Bioactive Glasses for Cancer Therapy

Lin, Yi-Nan; Mauro, John C.; Kaur, Gurbinder

doi:10.1016/b978-0-08-102196-5.00010-0

Cited by 8 publications

(8 citation statements)

References 105 publications

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“…The synergistic effects of Si, Ca and P ions released from BG, could promote differentiation of osteoblasts via activation of osteogenesis-related signaling pathways 7 . Magnetic BGs are also reported having potential for hyperthermia treatment of malignant tumors, including bone cancer 8 . Interestingly, BGs have been clinically used to treat damages made by periodontal disease 9 as well as for ocular surgery applications 10 .…”

Section: Introductionmentioning

confidence: 99%

Effects of strontium ions with potential antibacterial activity on in vivo bone regeneration

Baheiraei

Eyni

Bakhshi

et al. 2021

Sci Rep

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Bioactive glasses (BGs) have attracted added attention in the structure of the scaffolds for bone repair applications. Different metal ions could be doped in BGs to induce specific biological responses. Among these ions, strontium (Sr) is considered as an effective and safe doping element with promising effects on bone formation and regeneration. In this experiment, we evaluated the antibacterial activities of the gelatin-BG (Gel-BG) and Gel-BG/Sr scaffolds in vitro. The osteogenic properties of the prepared scaffolds were also assessed in rabbit calvarial bone defects for 12 weeks. Both scaffolds showed in vivo bone formation during 12 weeks with the newly formed bone area in Gel-BG/Sr scaffold was higher than that in Gel-BG scaffolds after the whole period. Based on the histological results, Gel-BG/Sr exhibited acceleration of early-stage bone formation in vivo. The results of antibacterial investigation for both scaffolds showed complete growth inhibition against Escherichia coli (E. coli). Although Gel-BG revealed no antibacterial effect on Staphylococcus aureus (S. aureus), the Gel-BG/Sr was able to partially inhibit the growth of S. aureus, as detected by threefold reduction in growth index. Our results confirmed that Sr doped BG is a favorable candidate for bone tissue engineering with superior antibacterial activity and bone regeneration capacity compared with similar counterparts having no Sr ion.

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Section: Introductionmentioning

confidence: 99%

Effects of strontium ions with potential antibacterial activity on in vivo bone regeneration

Baheiraei

Eyni

Bakhshi

et al. 2021

Sci Rep

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“…35,39 In order to avoid the production of undesirable radioisotopes from highly soluble K and Ca with a long half-life (1.25 × 10 9 years and 162.7 days, respectively) during neutron activation processes, an REAS system was studied by Day et al in the early 1980s. 35,40,41 REAS consists of three oxides (Al 2 O 3 -SiO 2 -RE 2 O 3 , where RE 2 O 3 is the neutron-activated rare-earth oxide) and is a good candidate for radiotherapy agents due to the fast decay of radioisotope produced during neutron activation processes. Furthermore, these glasses have excellent durability in the biological environment and do not release any 2C).…”

Section: Radiotherapymentioning

confidence: 99%

A critical review of bioactive glasses and glass–ceramics in cancer therapy

Moeini

Chinijani

Khachatourian

et al. 2022

Int J of Appl Glass Sci

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There is an ongoing profound shift in using glass as a primarily passive material to one that instills active properties. We believe and demonstrate that bioactive glasses (BGs) and glass–ceramics (BGCs) as functional biomaterials for cancer therapy can transform the world of healthcare in the 21st century. Melt/gel‐derived BGs and BGCs can carry many exotic elements, including less common rare‐earth, and trigger highly efficient anticancer properties via the combination of radiotherapy, photothermal therapy, magnetic hyperthermia, along with drug or therapeutic ions delivery. The addition of these dopants modifies the bioactivity, imparts novel functionalities, and induces specific biological effects that are not achievable using other classes of biomaterials. In this paper, we have briefly reviewed and discussed the current knowledge on promising compositions, processing parameters, and applications of BGs and BGCs in treating cancer. We also envisage the need for further research on this particular, unique class of BGs and BGCs.

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“…The most common side effects of radiation therapy include patient’s fatigue, alopecia, skin burns, nausea, diarrhea, and risk of secondary cancers due to ionization in healthy cells and tissues [ 19 ].…”

Section: Radiation Therapy: a Short Overviewmentioning

confidence: 99%

Biomedical Radioactive Glasses for Brachytherapy

et al. 2021

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The fight against cancer is an old challenge for mankind. Apart from surgery and chemotherapy, which are the most common treatments, use of radiation represents a promising, less invasive strategy that can be performed both from the outside or inside the body. The latter approach, also known as brachytherapy, relies on the use of implantable beta-emitting seeds or microspheres for killing cancer cells. A set of radioactive glasses have been developed for this purpose but their clinical use is still mainly limited to liver cancer. This review paper provides a picture of the biomedical glasses developed and experimented for brachytherapy so far, focusing the discussion on the production methods and current limitations of the available options to their diffusion in clinical practice. Highly-durable neutron-activatable glasses in the yttria-alumina-silica oxide system are typically preferred in order to avoid the potentially-dangerous release of radioisotopes, while the compositional design of degradable glass systems suitable for use in radiotherapy still remains a challenge and would deserve further investigation in the near future.

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Bioactive Glasses for Cancer Therapy

Cited by 8 publications

References 105 publications

Effects of strontium ions with potential antibacterial activity on in vivo bone regeneration

Effects of strontium ions with potential antibacterial activity on in vivo bone regeneration

A critical review of bioactive glasses and glass–ceramics in cancer therapy

Biomedical Radioactive Glasses for Brachytherapy

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