Bioactive Compounds In Pegagan Leaf (Centella asiatica L. Urban) for Wound Healing

Irham, Wardatul Husna; Tamrin,; Marpaung, Lamek; Marpongahtun, .

doi:10.1088/1742-6596/1232/1/012019

Cited by 10 publications

(7 citation statements)

References 8 publications

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“…Added that flavonoids are potential antioxidants as free radical scavengers and fat oxidation inhibitors [43,44,45,46,47,48,49]. The antioxidant content of gotu kola leaves comes from triterpenoids and the main compounds that have strong antioxidant activity are asiaticoside compounds [50,51,52].…”

Section: Antioxidant Activitymentioning

confidence: 99%

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Physicochemical Properties of Herbal Tea Bags from Belimbing Wuluh Leaves (Averrhoa bilimbi) and Gotu Kola Leaves (Centella asiatica) with the Addition of Cinnamon Powder (Cinnamomun burmanii)

Sylvi

Syukri

Rozi

et al. 2022

EKSAKTA

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This study aims to study the characteristics of herbal teabags from belimbing wuluh leaves and gotu kola leaves with the addition of cinnamon powder. This study used a completely randomized design with 5 treatments, namely differences in the addition of cinnamon powder 0%, 1%, 2%, 3% and 4% with 3 replications. The data obtained were analyzed statistically using ANOVA (Analysis Of Variance) and if they were significantly different, then continued with the DNMRT (Duncan's News Multiple Range Test) test at 5% level. The results showed that the level of addition of cinnamon powder had a significant effect on antioxidant activity, total water soluble ingredients, total polyphenols, color, taste, and flavor. Differences in the substitution level of cinnamon powder had no significant effect on water content and pH. The best treatment in this study was treatment E with the addition of 4% cinnamon powder, the organoleptic results obtained were the average value of color preference 3.95 (like), taste 3.65 (like), and flavor 4 (like). The results of chemical analysis on tea products are water content 7.88%, total polyphenols 109.32 mg GAE/g, IC50 value 96.71, total water soluble ingredients 19.66% and in steeped tea pH value is 6.13, and activity antioxidant 36.93%.

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Section: Antioxidant Activitymentioning

confidence: 99%

“…The ability of gotu kola to stimulate memory is thought to be caused by the triterpenoid saponin compounds (asiaticoside) contained in it [10,11]. This compound is known to repair damaged blood vessels so as to facilitate blood circulation to the brain and is able to regenerate cells and heal wounds [12].…”

Section: Introductionmentioning

confidence: 99%

Physicochemical Properties of Herbal Tea Bags from Belimbing Wuluh Leaves (Averrhoa bilimbi) and Gotu Kola Leaves (Centella asiatica) with the Addition of Cinnamon Powder (Cinnamomun burmanii)

Sylvi

Syukri

Rozi

et al. 2022

EKSAKTA

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“…The pharmacological activity of pegagan leaves is related to their secondary metabolites. Pegagan leaves contain flavonoid compounds, saponins, triterpenoids, alkaloids, phenolics, and glycosides (Gray et al, 2018;Irham et al, 2019). Pegagan leaves contain the most triterpenoid compounds such as asiaticoside, madecossida, asiatic acid, and centellosida (Irham et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…Pegagan leaves contain flavonoid compounds, saponins, triterpenoids, alkaloids, phenolics, and glycosides (Gray et al, 2018;Irham et al, 2019). Pegagan leaves contain the most triterpenoid compounds such as asiaticoside, madecossida, asiatic acid, and centellosida (Irham et al, 2019). In addition, pegagan leaves also contain lots of flavonoid compounds such as rutin, quercetin, kaempferol, and luteolin (Azmin and Nor, 2020).…”

Section: Introductionmentioning

confidence: 99%

Development of Nanoparticles Pegagan Leaves Ethanolic Extract (centella asiatica (L.) Urban) using Variation Concentration of Poly-Lactic-CO-Glycolic Acid (PLGA) Polymer

