Bioactive compounds from marine <i>Streptomyces</i> sp.: Structure identification and biological activities

Abd-Ellatif, Aya E. S.; Hamed, Abdelaaty; Soltan, Maha M.; Soliman, Hesham S. M.; Shaaban, Mohamed

doi:10.1002/vjch.201900108

Cited by 10 publications

(5 citation statements)

References 35 publications

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“…The soft coral-derived fungus Penicillium has a variety of active metabolites, and Boulis et al identified its chemical structure by fingerprinting, and found that the active metabolite has high antibacterial, anti-yeast, and cytotoxic activities [ 7 ]. Abd-Ellatif et al carried out the structural identification of biologically active compounds of marine Streptomyces by spectrometry and chromatography, and tested their biological activities [ 8 ]. Ma et al optimized the extraction process of diterpenoids from Euphorbia.…”

Section: Introductionmentioning

confidence: 99%

[Retracted] Endophytic Fungi and Secondary Metabolites of Rehmannia Glutinosa Based on Traditional Chinese Medicine Fingerprints

Geng

2022

Contrast Media & Molecular Imaging

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Research on the active components of medicinal plants has always been the focus of research, and research on the active components of medicinal plant endophytic fungi and their secondary metabolites has also attracted widespread attention. Endophytic fungi of medicinal plants are widely distributed and are ubiquitous in various biological groups in nature. Rehmannia glutinosa contains a variety of active ingredients, which are regarded as the top grade of Chinese medicinal materials. It is of certain significance to study endophytic fungi and their metabolites of Rehmannia glutinosa. In this paper, endophytic fungi and their secondary metabolites of Rehmannia glutinosa were studied using fingerprint technology, which initially understands the diversity of endophytic fungi in Rehmannia glutinosa. In this paper, the roots and leaves of Rehmannia glutinosa were used as experimental materials. The fungi were cultured in the medium, the fungi were isolated and purified by the tissue block method, the fungal growth of Rehmannia glutinosa in different parts was determined, and the types of endophytic fungi were identified by microscopic identification and fingerprinting. The isolated strains were tested for biological activity using oryza oryzae spores, and highly active strains were screened. Fermentation products of endophytic fungi were separated and purified by chromatography, and the structure of the compounds was identified by nuclear magnetic resonance spectroscopy. Through the above studies, the population structure of endophytic fungi of Rehmannia glutinosa was determined, 3 highly active strains were found, and the structures of 7 endophytic fungi metabolites were identified, of which 3 were newly discovered compounds.

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Section: Introductionmentioning

confidence: 99%

[Retracted] Endophytic Fungi and Secondary Metabolites of Rehmannia Glutinosa Based on Traditional Chinese Medicine Fingerprints

Geng

2022

Contrast Media & Molecular Imaging

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“…Me myristate was promised to be exploited as a hydrophobic medical carrier [ 58 ]. Me linoleate exhibited cytotoxic antibacterial activities against Bacillus subtilis and Staphylococcus aureus [ 59 , 60 ]. Modern medicine often makes acute respiratory distress syndrome models by injecting oleic acid into rabbits or rats [ 61 ].…”

Section: Other Compoundsmentioning

confidence: 99%

Secondary Metabolites of Purpureocillium lilacinum

Chen

2021

Molecules

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Fungi can synthesize a wealth of secondary metabolites, which are widely used in the exploration of lead compounds of pharmaceutical or agricultural importance. Beauveria, Metarhizium, and Cordyceps are the most extensively studied fungi in which a large number of biologically active metabolites have been identified. However, relatively little attention has been paid to Purpureocillium lilacinum. P. lilacinum are soil-habituated fungi that are widely distributed in nature and are very important biocontrol fungi in agriculture, providing good biological control of plant parasitic nematodes and having a significant effect on Aphidoidea, Tetranychus cinnbarinus, and Aleyrodidae. At the same time, it produces secondary metabolites with various biological activities such as anticancer, antimicrobial, and insecticidal. This review attempts to provide a comprehensive overview of the secondary metabolites of P. lilacinum, with emphasis on the chemical diversity and biological activity of these secondary metabolites and the biosynthetic pathways, and gives new insight into the secondary metabolites of medical and entomogenous fungi, which is expected to provide a reference for the development of medicine and agrochemicals in the future.

