Bioactive compounds from Aspergillus niger extract enhance the antioxidant activity and prevent the genotoxicity in aflatoxin B1-treated rats

Abdel-Wahhab, Mosaad A.; El‐Nekeety, Aziza A.; Hathout, Amal S.; Salman, Asmaa S.; Abdel-Aziem, Sekena H.; Sabry, Bassem A.; Hassan, Nabila S.; Abdel-Aziz, Mohammed S.; Aly, Soher E.; Jaswir, Irwandi

doi:10.1016/j.toxicon.2020.04.103

Cited by 20 publications

(11 citation statements)

References 84 publications

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“…Mouldy bread induced genotoxicity in the present study in consistence with previous reports [22,40] stating that AFB1 significantly increased chromosomal aberrations and DNA fragmentation in rats. AFBO formation leads to the formation of covalent N guanine-adducts [41] .…”

Section: Discussionsupporting

confidence: 92%

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The Ameliorative Effect of Turmeric Against Aflatoxin Toxicity in Male Albino Rats Fed on Mouldy

Mahmoud

Helaly

El-Dash

2022

Egyptian Journal of Zoology

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Moulds are found in many foodstuffs and produce toxic substances known as mycotoxins which are dangerous to the human health and livestock. Aflatoxins (AFs) are the most important mycotoxins affecting the human health and trade in the world. There is an inevitable exposure to AFs in developing countries. The current study aimed to investigate the ameliorative role of turmeric (tur) against AFs toxicity in adult male albino rats (Rattus norvegicus) fed on mouldy bread. Twenty-four rats were equally allotted into 4 groups: GpI (control group: fed on dry normal bread), GpII (mouldy bread group: fed on mouldy bread), GpIII (fed on normal bread + 60 mg tur/kg body weight/day), and GpIV (fed on mouldy bread + 60 mg tur/kg body weight/day). Total AFs concentration was measured in mouldy bread, and accordingly the daily dose of AFs was 0.272 mg/kg body weight of rat. After 30 days, the effect of tur on AFs toxicity was evaluated by investigating the activity of aminotransferases, kidney function, lipid profile, and glucose level in serum, as well as genotoxicity and histopathological alterations. Feeding rats with mouldy bread containing AFs led to a significant increase in the activities of serum aspartate and alanine aminotransferases, the concentrations of serum creatinine, urea, total cholesterol, triacylglycerol, low-density lipoprotein cholesterol, and glucose, as well as genotoxicity in bone marrow cells and histopathological lesions in the liver and kidneys tissues. However, tur supplementation alleviated significantly almost all the above-mentioned harmful effects of AFs.

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Section: Discussionsupporting

confidence: 92%

“…AFs contaminated bread induced genotoxicity and histopathological lesions that were observed in the liver and kidney, as shown in the current and previous studies [22][23][24][25][26] . The liver is the most affected organ by AFB1 [9] .…”

Section: Discussionsupporting

confidence: 82%

The Ameliorative Effect of Turmeric Against Aflatoxin Toxicity in Male Albino Rats Fed on Mouldy

Mahmoud

Helaly

El-Dash

2022

Egyptian Journal of Zoology

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“…P53 is involved in the cell cycle regulation, DNA repair, and apoptosis. The P53 can boost apoptosis through specific pro‐ and anti‐apoptotic genes downregulation [78,79]. Previous research suggests that P53's pro‐apoptotic action is unrelated to its role as a transcription factor.…”

Section: Resultsmentioning

confidence: 99%

The synthesis and antineoplastic activities of thiaziridine, sulfidometylphosphonium, and dithiaphosphitane‐sulfide against the Ehrlich ascites carcinoma