2022

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Pegagan is a plant that plays an important role in health because of its secondary metabolite. However, many secondary metabolites tend to be unstable when exposed to UV light and oxygen such as flavonoid and terpenoid. The purpose of this study was to formulate the ethanolic extract of pegagan leaves into nanoparticle preparations to increase the stability of the extract. Nanoparticle preparations were made using the emulsion solvent evaporation method using Poly-Lactic-Co-Glycolic Acid (PLGA) and polyvinyl alcohol (PVA). PLGA acts as a polymer that will coat the extract and PVA as a stabilizer. Variations in the concentration of PLGA used were 50 mg, 75 mg, and 100 mg, while the concentration of PVA used was 40 mg and the extract concentration was 158 mg. Determination of the best formula is done by looking at the results of the percent encapsulation efficiency obtained from the three formulas, namely 93.68%, 85.35%, and 88.76%, respectively. Based on these results, formula 1 was determined as the best formula. The particle size obtained in the best formula was 288.1667±3.4195 nm, the polydispersity index (PDI) was 0.371±0.0045 and the zeta potential value was -10.6333±0.1154. A physical stability test (cycling test method) of the best formula found a decrease in pH of 0.54 and no organoleptic changes or precipitate formed.

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“…Gotu kola contains asiatic acid and asiaticoside, which have antioxidant and neuroprotective properties. It also has other nutritious compounds, such as centelloside and madecassoside (Irham et al, 2019). Rather et al (2018) have reported that asiatic acid can prevent oxidative stress and Volume 32 Issue 2 (2021) apoptosis in rats with aluminum chloride-induced dementia.…”

Section: Introductionmentioning

confidence: 99%

Effects of Centella asiatica L. On Spatial Memory and Bcl-2 Gene Expression in the Hippocampus of Rats Injected With Trimethyltin

Yuliani

Akbar²,

Rochmafihro³

et al. 2021

Indonesian J Pharm

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Cell death (apoptosis) in the hippocampus is related to impaired memory functions. Gotu kola (Centella asiatica) contains asiatic acid and asiaticoside, which act as antioxidants and improve memory function. This study was intended to determine the effects of gotu kola extracts on Bcl-2 gene expression and spatial memory in rats with impaired memory functions due to trimethyltin (TMT) injection. The rats were subdivided into six groups, each group consisting of 10. The normal group was given sodium carboxymethyl cellulose (CMC-Na); the TMT group was given CMC-Na; the positive group was given 200 mg/kg bw citicoline; the extract groups were given a variation of gotu kola extract at 100 (P100), 200 (P200), and 400 mg/kg bw (P400) doses, respectively. These treatments were conducted for 35 days. TMT was injected intraperitoneally on Day 8 of treatment at a dose of 8 mg/kg bw in all groups except the normal group. On Days 29-35, the Morris water maze (MWM) spatial memory test was conducted. The rats were sacrificed, and their hippocampi were taken for immunohistochemical observation of Bcl-2 gene expression. The results showed TMT injection could lower the spatial memory of rats in the MWM and cause apoptosis of the pyramidal cells of the hippocampus. Gotu kola extract at 100, 200 and 400 mg/kg bw could increase the percentage of time spent (duration) and frequency of rats staying in the target quadrant in the probe trial of the MWM and increase Bcl-2 gene expression in the pyramidal cells of the hippocampus. Overall, the results have confirmed that gotu kola extract has the potential to prevent hippocampal cell death and improve the spatial memory of rats injected by TMT.

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Bioactive Compounds In Pegagan Leaf (Centella asiatica L. Urban) for Wound Healing

Cited by 10 publications

References 8 publications

Physicochemical Properties of Herbal Tea Bags from Belimbing Wuluh Leaves (Averrhoa bilimbi) and Gotu Kola Leaves (Centella asiatica) with the Addition of Cinnamon Powder (Cinnamomun burmanii)

Physicochemical Properties of Herbal Tea Bags from Belimbing Wuluh Leaves (Averrhoa bilimbi) and Gotu Kola Leaves (Centella asiatica) with the Addition of Cinnamon Powder (Cinnamomun burmanii)

Development of Nanoparticles Pegagan Leaves Ethanolic Extract (centella asiatica (L.) Urban) using Variation Concentration of Poly-Lactic-CO-Glycolic Acid (PLGA) Polymer

Effects of Centella asiatica L. On Spatial Memory and Bcl-2 Gene Expression in the Hippocampus of Rats Injected With Trimethyltin

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