Bioactive compounds fractionated from endophyte  Streptomyces  SUK 08 with promising  ex-vivo  antimalarial activity

Zin, Noraziah Mohamad; Remali, Juwairiah; Nasrom, Mohd Nazir; Ishak, Shafariatul Akmar; Baba, Mohd Shukri; Jalil, Juriyati

doi:10.1016/j.apjtb.2017.10.006

Cited by 6 publications

(3 citation statements)

References 28 publications

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“…Terrestrial Actinobacteria have several antimicrobial capabilities, including three active compounds determined as 2,3-heptanedione, butyl propyl ester and cyclohexane with an antimalarial activity isolated from Streptomyces SUK 08 [ 24 ].…”

Section: Microbial Ecology Of Actinobacteriamentioning

confidence: 99%

Biodiversity of Secondary Metabolites Compounds Isolated from Phylum Actinobacteria and Its Therapeutic Applications

et al. 2021

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The current review aims to summarise the biodiversity and biosynthesis of novel secondary metabolites compounds, of the phylum Actinobacteria and the diverse range of secondary metabolites produced that vary depending on its ecological environments they inhabit. Actinobacteria creates a wide range of bioactive substances that can be of great value to public health and the pharmaceutical industry. The literature analysis process for this review was conducted using the VOSviewer software tool to visualise the bibliometric networks of the most relevant databases from the Scopus database in the period between 2010 and 22 March 2021. Screening and exploring the available literature relating to the extreme environments and ecosystems that Actinobacteria inhabit aims to identify new strains of this major microorganism class, producing unique novel bioactive compounds. The knowledge gained from these studies is intended to encourage scientists in the natural product discovery field to identify and characterise novel strains containing various bioactive gene clusters with potential clinical applications. It is evident that Actinobacteria adapted to survive in extreme environments represent an important source of a wide range of bioactive compounds. Actinobacteria have a large number of secondary metabolite biosynthetic gene clusters. They can synthesise thousands of subordinate metabolites with different biological actions such as anti-bacterial, anti-parasitic, anti-fungal, anti-virus, anti-cancer and growth-promoting compounds. These are highly significant economically due to their potential applications in the food, nutrition and health industries and thus support our communities’ well-being.

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Section: Microbial Ecology Of Actinobacteriamentioning

confidence: 99%

Biodiversity of Secondary Metabolites Compounds Isolated from Phylum Actinobacteria and Its Therapeutic Applications

et al. 2021

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“…Endophyte isolated was named as MF31b11. Since an endophyte can produce a complex mixture of compounds, it becomes interesting to extract bioactive compounds using organic solvents in increasing order of polarity ( 21 , 41 ). Overall, microbial metabolites released into the liquid culture medium by the endophytic fungus are often extracted with DCM and EtAc ( 21 , 42 , 43 ).…”

Section: Discussionmentioning

confidence: 99%

Endophytic Fungus Isolated From Achyrocline satureioides Exhibits Selective Antiglioma Activity—The Role of Sch-642305

et al. 2018

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Glioblastoma is the most devastating primary brain tumor. Current treatment is palliative, making necessary the development of new therapeutic strategies to offer alternatives to patients. Therefore, endophytes represent an interesting source of natural metabolites with anticancer potential. These microorganisms reside in tissues of living plants and act to improve their growth. Evidence revealed that several medicinal plants are colonized by endophytic fungi producer of antitumor metabolites. Achyrocline satureioides is a Brazilian medicinal plant characterized by its properties against gastrointestinal disturbances, anticancer and antioxidant effects. However, there are no reports describing the endophytic composition of A. satureioides. The present study proposes the isolation of endophytic fungus from A. satureioides, extract preparation, phytochemical characterization and evaluation of its antiglioma potential. Our data showed that crude extracts of endophyte decreased glioma viability with IC50 values of 1.60–1.63 μg/mL to eDCM (dichloromethane extract) and 37.30–55.12 μg/mL to eEtAc (ethyl acetate extract), respectively. Crude extracts induced cell death by apoptosis with modulation of redox status. In order to bioprospect anticancer metabolites, endophytic fungus extracts were subjected to guided fractionation and purification yielded five fractions of each extract. Six of ten fractions showed selective antiproliferative activity against glioma cells, with IC50 values ranged from 0.95 to 131.3 μg/mL. F3DCM (from eDCM) and F3EtAc (from eEtAc) fractions promoted C6 glioma toxicity with IC50 of 1.0 and 27.05 μg/mL, respectively. F3EtAc fraction induced late apoptosis and arrest in G2/M stage, while F3DCM promoted apoptosis with arrest in Sub-G1 phase. Moreover, F3DCM increased antioxidant defense and decreased ROS production. Additionally, F3DCM showed no cytotoxic activity against astrocytes, revealing selective effect. Based on promising potential of F3DCM, we identified the production of Sch-642305, a lactone, which showed antiproliferative properties with IC50 values of 1.1 and 7.6 μg/mL to C6 and U138MG gliomas, respectively. Sch-642305 promoted arrest on cell cycle in G2/M inducing apoptosis. Furthermore, this lactone decreased glioma cell migration and modulated redox status, increasing superoxide dismutase and catalase activities and enhancing sulfhydryl content, consequently suppressing reactive species of oxygen generation. Taken together, these results indicate that metabolites produced by endophytic fungus isolated from A. satureioides have therapeutic potential as antiglioma agent.

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“…Streptomyces and Micromonospora are the dominant genera and have been acknowledged as valuable resources for antibiotics as well as other bioactive metabolites, such as Munumbicin D, produced by Streptomyces NRRL 30562, and coronamycin, derived from Streptomyces sp. MSU-2110 [ 37 ]. Numerous species of endophytic microbes still need to be explored and identified.…”

Section: The Concept and Types Of Endophytesmentioning

confidence: 99%

The Multifunctions and Future Prospects of Endophytes and Their Metabolites in Plant Disease Management

et al. 2022

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Endophytes represent a ubiquitous and magical world in plants. Almost all plant species studied by different researchers have been found to harbor one or more endophytes, which protect host plants from pathogen invasion and from adverse environmental conditions. They produce various metabolites that can directly inhibit the growth of pathogens and even promote the growth and development of the host plants. In this review, we focus on the biological control of plant diseases, aiming to elucidate the contribution and key roles of endophytes and their metabolites in this field with the latest research information. Metabolites synthesized by endophytes are part of plant disease management, and the application of endophyte metabolites to induce plant resistance is very promising. Furthermore, multi-omics should be more fully utilized in plant–microbe research, especially in mining novel bioactive metabolites. We believe that the utilization of endophytes and their metabolites for plant disease management is a meaningful and promising research direction that can lead to new breakthroughs in the development of more effective and ecosystem-friendly insecticides and fungicides in modern agriculture.

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Bioactive compounds fractionated from endophyte Streptomyces SUK 08 with promising ex-vivo antimalarial activity

Cited by 6 publications

References 28 publications

Biodiversity of Secondary Metabolites Compounds Isolated from Phylum Actinobacteria and Its Therapeutic Applications

Biodiversity of Secondary Metabolites Compounds Isolated from Phylum Actinobacteria and Its Therapeutic Applications

Endophytic Fungus Isolated From Achyrocline satureioides Exhibits Selective Antiglioma Activity—The Role of Sch-642305

The Multifunctions and Future Prospects of Endophytes and Their Metabolites in Plant Disease Management

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