Bioactive Compounds from Medicinal Plants in Myanmar

Win, Nwet Nwet; Morita, Hiroyuki

doi:10.1007/978-3-030-59444-2_2

Cited by 3 publications

(2 citation statements)

References 445 publications

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“…In addition to antidiabetic activity, alkaloids were shown to play a great role in the management of neurodegenerative disorders [77], inflammatory bowel diseases [78], viral diseases [79,80], microbial infections [22,81], cancers [82], and many more. In recent years, many research studies have been carried out in medicinal plants to explore bioactive compounds [83][84][85][86][87][88][89][90][91].…”

Section: Inhibition Of Advanced Glycation End Productsmentioning

confidence: 99%

Roles of Alkaloids from Medicinal Plants in the Management of Diabetes Mellitus

Adhikari

2021

Journal of Chemistry

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Medicinal plants play a fundamental part in health sectors via the management of different infectious diseases because of their wide plenitude wellspring of bioactive phytochemicals. Research activities on them have got attention throughout the world in the present days in search of low-cost and safe compounds for the management of diabetes. This is the literature-based analysis of alkaloids from medicinal plants in preventive or treatment approaches to diabetes. The most abundant and diversified group of secondary metabolites, i.e., alkaloids, show antidiabetic activity through the inhibition of enzymes (α-amylase, α-glucosidase, aldose reductase, dipeptidyl peptidase-IV, and protein tyrosine phosphatase-1B); inhibition of advanced glycation end products; increment of insulin secretion and its sensitivity; enhancement of glucose uptake; and their antioxidant ability. The study is useful for the examination of dynamic alkaloids for the advancement of a new medication for mankind.

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Section: Inhibition Of Advanced Glycation End Productsmentioning

confidence: 99%

Roles of Alkaloids from Medicinal Plants in the Management of Diabetes Mellitus

Adhikari

2021

Journal of Chemistry

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“…These factors highlight the continued interest in the use of herbal medicines as a viable alternative or complementary approach in healthcare. Medicinal plants are known to contain substances that aid primarily in the reproduction, growth, disease prevention, health promotion and efficient functioning of living organisms [5,6]. Elemental analysis has revealed that many plant families contain substantial amounts of macro-and microelements as well as phytochemicals.…”

Section: Introductionmentioning

confidence: 99%

Microbial content and elemental analysis of some locally prepared herbal remedies (<i>Agbo</i>) in Ibadan metropolis

Ogbole,

Ajayi,

Ajala

et al. 2023

J. Pharm Bio.

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This study assessed the safety of two herbal remedies, Agbo Iba and Agbo Jedi commonly sold in Ibadan metropolis. The samples were analyzed for phytochemical composition, microbial contamination, pH level, and elemental content. Phytochemical screening identified alkaloids, cardiac glycosides, saponins, steroids, tannins and glycosides. Elemental analysis revealed sodium concentration ranging from 186.67 ± 1.7 to 283.33 ± 4.41 mg/100 g in Agbo Iba and Agbo Jedi, respectively. Lead content ranged from 0.04 ± 0.01 to 0.10 ± 0.00 mg/100 g in Agbo Iba and 0.03 ± 0.00 to 0.05 ± 0.00 mg/100 g in Agbo Jedi, while cadmium content ranged from 0.01 ± 0.00 to 0.02 ± 0.00 mg/100 g in Agbo Iba, it was absent in Agbo Jedi. The pH of all samples was acidic ranging from 2.79 to 4.41. Bacterial counts in Agbo Iba and Agbo Jedi exceeded European pharmacopoeia contamination limits ranging from 2 × 108 to 88 × 108 cfu/mL and 2 × 108 to 126 × 108 cfu/mL respectively. These findings highlight potential health hazards associated with these herbal remedies despite their rich phytochemical content. Stringent quality assurance and standardization by government agencies are essential to ensure safety and efficacy of herbal remedies for public use.

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Investigation of HIV‐1 Viral Protein R Inhibitory Activities of Twelve Thai Medicinal Plants and Their Commercially Available Major Constituents

Jaisi

Prema

Madla

et al. 2021

Chemistry & Biodiversity

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Viral protein R (Vpr) is an accessory protein in Human immunodeficiency virus-1 (HIV-1) and has been suggested as an attractive target for HIV disease treatment. Investigations of the ethanolic extracts of twelve Thai herbs revealed that the extracts of the Punica granatum fruits, the Centella asiatica aerials, the Citrus hystrix fruit peels, the Caesalpinia sappan heartwoods, the Piper betel leaves, the Alpinia galangal rhizomes, the Senna tora seeds, the Zingiber cassumunar rhizomes, the Rhinacanthus nasutus leaves, and the Plumbago indica roots exhibited the anti-Vpr activity in HeLa cells harboring the TREx plasmid encoding full-length Vpr (TREx-HeLa-Vpr cells). Moreover, the investigation of the selected main constituents in Punica granatum, Centella asiatica, A. galangal, and Caesalpinia sappan indicated that punicalagin, asiaticoside, ellagic acid, madecassic acid, madecassoside, zingerone, brazilin, and asiatic acid possessed anti-Vpr activities at the 10 μM concentration. Among the tested extracts and compounds, the extracts from Centella asiatica and Citrus hystrix and the compounds, punicalagin and asiaticoside, showed the most potent anti-Vpr activities without any cytotoxicity, respectively.

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Bioactive Compounds from Medicinal Plants in Myanmar

Cited by 3 publications

References 445 publications

Roles of Alkaloids from Medicinal Plants in the Management of Diabetes Mellitus

Roles of Alkaloids from Medicinal Plants in the Management of Diabetes Mellitus

Microbial content and elemental analysis of some locally prepared herbal remedies (<i>Agbo</i>) in Ibadan metropolis

Investigation of HIV‐1 Viral Protein R Inhibitory Activities of Twelve Thai Medicinal Plants and Their Commercially Available Major Constituents

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