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“…The genus Streptomyces accounts for a major fraction of all natural products recovered from actinomycetes to date [3]. Streptomyces were recovered from diverse marine sources including sea sediment, sea water and marine invertebrates such as soft corals, tunicates and sponges [4, 5].…”

Section: Full-textmentioning

confidence: 99%

“…Fatty acid composition (%) of strain RV15 T and the type strains of its closest related species Strains: 1, RV15 T ; 2, Streptomyces caeruleatus GIMN 4.002 T ; 3, Streptomyces shaanxiensis CCNWQ 0031 T ; 4, Streptomyces curacoi JCM 4219 T ; 5, Streptomyces lincolnensis NBRC 13054 T . Data for (2) from Lin et al [38], data for (3) from Zhu et al [9], data for (4) from Klykleong et al [39], data for (5) from Nyugen and Kim [40] obtained exactly under the same conditions. tr, traces; -, not detected.…”

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confidence: 98%

Streptomyces dysideae sp. nov., isolated from a marine Mediterranean sponge Dysidea tupha

Glaeser

Rückert

Abdelmohsen

et al. 2019

International Journal of Systematic and Evolutionary Microbiology

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A Gram-stain-positive bacterium, strain RV15T, forming an extensively branched substrate mycelium and aerial hyphae that differentiate into spiral chains of spores, was isolated from a marine sponge Dysidea tupha collected from Rovinj (Croatia). Comparison of 16S rRNA gene sequences showed that strain RV15T is a member of the genus Streptomyces with highest sequence similarity to the type strains of Streptomyces caeruleatus (98.8 %), Streptomyces cyaneochromogenes (98.6 %) and Streptomyces shaanxiensis (98.5 %). Sequence similarities to all other Streptomyces types strains were below 98.5 %. The multilocus sequence analysis-based evolutionary distance, the average nucleotide identity value and the genome-to-genome distance of strain RV15T and the type strain of S. caeruleatus were clearly below the species cut-off values. Strain RV15T exhibited a quinone system composed of the major menaquinones MK-9(H4), MK-9(H6) and MK-9(H2), typical for the genus Streptomyces . The polar lipid profile of strain RV15T consisted of the predominant compounds diphosphatidylglycerol and phosphatidylethanolamine, moderate amounts of phosphatidylinositol, phosphatidylinositol mannoside, an unidentified lipid and an unidentified phospholipid. Major polyamines were spermine and spermidine. The diagnostic diaminoacid of the peptidoglycan was meso-diaminopimelic acid. The major fatty acids were iso C16 : 0, anteiso C17 : 1 ω9c and anteiso C17 : 0. The results of physiological and biochemical tests allowed further phenotypic differentiation of strain RV15T from its most-related species and hence clearly merits species status. We propose the name Streptomyces dysideae sp. nov. with the type strain RV15T (=DSM 42110T=LMG 27702T).

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Bioactive compounds from marine Streptomyces sp.: Structure identification and biological activities

Cited by 10 publications

References 35 publications

[Retracted] Endophytic Fungi and Secondary Metabolites of Rehmannia Glutinosa Based on Traditional Chinese Medicine Fingerprints

[Retracted] Endophytic Fungi and Secondary Metabolites of Rehmannia Glutinosa Based on Traditional Chinese Medicine Fingerprints

Secondary Metabolites of Purpureocillium lilacinum

Streptomyces dysideae sp. nov., isolated from a marine Mediterranean sponge Dysidea tupha

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