Bioactive compounds in tomato (Solanum lycopersicum) variety saladette and their relationship with soil mineral content

Flores, Ismael Ramírez; Vásquez-Murrieta, María Soledad; Franco-Hernández, M.O.; Márquez-Herrera, C.; Ponce‐Mendoza, Alejandro; López-Cortéz, Ma. del Socorro

doi:10.1016/j.foodchem.2020.128608

Cited by 27 publications

(17 citation statements)

References 21 publications

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“…Qu is a plant flavanol, which is commonly found in fruits, vegetables, and beverages, such as grapes [25], oranges [26], strawberries [27], onions [28], tomatoes [29], peppers [30], lettuce [31], radish leaves [32], papaya [33], almonds and pistachios [34], and nuts [35], with a chemical structure shown in Figure 1. Qu has been named as 3,3,4,5,7-pentahydroxyflavone by the International Union of Pure and Applied Chemistry (IUPAC) [36,37].…”

Section: Introductionmentioning

confidence: 99%

Potential Therapeutic Targets of Quercetin, a Plant Flavonol, and Its Role in the Therapy of Various Types of Cancer through the Modulation of Various Cell Signaling Pathways

et al. 2021

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Polyphenolic flavonoids are considered natural, non-toxic chemopreventers, which are most commonly derived from plants, fruits, and vegetables. Most of these polyphenolics exhibit remarkable antioxidant, anti-inflammatory, and anticancer properties. Quercetin (Qu) is a chief representative of these polyphenolic compounds, which exhibits excellent antioxidant and anticancer potential, and has attracted the attention of researchers working in the area of cancer biology. Qu can regulate numerous tumor-related activities, such as oxidative stress, angiogenesis, cell cycle, tumor necrosis factor, proliferation, apoptosis, and metastasis. The anticancer properties of Qu mainly occur through the modulation of vascular endothelial growth factor (VEGF), apoptosis, phosphatidyl inositol-3-kinase (P13K)/Akt (proteinase-kinase B)/mTOR (mammalian target of rapamycin), MAPK (mitogen activated protein kinase)/ERK1/2 (extracellular signal-regulated kinase 1/2), and Wnt/β-catenin signaling pathways. The anticancer potential of Qu is documented in numerous in vivo and in vitro studies, involving several animal models and cell lines. Remarkably, this phytochemical possesses toxic activities against cancerous cells only, with limited toxic effects on normal cells. In this review, we present extensive research investigations aimed to discuss the therapeutic potential of Qu in the management of different types of cancers. The anticancer potential of Qu is specifically discussed by focusing its ability to target specific molecular signaling, such as p53, epidermal growth factor receptor (EGFR), VEGF, signal transducer and activator of transcription (STAT), PI3K/Akt, and nuclear factor kappa B (NF-κB) pathways. The anticancer potential of Qu has gained remarkable interest, but the exact mechanism of its action remains unclear. However, this natural compound has great pharmacological potential; it is now believed to be a complementary—or alternative—medicine for the prevention and treatment of different cancers.

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Section: Introductionmentioning

confidence: 99%

Potential Therapeutic Targets of Quercetin, a Plant Flavonol, and Its Role in the Therapy of Various Types of Cancer through the Modulation of Various Cell Signaling Pathways

et al. 2021

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“…For the determination of AA, three tests were used: ABTS •+ , DPPH • , and FRAP, because each one has different mechanisms of action; these radicals can be neutralized by direct reduction (electronic transfer) or radical extinction (transfer of hydrogen atoms) [36]. The results showed that RDI had only minimal effects on the AA values, although some positive effects were observed for DPPH • (week 4) with 1.2 and 2.1 mmol Trolox kg −1 for control and RDI treatments, and for FRAP method (week 1) with 1.1 and 1.3 mmol Trolox kg −1 for control and RDI treatments (Table 4).…”

