Bioactive glass S53P4 as bone graft substitute in treatment of osteomyelitis

Reprint of: Review of bioactive glass: From Hench to hybrids

“…After 11 years, the fusion rate for the glass was 88% compared to 100% for autograft [38]. Similar results were seen for treatment of osteomyelitis, where the bone quality of the vertebrae is reduced due to bacterial infection [39]. BonAlive was also compared to autograft in the same patient in spondylodesis procedures for treatment of spine burst fractures.…”

In vitro study of nano-sized zinc doped bioactive glass

“…Bioceramics such as Al 2 O 3 [1], ZrO 2 [2], hydroxyapatite [3], bioactive glass [4], glasseceramics ApatiteeWollastonite [5] and tricalcium phosphates [6] have been extensively studied as they are often used to repair damaged mammalian hard tissue. Out of these bioceramics, hydroxyapatite and bioactive glass have received special attention due to their enhanced bone-bonding ability.…”

“…The solegel method has several advantages over melt-quenching method: (1) reaction takes places at lower temperature [20]; (2) volatile component such as P 2 O 5 are less likely to evaporate during lower-temperature processing [20]; (3) the range of glass composition that is bioactive increases eg. up to 90 mol% silica based sole gel derived bioactive glasses are bioactive compared to the upper limit of 60 mol% silica of melt-derived bioactive glass [21]; (4) gives homogeneous mixture in the final product [20]. Bioactive glasses of various compositions synthesized by solegel method have shown minimal inflammatory response [22e24] and promote bone regeneration [25,26].…”

Silicon oxide based materials for controlled release in orthopedic procedures

“…In a multicenter study [170], 11 patients with verified chronic osteomyelitis in the lower extremity and the spine bioactive glass S53P4 was used as synthetic bone graft. At a mean follow-up period of 24 months (range 10-38 months), the glass was found to be well tolerated, and nine patients healed without complications.…”