Bioactive compounds, aucubin and acteoside, in plantain (Plantago lanceolata L.) and their effect on in vitro rumen fermentation

Navarrete, Soledad; Kemp, Peter; Pain, S. J.; Back, P. J.

doi:10.1016/j.anifeedsci.2016.10.008

Cited by 69 publications

(58 citation statements)

References 30 publications

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“…It is possible that some of the increased urine output elicited by plantain arises from phytochemicals that are unique to this species. The most common phytochemicals explored in the literature are two iridoid glycosides, aucubin and catalpol, and a phenylpropanoid glycoside called acteoside ( Navarrete et al, 2016 ). A larger difference of urinary volume between plantain and ryegrass was observed by Box et al (2017) in dairy cows in late lactation compared with early lactation, which coincides with when the concentrations of aucubin and acteoside were greatest.…”

Section: Discussionmentioning

confidence: 99%

Plantain (Plantago lanceolata) reduces the environmental impact of farmed red deer (Cervus elaphus)1

Beck

Garrett

Thompson

et al. 2020

Translational Animal Science

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The objective of this study was to evaluate the effect of plantain (Plantago lanceolata L.) on water dynamics and balance, as well as nitrogen (N) excretion by red deer (Cervus elaphus L.) as a potential forage tool to reduce negative environmental impacts. This experiment used a cross-over design with red deer (n = 8) in metabolism crates to determine how fresh cut herbage diets of either plantain or ryegrass (Lolium perenne L.) compared in terms of dry matter intake (DMI), diet digestibility, water dynamics, and N dynamics. Deer consuming plantain had greater water intake from herbage (P & 0.01) compared with ryegrass. Additionally, when fed plantain, deer had greater water excretion from urine (P & 0.01; 69.4%), feces (P & 0.01; 29.4%), and thus total water excretion (P & 0.01; 61.7%) than when fed ryegrass. When consuming plantain, deer had greater DMI (P = 0.02; +11.2%) and fecal output (P & 0.01; +36.8%), and lower apparent dry matter digestibility (DMD; P = 0.03; -8.3%) compared with ryegrass. Plantain (15.9%) contained 30% less crude protein than ryegrass (22.8%), so that even with the greater DMI of plantain, plantain had lower (P & 0.01; -23%) N intake (g/d). Deer consuming plantain had lower urine N concentration (P & 0.01) than when consuming ryegrass. Additionally, deer consuming plantain had much less daily urine N (P & 0.01; -34.9%) excretions. Our results indicate deer fed plantain had greater DMI, ingested more water, and excreted more water than those consuming ryegrass, with lower urinary N concentration and lesser daily urine N excretion. Thus, we conclude that offering red deer plantain may reduce the environmental impact associated with urinary N output, such as nitrate leaching or N2O emissions to the atmosphere.

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Section: Discussionmentioning

confidence: 99%

Plantain (Plantago lanceolata) reduces the environmental impact of farmed red deer (Cervus elaphus)1

Beck

Garrett

Thompson

et al. 2020

Translational Animal Science

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“…Terpenes can act as plant defence chemicals and in the example of aucubin, which is found in plantain species, it has been shown to be associated with reduced growth of fungal pathogen Diaporthe adunca and reduced feeding and growth of beet armyworm (Spodoptera exigua) (Biere et al 2004). The impact of aucubin-containing plantain has also been associated with N metabolism of microbia, reducing the rate of ammonia production in both soils (Carlton et al 2019;de Klein et al 2019) and rumen fluid (Navarrete et al 2016). In P. lanceolata the aucubin levels are typically greater than catalpol (Box et al 2019) though concentrations of the different metabolites vary greatly as they are dependent on season (Clemensen et al 2017;Box et al 2019), and level of herbivory and association with mychorriza (Wang et al 2015;Clemensen et al 2018).…”

Section: Plant Secondary Metabolitesmentioning

confidence: 99%

Can alternative forages substantially reduce N leaching? findings from a review and associated modelling

