotenoids, bioflavonoids, glycosides, antioxidants, bioavailable complexes of macro-and microelements, etc.…”

Section: Introductionmentioning

confidence: 99%

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Fruits of new selection forms and varieties of snowball tree for manufacture of products of therapeutic and prophylactic purpose

Москалец

Vovkohon

et al. 2019

Regul. Mech. Biosyst.

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The paper presents the results of the comparative assessment of varieties and selected breeding forms of the snowball tree (Viburnum opulus L., Adoxaceae). The article presents the biochemical composition, marketable and taste qualities of fruits of varieties and elite forms of the snowball tree of regular selection of the Institute of Horticulture of the NAAS and its network, grown under conditions of the Central part of the Forest-Steppe of Ukraine. We selected the sources of specific economic and valuable features: large-fruits (weight of the fruit of 1.24–1.80 g, weight of bunch of 109–126 g – Velykoplidna, Ania, Uliana, ЕF-3-10-2010), high taste qualities – degustation evaluation of 8.8–9.0 points and chemical composition of fruits (EF-5-12-2012, EF-3-10-2010, Bagriana, Koralova). The study revealed that the fruits of some selection samples are promising raw materials for production of food products and ingredients of functional purpose, including syrups, mors, juices (varieties Kоrаlоvа, Bаhrianа, Аnia, Uliana, ЕF-3-10-2010, ЕF-5-12-2012, ЕF-7-31-12 with sugar-acid index of 4.86–7.63 and juiciness of the fruit of 4.86–7.63%); jelly, marmalade (Bаhrianа, Аnia, Kоrаlоvа, ЕF-3-10-2010, which have increased content of pectic substances – 9.1–13.0 mg/kg and Р-active compounds – 740–950 mg%); powdered food additives (Kоrаlоvа, ЕF-3-10-2010, ЕF-5-12-2012, ЕF-7-31-12); manufacturing pharmaceuticals (ЕF-2-56-13). Consumption of these products reduces the risk of diet-related diseases, preventing deficiency and replenishing nutrients in the human body, thus preserving and improving health due to the presence of physiologically functional ingredients in their composition. The modern food industry is paying more attention to healthy food with a balanced composition of nutrients, including functional products. Today the snowball tree is a nichе plant both in Ukraine and in the world. According to national scientists and market analysts, today some important factors of the cultivation expediency of snowball tree fruits can be distinguished. The weather and climate and soil conditions in Ukraine are quite favourable for cultivation of this plant. The creation of raw material zones would allow the population to be provided with functional products in sufficient quantity, and, if necessary, allow this plant to be cultivated for export.

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“…Application of antioxidants of natural origin (mainly PFCs), as CAS, in cosmetic products (products for skin protection from the OS, for skin care after sun exposure, for prevention and anti‐ageing products) is regarded as justified and is also present in actual dermatological practice and skin care. PFCs can be found in many plants, as well as in the investigated wild apple fruit . This PFCs (phenols, flavonoids, tannins and anthocyanins) may directly ‘scavenge’ free radicals caused by the OS, demonstrating a high affinity for the reactive oxygen species‐ROS, can inhibit the formation of new ROS, activate antioxidant enzymes, chelate prooxidant metal ions and neutralize free radicals.…”

Section: Introductionmentioning

confidence: 99%

Stability, antioxidant activity, in vivo safety and efficacy of creams with standardized wild apple fruit extract: a comparison of conventional and biodegradable emulsifiers

Nešić

Stojiljković²,

Savić

et al. 2019

Intern J of Cosmetic Sci

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Objective The aim of the study was in vitro and in vivo characterization of cosmetic cream with 6% of standardized wild apple fruit extract, stabilized by conventional non‐ionic emulsifier‐CEW, in order to determine the influence of emulsifiers (conventional vs. biodegradable) on the characteristics of creams and their effects on the skin. Methods Organoleptic and physico‐chemical (pH values and electrical conductivity) analysis was performed, determination of fruit acids‐FAs content (using HPLC analysis) and estimation of its antioxidant activity‐AA (using DPPH test) during 180 days. In vivo study included following examinations: screening of safety profile (after creams application under occlusion during 24 h at human skin); skin moisturizing potential, transepidermal water loss‐TEWL, skin pH after 28 days of cream application and hypopigmentation efficacy 7 days of cream application at artificially induced skin hyperpigmentation. Results Investigated cosmetic cream‐CEW showed satisfactory organoleptic, physico‐chemical characteristics, stability, FAs content (0.13%) and AA (19.25 ± 0.67 %RSC) after preparation, which remained unchanged over the study period. In vivo investigation revealed absence of skin irritation after CEW's application under occlusion. An increase of skin moisturization (after 14 days ΔEC was 18.52 ± 11.51 and after 28 days of applications 16.52 ± 9.36) during 28 day‐study, with unchanged TEWL and skin pH values was shown. Decrease of melanin index was revealed, too (after 7 days ΔMI was −31.40 ± 16.50). Conclusion Cosmetic cream stabilized by conventional emulsifier showed better antioxidant potential and weaker moisturizing and hypopigmentation effects related to the cream with same composition but stabilized by biodegradable emulsifiers. Based on all mentioned above, investigated cosmetic cream might be considered for potential use as modern, stable, safe and efficient cosmetic product in the prevention and/or treatment of oxidative stress‐related skin changes and/or damages, for moisturization of dry, even irritated skin as well as for lightening of hyperpigmented skin. Résumé OBJECTIFLe but de l’étude était la caractérisation in vitro et in vivo d'une crème cosmétique contenant 6 % d'extrait normalisé de pomme sauvage, stabilisée par un émulsifiant non ionique conventionnel‐CEW, afin de déterminer l'influence des émulsifiants (conventionnels vs biodégradables) sur les caractéristiques des crèmes et les effets sur la peau. MÉTHODES Des analyses organoleptiques et physico‐chimiques (pH et conductivité électrique) ont été effectuées, la détermination de la teneur en acides de fruits et en acides gras polyinsaturés (par CLHP), et l'estimation de sa teneur en activité antioxydante (AA) (à l'aide du test DPPH) pendant 180 jours. L’étude in vivo comprenait les examens suivants : dépistage du profil d'innocuité (après application de crèmes sous occlusion pendant 24 h sur la peau humaine); potentiel d'hydratation de la peau, perte d'eau transépidermique (PETE), pH de la peau après 28 j...

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Bioactive Compounds, Antioxidant Activity, and Biological Effects of European Cranberry (Vaccinium oxycoccos)

Cited by 89 publications

References 101 publications

Mammillaria Species—Polyphenols Studies and Anti-Cancer, Anti-Oxidant, and Anti-Bacterial Activities

Mammillaria Species—Polyphenols Studies and Anti-Cancer, Anti-Oxidant, and Anti-Bacterial Activities

Fruits of new selection forms and varieties of snowball tree for manufacture of products of therapeutic and prophylactic purpose

Stability, antioxidant activity, in vivo safety and efficacy of creams with standardized wild apple fruit extract: a comparison of conventional and biodegradable emulsifiers

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