Mansour

Hashem

Abd‐El‐Maksoud

et al. 2022

Fundamemntal Clinical Pharma

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Phosphonium compounds offer an attractive branch of research that chemists and biologists apply for producing many novel drugs for various applications, and its polymeric ingredients are composed of quaternary ammonium and phosphonium salts. The reactions of isothiocyanate with phosphinimine bestow thiaziridine, carbamate, and thiourea derivatives. Moreover, isothiocyanate reacts with tris (dimethylamino) phosphine leading to the formation of sulfidomethyl phosphonium. Lawesson's and Japanese reagents have potential to react with isothiocyanates to generate dithiaphosphetane sulfides. Treatment of isocyanate with Lawesson's or Japanese reagents under reflux conditions affords thiaphosphetidinone sulfide, but when applied at room temperature, the dithiaphosphetane sulfide was isolated. Ehrlich ascites carcinoma (EAC) mice model was used to investigate potential anticancer properties of the novel phosphonium and thiophosphate derivatives. Synthesized compounds (100 mg/kg b.w.) were administered orally to the EAC‐bearing mice for about 2 weeks. Compounds' antineoplastic activity was determined by the evaluation of volume, viability, and inhibition percent of EAC cells. In addition, DNA fragmentation percent was assessed. The expression of apoptotic marker genes (Bax, Bcl2, Caspase 3) and encoding proinflammatory cytokines (TNF‐α) and pro‐apoptotic protein (p53) were inspected by real time‐quantitative polymerase chain reaction (RT‐qPCR). The overall conclusion was based on the findings that treatment with synthesized compounds leads to decrease in tumor volume, increase in tissue DNA fragmentation, downregulation of Bcl2 gene, and upregulation of Bax, caspase3, and p53 markers, along with decrease in TNF‐α level in liver tissues. These findings suggest that the anticancer mechanism of these compounds is based on the programmed cell death (Apoptosis).

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“…Administration of TiO 2 -NPs displayed severe disturbances in the biochemical indices, the oxidant/antioxidant parameters, serum cytokines, gene expression, DNA damage, and the histological construction of the hepatic tissues. The increase of AST and ALT in the TiO 2 -NPs-treated group indicated that these nanoparticles induced injury and damage to the hepatocytes resulting in the release of these enzymes into the circulation [ 48 , 49 ], and the decrease in Alb and TP in this group also confirmed the hepatic damage and/or the kidney dysfunction [ 50 ]. Additionally, the increase in creatinine, uric acid, and urea indicated nephrotoxicity and glomerular injury [ 51 , 52 ].…”

Section: Discussionmentioning

confidence: 99%

Assessment of the Oxidative Damage and Genotoxicity of Titanium Dioxide Nanoparticles and Exploring the Protective Role of Holy Basil Oil Nanoemulsions in Rats

Sallam

Ahmed

El‐Nekeety

et al. 2022

Biol Trace Elem Res

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This study was designed to evaluate the oxidative damage, genotoxicity, and DNA damage in the liver of rats treated with titanium nanoparticles (TiO2-NPs) with an average size of 28.0 nm and ξ-potential of − 33.97 mV, and to estimate the protective role of holy basil essential oil nanoemulsion (HBEON). Six groups of Male Sprague–Dawley rats were treated orally for 3 weeks as follows: the control group, HBEO or HBEON-treated groups (5 mg/kg b.w), TiO2-NPs-treated group (50 mg/kg b.w), and the groups treated with TiO2-NPs plus HBEO or HBEON. Samples of blood and tissues were collected for different analyses. The results revealed that 55 compounds were identified in HBEO, and linalool and methyl chavicol were the major compounds (53.9%, 12.63%, respectively). HBEON were semi-round with the average size and ζ-potential of 120 ± 4.5 nm and − 28 ± 1.3 mV, respectively. TiO2-NP administration increased the serum biochemical indices, oxidative stress markers, serum cytokines, DNA fragmentation, and DNA breakages; decreased the antioxidant enzymes; and induced histological alterations in the liver. Co-administration of TiO2-NPs plus HBEO or HBEON improved all the tested parameters and the liver histology, and HBEON was more effective than HBEO. Therefore, HEBON is a promising candidate able to protect against oxidative damage, disturbances in biochemical markers, gene expression, DNA damage, and histological changes resulting from exposure to TiO2-NPs and may be applicable in the food and pharmaceutical sectors.

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Bioactive compounds from Aspergillus niger extract enhance the antioxidant activity and prevent the genotoxicity in aflatoxin B1-treated rats

Cited by 20 publications

References 84 publications

The Ameliorative Effect of Turmeric Against Aflatoxin Toxicity in Male Albino Rats Fed on Mouldy

The Ameliorative Effect of Turmeric Against Aflatoxin Toxicity in Male Albino Rats Fed on Mouldy

The synthesis and antineoplastic activities of thiaziridine, sulfidometylphosphonium, and dithiaphosphitane‐sulfide against the Ehrlich ascites carcinoma

Assessment of the Oxidative Damage and Genotoxicity of Titanium Dioxide Nanoparticles and Exploring the Protective Role of Holy Basil Oil Nanoemulsions in Rats

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