Bioactive extracts fromSenecio samnitumHuet

Abstract

The antimicrobial and cytotoxic activities of extracts from Senecio samnitum Huet are reported. Extracts from S. samnitum were able to inhibit the in vitro proliferation of four human tumor cell lines. The dichloromethane extract demonstrated effective cytotoxic activity with IC50 of 22.89 microg mL(-1) on the Caco-2 cell line and the EtOAc extract had IC50 value of 11.91 microg mL(-1) against the COR-L23 cell line. The n-hexane extract displayed the best antibacterial activity against Gram positive bacteria, particularly Staphylococcus aureus. The antifungal activity of all extracts was also seen, particularly against the dermatophytes Trichophyton tonsurans and Microsporum gypseum for the methanol and n-hexane extracts.

Antimicrobial and antioxidant activities ofSeneciospecies growing in the Black Sea region, Turkey

“…Also, it was reported that the compounds isolated from S. cannabifolius showed antibacterial activities against S. aureus and B. subtilis but not E. coli (Wu et al, 2006). Loizzo et al (2006) indicated that the n-hexane extract of S. samnitum displayed the best antibacterial activity against Gram + bacteria, particularly S. aureus, and the different solvent extracts of this species had antifungal activities, particularly against the dermatophytes Trichophyton tonsurans and Microsporum gypseum for the methanol and n-hexane extracts. Same researchers have shown that the methanol extract of S. vulgaris exhibited antimicrobial activity against the Gram + bacteria while S. inaequidens had no antimicrobial activity against tested microorganisms and extracts of both Senecio species had no antimicrobial activities against Gram -bacteria and had weak activities against fungi (Loizzo et al, 2004).…”

“…There are many reports about antioxidant and antimicrobial properties of plants (Sagdic, 2003;Sagdic et al, 2006). Recent studies indicated that several species of Senecio exhibit antimicrobial, antifungal and cytotoxic activities (Barbetti et al, 1986;Pérez et al, 1999;Kiprono et al, 2000;El-Shazly et al, 2002;Garcia et al, 2003;Loizzo et al, 2004Loizzo et al, , 2006.…”

Nitric oxide production, inhibitory, antioxidant and antimycobacterial activities of the fruits extract and flavonoid content of Schinus terebinthifolius

“…Apigenin, a flavone widely distributed in the plant kingdom, displays a variety of pharmacological activities, including the reduction of atopic dermatitis (Yano et al, 2009), hypotension (Loizzo et al, 2006) and anti-inflammatory properties, acting in the inhibition of inflammatory mediators such as NO and prostaglandin E2; iNOS and cyclooxygenase (COX) were also significantly inhibited in vitro using two different murine macrophages (RAW 264.7 and J774 A.1) induced by LPS, which suggests the apigenin mechanism of action (Raso et al, 2001).…”

A comparative study on phenolic components and biological activity of some Senecio species in Turkey

“…Senecio vulagaris played a certain role as emmenagogue and in case of functional amenorrhoea in Europe [16]. Antibacterial and antifungal activity of compounds and extracts from Senecio species have been investigated by many researchers [10,11,14,15,17–19]. But, there are only three studies on antibacterial activity of Senecio species belonging to Turkish flora in the literature [12,20,21].…”