Section: Deficit Irrigation Effect On Antioxidant Activity (Aa) Total Phenolic Content (Tpc) Lycopene and β-Carotenementioning

confidence: 99%

Scheduling Regulated Deficit Irrigation with Leaf Water Potential of Cherry Tomato in Greenhouse and its Effect on Fruit Quality

et al. 2021

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The tomato cultivated surface is one of the most important surfaces in the world. This crop needs a sufficient and continuous supply of water during vegetative growth. Therefore, production may be at risk in warm and water-scarce areas. Therefore, the implementation of irrigation alternatives such as regulated deficit irrigation (RDI) is of great importance to reduce the use of water and improve the production of the quality of tomatoes. The objective of this work was to evaluate the deficit irrigation scheduling using plant water status as a tool in deficit irrigation. Experimental design was a randomized design with four replications per treatment. Two irrigation treatments were applied: Control (125% of crop evapotranspiration (ETc)) and Regulated Deficit Irrigation (RDI). This latter treatment considered different threshold values of midday leaf water depending on crop phenological stage. No differences were observed in yield, with RDI treatment being more efficient in the use of irrigation water than the control. Besides, RDI tomatoes presented, in general, greater weight, size, Total soluble solids (TSS), sugars, antioxidant activity, lycopene, β-Carotene, and redder color with more intense tomatoes flavor. Finally, it might be said that RDI strategy helped to reduce 53% of irrigation water and to improve the nutritional, functional, and sensory quality of tomatoes.

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“…Quercetin (Que) is widely found in vegetables and fruits, and Que is also found in several herbal medicines. The therapeutic potential of Que has been widely studied because of its ability to inhibit low-density lipoprotein (LDL) oxidation, reduce adhesion molecules and other inflammatory markers, prevent neuronal oxidation and inflammatory damage, and platelet anti-aggregation 6 , 7 . Que has been reported to show significant therapeutic effects in animal models of heart failure, arrhythmias and hypertension in various cardiovascular diseases 8 – 11 .…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of Quercetin against atrial fibrillation explored by network pharmacology combined with molecular docking and experimental validation

Tan

Wei

et al. 2022

Sci Rep

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Atrial fibrillation (AF) is a common atrial arrhythmia for which there is no specific therapeutic drug. Quercetin (Que) has been used to treat cardiovascular diseases such as arrhythmias. In this study, we explored the mechanism of action of Que in AF using network pharmacology and molecular docking. The chemical structure of Que was obtained from Pubchem. TCMSP, Swiss Target Prediction, Drugbank, STITCH, Pharmmapper, CTD, GeneCards, DISGENET and TTD were used to obtain drug component targets and AF-related genes, and extract AF and normal tissue by GEO database differentially expressed genes by GEO database. The top targets were IL6, VEGFA, JUN, MMP9 and EGFR, and Que for AF treatment might involve the role of AGE-RAGE signaling pathway in diabetic complications, MAPK signaling pathway and IL-17 signaling pathway. Molecular docking showed that Que binds strongly to key targets and is differentially expressed in AF. In vivo results showed that Que significantly reduced the duration of AF fibrillation and improved atrial remodeling, reduced p-MAPK protein expression, and inhibited the progression of AF. Combining network pharmacology and molecular docking approaches with in vivo studies advance our understanding of the intensive mechanisms of Quercetin, and provide the targeted basis for clinical Atrial fibrillation treatment.

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Bioactive compounds in tomato (Solanum lycopersicum) variety saladette and their relationship with soil mineral content

Cited by 27 publications

References 21 publications

Potential Therapeutic Targets of Quercetin, a Plant Flavonol, and Its Role in the Therapy of Various Types of Cancer through the Modulation of Various Cell Signaling Pathways

Potential Therapeutic Targets of Quercetin, a Plant Flavonol, and Its Role in the Therapy of Various Types of Cancer through the Modulation of Various Cell Signaling Pathways

Scheduling Regulated Deficit Irrigation with Leaf Water Potential of Cherry Tomato in Greenhouse and its Effect on Fruit Quality

Mechanisms of Quercetin against atrial fibrillation explored by network pharmacology combined with molecular docking and experimental validation

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