Bioactive Compounds for the Treatment of Renal Disease

Ko, In Kap; Yoo, James J.

doi:10.3349/ymj.2018.59.9.1015

Cited by 11 publications

(7 citation statements)

References 106 publications

(134 reference statements)

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“…There are many non-nutritional bioactive compounds that provide protective and regenerative effects for the kidneys, and which may be used for the treatment of renal disease [132]. However, we do not include possible interactions and synergies of nutritional interventions with non-nutritional bioactive compounds on microbiota in the present review, which focuses on the role of dietary components.…”

Section: Other Diet Componentsmentioning

confidence: 99%

Dietary Components That May Influence the Disturbed Gut Microbiota in Chronic Kidney Disease

et al. 2019

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Gut microbiota imbalance is common in patients with chronic kidney disease (CKD) and associates with factors such as increased circulating levels of gut-derived uremic toxins, inflammation, and oxidative stress, which are linked to cardiovascular disease and increased morbimortality. Different nutritional strategies have been proposed to modulate gut microbiota, and could potentially be used to reduce dysbiosis in CKD. Nutrients like proteins, fibers, probiotics, and synbiotics are important determinants of the composition of gut microbiota and specific bioactive compounds such as polyphenols present in nuts, berries. and fruits, and curcumin, may also play a key role in this regard. However, so far, there are few studies on dietary components influencing the gut microbiota in CKD, and it is therefore not possible to conclude which nutrients should be prioritized in the diet of patients with CKD. In this review, we discuss some nutrients, diet patterns and bioactive compounds that may be involved in the modulation of gut microbiota in CKD and provide the background and rationale for studies exploring whether nutritional interventions with these dietary components could be used to alleviate the gut dysbiosis in patients with CKD.

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Section: Other Diet Componentsmentioning

confidence: 99%

Dietary Components That May Influence the Disturbed Gut Microbiota in Chronic Kidney Disease

et al. 2019

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“… 2 Acute kidney injury (AKI), a common and severe complication of sepsis, is characterized by sudden or chronic renal dysfunction, 3 and severe sepsis accounts for about 50% of all AKI cases. 4 5 …”

Section: Introductionmentioning

confidence: 99%

Long Non-Coding RNA RMRP Contributes to Sepsis-Induced Acute Kidney Injury

et al. 2021

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Purpose This study aimed to explore the role of the long non-coding RNA (lncRNA) RNA component of mitochondrial RNAase P (RMRP) in sepsis-induced acute kidney injury (AKI). Materials and Methods Venous blood was collected from septic patients and healthy people. C57BL/6 mice who underwent cecal ligation and puncture (CLP) were used as in vivo models of septic AKI. Lipopolysaccharide (LPS)-induced HK-2 cells were employed as in vitro models of AKI. Flow cytometry analysis was conducted to detect cell apoptosis. Enzyme-linked immunosorbent assay and Western blot assays were used to detect levels of pro-inflammatory cytokines. Results RMRP was upregulated in sera from patients with AKI and in LPS-induced cells. Knockdown of RMRP inhibited cell apoptosis and reduced production of inflammatory factors in LPS-induced cells, as well as alleviated AKI in CLP mice. RMRP facilitated inflammation by activating NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome. We found that microRNA 206 (miR-206) binds with and is negatively regulated by RMRP: miR-206 directly targets the 3′ untranslated region of DEAD-box helicase 5 (DDX5) and negatively regulates DDX5 expression. By binding with miR-206, RMRP upregulated DDX5 expression. Rescue assays revealed that overexpression of DDX5 counteracted the effect of RMRP inhibition on cell apoptosis and inflammatory response in LPS-induced cells. Conclusion The lncRNA RMRP contributes to sepsis-induced AKI through upregulation of DDX5 in a miR-206 dependent manner and through activation of NLRP3 inflammasome. This novel discovery may provide a potential strategy for treating AKI.

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“…The subject of the study are biologically active compounds that, when added to solutions, can minimize transplant-related complications. These include hormones, trophic factors, minocycline (p38MAPK inhibitor), antioxidants (vitamin C, vitamin E, N -acetylcysteine, coenzyme Q10), micronutrients (zinc, selenium), which can potentially affect organ regeneration [ 1 , 2 , 3 ]. Numerous studies confirm the protective effect of hormones and trophic factors on the ischemic kidney.…”

Section: Introductionmentioning

confidence: 99%

The Role of Hormones and Trophic Factors as Components of Preservation Solutions in Protection of Renal Function before Transplantation: A Review of the Literature

Ostróżka-Cieślik

Dolińska

2020

Molecules

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Transplantation is currently a routine method for treating end-stage organ failure. In recent years, there has been some progress in the development of an optimal composition of organ preservation solutions, improving the vital functions of the organ and allowing to extend its storage period until implantation into the recipient. Optimizations are mostly based on commercial solutions, routinely used to store grafts intended for transplantation. The paper reviews hormones with a potential nephroprotective effect, which were used to modify the composition of renal perfusion and preservation solutions. Their effectiveness as ingredients of preservation solutions was analysed based on a literature review. Hormones and trophic factors are innovative preservation solution supplements. They have a pleiotropic effect and affect normal renal function. The expression of receptors for melatonin, prolactin, thyrotropin, corticotropin, prostaglandin E1 and trophic factors was confirmed in the kidneys, which suggests that they are a promising therapeutic target for renal IR (ischemia-reperfusion) injury. They can have anti-inflammatory, antioxidant and anti-apoptotic effects, limiting IR injury.

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Bioactive Compounds for the Treatment of Renal Disease

Cited by 11 publications

References 106 publications

Dietary Components That May Influence the Disturbed Gut Microbiota in Chronic Kidney Disease

Dietary Components That May Influence the Disturbed Gut Microbiota in Chronic Kidney Disease

Long Non-Coding RNA RMRP Contributes to Sepsis-Induced Acute Kidney Injury

The Role of Hormones and Trophic Factors as Components of Preservation Solutions in Protection of Renal Function before Transplantation: A Review of the Literature

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