Bioactive compounds from the seeds of <i>Amomum tsaoko</i> Crevost et Lemaire, a Chinese spice as inhibitors of sphingosine kinases, SPHK1/2

Lee, Seulah; Lee, Joo Chan; Subedi, Lalita; Cho, Kyo Hee; Kim, Sun Yeou; Park, Hyun-Ju; Kim, Ki‐Hyun

doi:10.1039/c9ra07988b

Cited by 16 publications

(20 citation statements)

References 58 publications

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“…Schischk. Apiaceae root Hamaduol, Ledebouriellol, Divaricatol, Cimifugin, Anomalin, Scopoletin, Marmesin, Isofraxidin, Fraxidin, Divaricoumarin A-B-C, Kreiner et al (2017) Scutellaria baicalensis Baikal skullcap or Chinese skullcap Lamiaceae Dried root Baicalein, Wogonin, neobaicalein, and skullcapflavone Bonham et al (2005) Lanxangia tsaoko (Syn: Amomum tsao-ko) cao guo Zingiberaceae Ripe fruit and leaves cineole Lee et al (2019) …”

Section: Medicinal Plants For Viral Respiratory Infections (Vri)mentioning

confidence: 99%

Therapeutic potential of medicinal plants against COVID-19: The role of antiviral medicinal metabolites

Khan

Mashwani

et al. 2021

Biocatalysis and Agricultural Biotechnology

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Section: Medicinal Plants For Viral Respiratory Infections (Vri)mentioning

confidence: 99%

Therapeutic potential of medicinal plants against COVID-19: The role of antiviral medicinal metabolites

Khan

Mashwani

et al. 2021

Biocatalysis and Agricultural Biotechnology

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“…For a long time in history, it has been used for the interior obstruction of cold-dampness and distending pain in the epigastrium and abdomen, stuffiness and fullness, vomiting, malaria with cold and fever, and pestilence fever [5]. In recent years, A. tsaoko have been proved having anti-inflammatory effect against insects, antitumor effect in liver cancer cells, anti-angiogenesis efficacy in ovarian cancer, and inhibited sphingosine kinases 1 and 2 (SPHK1/2) [6,7]. The essential oil is one of the major active products of the black cardamom, mainly consisting of monoterpene hydrocarbons and oxygenated monoterpenes [8].…”

Section: Introductionmentioning

confidence: 99%

Correlation Analysis of Compounds in Essential Oil of Amomum tsaoko Seed and Fruit Morphological Characteristics, Geographical Conditions, Locality of Growth

Wang

et al. 2021

Agronomy

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Amomum tsaoko is a perennial herb belonging to Zingiberaceae. Its dried ripe fruit is an important food additive, spice and materia medicai in Southeast Asia. For hundreds of years of cultivation, morphological variations have existed. The essential oil is one of the major active products of the A. tsaoko fruit and seed. In this study, we collected 12 populations in Yunnan province, and the correlation analysis of compounds was focused on the essential oil of A. tsaoko seed and its fruit morphological characteristics, geographical conditions, and locality of growth. The results showed that the difference in morphological characteristics between populations is greater than the difference within the population. High altitude areas are beneficial for biomass accumulation. Another interesting finding is that selecting specific functional or odor type materials could reference the morphologies of A. tsaoko fruit and seed. Furthermore, the qualitative and quantitative analysis of compounds in essential oil could be used to distinguish the producing area of the A. tsaoko fruit. These results are crucial in realizing the determination of botanical origin and evaluating the quality of A. tsaoko fruit. Meanwhile, it makes clear that various other studies on this plant deserve more attention.

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“…Chemical processing of the extract led to the isolation and identification of various compounds, including phenolics, fatty acids, terpenoids, and aliphatic alcohols. Two compounds exhibited inhibitory action by binding to the substrate-binding pocket of both the isoforms of SphK [ 237 ]. Lee et al [ 174 ] showed the anticancer effects of pristimerin, a triterpenoid quinone methide, that inhibits the HIF-1α accumulation via the inactivation SphK1 signaling cascade in a hypoxic prostate cancer cell line (PC-3).…”

Section: Inhibitors Of Sphkmentioning

confidence: 99%

Targeting the Sphingosine Kinase/Sphingosine-1-Phosphate Signaling Axis in Drug Discovery for Cancer Therapy

Gupta

Taiyab

Hussain

et al. 2021

Cancers

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Sphingolipid metabolites have emerged as critical players in the regulation of various physiological processes. Ceramide and sphingosine induce cell growth arrest and apoptosis, whereas sphingosine-1-phosphate (S1P) promotes cell proliferation and survival. Here, we present an overview of sphingolipid metabolism and the compartmentalization of various sphingolipid metabolites. In addition, the sphingolipid rheostat, a fine metabolic balance between ceramide and S1P, is discussed. Sphingosine kinase (SphK) catalyzes the synthesis of S1P from sphingosine and modulates several cellular processes and is found to be essentially involved in various pathophysiological conditions. The regulation and biological functions of SphK isoforms are discussed. The functions of S1P, along with its receptors, are further highlighted. The up-regulation of SphK is observed in various cancer types and is also linked to radio- and chemoresistance and poor prognosis in cancer patients. Implications of the SphK/S1P signaling axis in human pathologies and its inhibition are discussed in detail. Overall, this review highlights current findings on the SphK/S1P signaling axis from multiple angles, including their functional role, mechanism of activation, involvement in various human malignancies, and inhibitor molecules that may be used in cancer therapy.

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Bioactive compounds from the seeds of Amomum tsaoko Crevost et Lemaire, a Chinese spice as inhibitors of sphingosine kinases, SPHK1/2

Abstract: New bioactive compounds were identified from the seeds of Amomum tsaoko Crevost et Lemaire, a Chinese spice as inhibitors of sphingosine kinases, SPHK1/2.

Cited by 16 publications

References 58 publications

Therapeutic potential of medicinal plants against COVID-19: The role of antiviral medicinal metabolites

Therapeutic potential of medicinal plants against COVID-19: The role of antiviral medicinal metabolites

Correlation Analysis of Compounds in Essential Oil of Amomum tsaoko Seed and Fruit Morphological Characteristics, Geographical Conditions, Locality of Growth

Targeting the Sphingosine Kinase/Sphingosine-1-Phosphate Signaling Axis in Drug Discovery for Cancer Therapy

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