Bioactive flavonoids from Knema elegans

Zhang, You-Xi; Zhao, Lei; Wu, Wen-Chao; Chen, Ye‐Gao; Zhan, Rui

doi:10.1016/j.phytol.2020.12.005

Cited by 7 publications

(7 citation statements)

References 25 publications

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“…The report also found that (2) , naringenin (7) , and dihydrokaempferol (11) were only active in the DPPH model, while (1) and (13) were active in the ABTS model. [ 36 ]…”

Section: Chemical Constituents and Pharmacological Studiesmentioning

confidence: 99%

Flavonoids and other constituents of plants from the genus Knema (Myristicaceae) and their pharmacological studies: An updated review

Salihu,

Salleh

2023

Vietnam Journal of Chemistry

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Flavonoids are a diverse group of natural compounds extensively studied in various research articles. They are widely distributed in the plant kingdom and exhibit various biological activities, including antioxidant, anti‐inflammatory, anticancer, antiviral, and antimicrobial effects. The genus Knema Lour., which contains many species in Southeast Asia, has been traditionally used to treat various ailments. The current review aims to provide a comprehensive update on the isolation of flavonoids and other secondary metabolites from the genus Knema Lour. between 1978 and 2022. It also discusses the pharmacological studies on these phytochemicals, including their effects on nematodes, bacteria, cytotoxicity, inflammation, and acetylcholinesterase. Through these years, 50 flavonoids have been reported from various species of Knema demonstrating promising pharmacological activities. The information presented in this review can provide a scientific foundation for future research on the possible therapeutic applications of Knema species. It also links the plants’ observed biological effects and traditional uses to their chemical characterization. The data was retrieved from various digital databases, including ScienceDirect, Web of Science, Scopus, Wiley, Taylor and Francis, PubMed, Springer, and Google Scholar.

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“…The report also found that (2) , naringenin (7) , and dihydrokaempferol (11) were only active in the DPPH model, while (1) and (13) were active in the ABTS model. [ 36 ]…”

Section: Chemical Constituents and Pharmacological Studiesmentioning

confidence: 99%

Flavonoids and other constituents of plants from the genus Knema (Myristicaceae) and their pharmacological studies: An updated review

Salihu,

Salleh

2023

Vietnam Journal of Chemistry

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show abstract

“…[2] Previous chemical investigations revealed the presence of phenol lipid derivatives, lignans, stilbenes and flavonoids from Knema plants. [1,[3][4][5][6] Knema plant extracts and its active compounds showed many pharmacological effects such as anticancer, antidiabetic, anti-inflammatory, and acetylcholinesterase inhibitory activities. [1,[3][4][5][6] Knema pachycarpa de Wilde "Mau cho trai day" is a native tree in Vietnam and only few chemical studies of this Knema species have been reported.…”

Section: Introductionmentioning

confidence: 99%

“…[1,[3][4][5][6] Knema plant extracts and its active compounds showed many pharmacological effects such as anticancer, antidiabetic, anti-inflammatory, and acetylcholinesterase inhibitory activities. [1,[3][4][5][6] Knema pachycarpa de Wilde "Mau cho trai day" is a native tree in Vietnam and only few chemical studies of this Knema species have been reported. In the continuation of our study on Knema species, [7][8][9][10] the chemical constituents of Knema pachycarpa leaves were investigated.…”

Section: Introductionmentioning

confidence: 99%

“…[ 2 ] Previous chemical investigations revealed the presence of phenol lipid derivatives, lignans, stilbenes and flavonoids from Knema plants. [ 1,3‐6 ] Knema plant extracts and its active compounds showed many pharmacological effects such as anticancer, antidiabetic, anti‐inflammatory, and acetylcholinesterase inhibitory activities. [ 1,3‐6 ]…”

Section: Introductionmentioning

confidence: 99%

“…[ 1,3‐6 ] Knema plant extracts and its active compounds showed many pharmacological effects such as anticancer, antidiabetic, anti‐inflammatory, and acetylcholinesterase inhibitory activities. [ 1,3‐6 ]…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Secondary metabolites from leaves of Knema pachycarpa possessing cytotoxic and acetylcholinesterase inhibitory activities

Thanh,

Giap,

Oanh

et al. 2023

Vietnam Journal of Chemistry

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Phytochemical study of Knema pachycarpa leaves led to the isolation of ten compounds. Their chemical structures were determined as (7”R, 8”R)‐hydnocarpin D (1), (7”R, 8”R)‐hydnocarpin (2), sinaicitin (3), (‐)‐globulol (4), β‐caryolanol (5), phytol (6), biochanin A (7), chrysoeriol (8), tanoside II (9) and astragalin (10) using NMR and MS spectral data. Among the isolates, (7”R, 8”R)‐hydnocarpin (2) showed good cytotoxic activity against KB, HepG‐2, Lu and MCF‐7 cancer cell lines with IC50 values from 13.99±0.62 μg/mL to 30.65±1.44 μg/mL. Compound 4 showed selective cytotoxicity against LU cancer cell line and significant acetylcholinesterase (AChE) inhibition with IC50 values of 12.31±0.51 μg/mL and 5.12±0.22 μg/mL, respectively.

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Chemical Composition and Antimicrobial Activity of Essential Oil from the Leaves and Twigs of Knema tonkinensis

Huong,

Dang,

Hai

et al. 2024

Chem Nat Compd

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Bioactive flavonoids from Knema elegans

Cited by 7 publications

References 25 publications

Flavonoids and other constituents of plants from the genus Knema (Myristicaceae) and their pharmacological studies: An updated review

Flavonoids and other constituents of plants from the genus Knema (Myristicaceae) and their pharmacological studies: An updated review

Secondary metabolites from leaves of Knema pachycarpa possessing cytotoxic and acetylcholinesterase inhibitory activities

Chemical Composition and Antimicrobial Activity of Essential Oil from the Leaves and Twigs of Knema tonkinensis

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