Bryant

Snow

Shorten

et al. 2019

New Zealand Journal of Agricultural Research

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Nitrogen (N) leaching losses from grazed pasture systems pose a risk to the environment with mitigation strategies urgently required to achieve regulatory limits. There has been increased interest in alternative forages to manipulate excretion of urinary-N of livestock. This review summarises research on key forage attributes which affect the pattern of urine-N excretion. The literature showed an opportunity to alter both N concentration and moisture concentration of forages to reduce urine patch N loading. Complementary mitigations of extending the grazing rotation and reducing fertiliser were tested in simulations in addition to a diuresis effect on nitrate leaching in pastoral dairy systems. Findings suggested that forage species alone could not substantially reduce (by more than 20%) nitrate leaching. Combining all forage, management and systems-based solutions led to the greatest reductions in nitrate leaching, 59 and 31% for Waikato and Canterbury. Nonetheless, reductions in N loss came at the expense of pasture productivity which will likely affect profitability and farmer adoption of this suite of solutions in the absence of other drivers. The role of plant secondary metabolites in microbial dynamics has implications on N recycling in soil and rumen environments and this was identified as an area for further research.

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“…From the above findings, 1.74 percent of verbascoside obtained from Iraqi P. lanceoleta L. in first growing season considered as high percent and compatible to that highlighted in British pharmacopeia "P. lanceoleta L. contains 1.5 percent of verbascoside as minimum", while another study showed that the P. lanceolate L. cultivated in New Zealand showed an increment in the concentration of verbascoside from 2.36 to 3.54 percent in the first growing season, which is higher than that obtained from Iraqi plant; the same study showed an increment in aucubin concentration from 0.178 to 0.380 percent which is compatible to that obtained from Iraqi plant (0.240 percent) [13].…”

Section: Discussionmentioning

confidence: 52%

“…Iridoid glycosides that found in the ribwort plantain considered as a group of the most important secondary metabolites, and also as chemotaxonomic markers for Plantago spp [12]; aucubin is one of the major molecules found in ribwort plantain; the aucubin concentration in ribwort plantain becomes higher as the leaves get older [13]. It plays many important roles in the medicinal effects of ribwort plantain that include its hepatoprotective [14], pancreasprotective [15], antiarthritic [16], spasmolytic [17], collagen synthesis promoting effects [18], neuroprotective and antiatherogenic [19]; both aucubin and catalpol ( fig.…”

Section: Introductionmentioning

confidence: 99%

Determination, Isolation, and Identification of Aucubin and Verbascoside in the Leaves of Iraqi Plantago Lancoleta L. Using Different Detecting Methods

Khalaf

Abbas

Tawfeeq

et al. 2018

Int J Pharm Pharm Sci

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Objective: Plantago lanceoleta L. (ribwort plantain) is one of the important medicinal herbs which is widespread fortune available in Iraq, that have a wide range of medicinal properties. The aim of this work was to determine, isolate and identify verbascoside and aucubin in Iraqi P. lanceoleta L. by using different chromatographic and spectrometric methods. Methods: Verbascoside and aucubin were isolated and quantified by preparative TLC, and then they were determined by the high-performance thin-layer chromatography (HPTLC) fingerprinting. Aucubin and catalpol in the plant extract were analyzed by liquid chromatography-mass spectrometry (LC-MS); aucubin and verbascoside that isolated from the plant sample were examined by fourier-transform infrared spectroscopy (FT-IR) and LC-MS, respectively. Results: The result showed that the Iraqi P. lanceoleta L. contains 1.74 percent (verbascoside) and 0.24 percent (aucubin) of dry powdered leaves. Each TLC-isolated compound showed a single spot on the HPTLC plate, which give an idea about the purity of the isolated compound. Aucubin (with catalpol) and verbascoside both are detected by LC-MS in different ionization mode. Many functional groups were identified in the TLC-isolated aucubin by FT-IR. Conclusion: The Iraqi P. lanceoleta L. showed a high content of verbasoside, and it is a very rich source for this compound, which can be easily isolated by TLC and subjected to many pharmacological studies. The extract of the young leaves of this plant gave a little amount of aucubin, and it is easy to obtain a higher content from the older leaves.

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Bioactive compounds, aucubin and acteoside, in plantain (Plantago lanceolata L.) and their effect on in vitro rumen fermentation

Cited by 69 publications

References 30 publications

Plantain (Plantago lanceolata) reduces the environmental impact of farmed red deer (Cervus elaphus)1

Plantain (Plantago lanceolata) reduces the environmental impact of farmed red deer (Cervus elaphus)1

Can alternative forages substantially reduce N leaching? findings from a review and associated modelling

Determination, Isolation, and Identification of Aucubin and Verbascoside in the Leaves of Iraqi Plantago Lancoleta L. Using Different Detecting Methods

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