Bioactive compounds from Prosthechea karwinskii decrease obesity, insulin resistance, pro-inflammatory status, and cardiovascular risk in Wistar rats with metabolic syndrome

Barragán-Zarate, Gabriela Soledad; Alexander‐Aguilera, Alfonso; Lagunez-Rivera, Luicita; Solano, Rodolfo; Soto-Rodríguez, Ida

doi:10.1016/j.jep.2021.114376

Cited by 7 publications

(2 citation statements)

References 46 publications

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“…According to related literatures [38][39][40][41], chlorogenic acid, isochlorogenic acid A, isochlorogenic acid C, phillyrin, forsythoside A, arctiin, liquiritin, neochlorogenic acid, cynaroside, rutin, and hesperidin can be absorbed into blood in the form of prototype. It has been reported that phillyrin and forsythoside A have good antiviral and immune regulation efects [42][43][44], neochlorogenic acid, isochlorogenic acid A, and isochlorogenic acid C have antiviral and anti-infammatory activities [45,46], while cynaroside has the efect of inhibiting infuenza virus [47]. Liquiritin, hesperidin, and rutin have obvious anti-infammatory efects [48][49][50].…”

Section: Analysis Of Blood Components In Yinqiao Powdermentioning

confidence: 99%

Establishment of Quality Evaluation Method for Yinqiao Powder: A Herbal Formula against COVID-19 in China

Zhang

Jian

et al. 2022

Journal of Analytical Methods in Chemistry

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Yinqiao powder, with significant anti‐inflammatory and antiviral effects, is a classical formula for the treatment of febrile diseases in China. During the SARS period in 2003, Yinqiao powder showed a good antipyretic effect. It also plays a major role in the treatment for COVID-19 in China. Although there are many studies on the chemical compositions and pharmacological effects of Yinqiao powder, there are few studies on the quality standard system of it. In our study, a systematic quality evaluation method of Yinqiao powder combining HPLC fingerprint with quantitative analysis of multi-components by single marker (QAMS) based on network pharmacology and UPLC-Q-Exactive-Orbitrap-MS was established for the first time. In the UPLC-Q-Exactive-Orbitrap-MS experiment, a total of 53 compounds were identified in the extract solution of Yinqiao powder. In addition, 33 blood components were characterized, 23 of which were prototypes. The results of network pharmacology analysis showed that Yinqiao powder may inhibit inflammatory responses by suppressing IL-6, CXCL2, TNFα, NF-κB, etc., in the treatment of COVID-19. The HPLC fingerprint analysis of Yinqiao powder was conducted at 237 nm and 29 characteristic peaks were matched, 11 of which were identified. Forsythoside A was selected as the internal standard reference and double-wavelength (237 nm and 327 nm) was established in QAMS experiment. The repeatability was well under different conditions, and the results measured by QAMS were consisted with that of the external standard method (ESM), indicating that the QAMS method was reliable and accurate. The quality evaluation method of Yinqiao powder would be helpful to evaluate the intrinsic quality of Yinqiao powder more comprehensively, which is conducive to improve the quality standard of Yinqiao powder and provide a beneficial guarantee for the clinical treatment of COVID-19.

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Section: Analysis Of Blood Components In Yinqiao Powdermentioning

confidence: 99%

Establishment of Quality Evaluation Method for Yinqiao Powder: A Herbal Formula against COVID-19 in China

Zhang

Jian

et al. 2022

Journal of Analytical Methods in Chemistry

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show abstract

“…This requests the usage of several drugs to effectively target all associated dysfunctions. Multitherapy medicine however, exposes patients to a large number of adverse effects [ [14] , [15] , [16] ]. Thus, it is essential to develop more effective and less expensive alternative therapies for better management of the CMS.…”

Section: Introductionmentioning

confidence: 99%

The methanol extract of Ceiba pentandra reverses monosodium glutamate-induced cardiometabolic syndrome in rats via the regulation of dyslipidemia, inflammation, oxidative stress, and insulin sensitization

Wuyt¹,

Nguelefack‐Mbuyo²,

Fofié³

et al. 2023

Heliyon

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Validation of the traditional medicinal use of a Mexican endemic orchid (Prosthechea karwinskii) through UPLC-ESI-qTOF-MS/MS characterization of its bioactive compounds

Barragán-Zarate

Lagunez-Rivera²,

Solano³

et al. 2022

Heliyon

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Bioactive compounds from Prosthechea karwinskii decrease obesity, insulin resistance, pro-inflammatory status, and cardiovascular risk in Wistar rats with metabolic syndrome

Cited by 7 publications

References 46 publications

Establishment of Quality Evaluation Method for Yinqiao Powder: A Herbal Formula against COVID-19 in China

Establishment of Quality Evaluation Method for Yinqiao Powder: A Herbal Formula against COVID-19 in China

The methanol extract of Ceiba pentandra reverses monosodium glutamate-induced cardiometabolic syndrome in rats via the regulation of dyslipidemia, inflammation, oxidative stress, and insulin sensitization

Validation of the traditional medicinal use of a Mexican endemic orchid (Prosthechea karwinskii) through UPLC-ESI-qTOF-MS/MS characterization of its bioactive compounds

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