Bioactive milk peptides: an updated comprehensive overview and database

Nielsen, Søren Drud-Heydary; Liang, Ningjian; Rathish, Harith; Kim, Bum Jin; Lueangsakulthai, Jiraporn; Koh, Jeewon; Qu, Yunyao; Schulz, Hans-Jörg; Dallas, David C.

doi:10.1080/10408398.2023.2240396

Cited by 24 publications

(8 citation statements)

References 159 publications

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“…Potentially bioactive peptides were identified by searching the obtained list of peptides present in the peptidome against the milk bioactive peptide database (MBPDB), using a similarity of 80% as a criterion [15]. The potential bioactive peptides were grouped according to their bioactivity, and a list of summarized relative abundancies in percentages for the identified bioactivities was generated.…”

Section: Bioactive Peptidesmentioning

confidence: 99%

“…The peptides in the peptidome were searched for known bioactive peptides in the milk bioactive peptide database (MBPDB) [15]. A similarity score of 80% was used.…”

Section: Bioactive Peptidesmentioning

confidence: 99%

“…The 13,158 identified peptides in the peptidome were searched against the MBPDP by Nielsen et al [15]. In total, 282 bioactive peptides were identified with 402 different bioactivities, thus some were either known or 80%, or more, similar to multiple different bioactivities.…”

Section: Bioactive Peptidesmentioning

confidence: 99%

“…This pre-digestion of the HM proteins was suggested to aid the infant in the digestion of proteins and, thus, increase the nutritional uptake by the infant. A beneficial effect of this pre-digestion is also the generation of bioactive peptides, where a wide variety of these are known [15]. Furthermore, the profile of bioactive peptides is also known to differ between term and pre-term infants [16].…”

Section: Introductionmentioning

confidence: 99%

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Fingerprinting of Proteases, Protease Inhibitors and Indigenous Peptides in Human Milk

Thesbjerg,

Nielsen,

Sundekilde

et al. 2023

Nutrients

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The presence of proteases and their resulting level of activity on human milk (HM) proteins may aid in the generation of indigenous peptides as part of a pre-digestion process, of which some have potential bioactivity for the infant. The present study investigated the relative abundance of indigenous peptides and their cleavage products in relation to the abundance of observed proteases and protease inhibitors. The proteomes and peptidomes in twelve HM samples, representing six donors at lactation months 1 and 3, were profiled. In the proteome, 39 proteases and 29 protease inhibitors were identified in 2/3 of the samples. Cathepsin D was found to be present in higher abundance in the proteome compared with plasmin, while peptides originating from plasmin cleavage were more abundant than peptides from cathepsin D cleavage. As both proteases are present as a system of pro- and active- forms, their activation indexes were calculated. Plasmin was more active in lactation month 3 than month 1, which correlated with the total relative abundance of the cleavage product ascribed to plasmin. By searching the identified indigenous peptides in the milk bioactive peptide database, 283 peptides were ascribed to 10 groups of bioactivities. Antimicrobial peptides were significantly more abundant in month 1 than month 3; this group comprised 103 peptides, originating from the β-CN C-terminal region.

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Section: Bioactive Peptidesmentioning

confidence: 99%

“…The peptides in the peptidome were searched for known bioactive peptides in the milk bioactive peptide database (MBPDB) [15]. A similarity score of 80% was used.…”

Section: Bioactive Peptidesmentioning

confidence: 99%

Section: Bioactive Peptidesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Fingerprinting of Proteases, Protease Inhibitors and Indigenous Peptides in Human Milk

Thesbjerg,

Nielsen,

Sundekilde

et al. 2023

Nutrients

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“…In this context, human and bovine milk contain a myriad of bioactive peptides, which provide remarkable health benefits [ 8 , 9 , 10 ]. For example, many of these milk constituents are endowed with advantageous properties and physiological functions, resulting in tangible benefits such as calcium absorption, bone health, improved immunity and protection against infections [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Glycomacropeptide as an Efficient Agent to Fight Pathophysiological Mechanisms of Metabolic Syndrome

Sauvé,

Feldman,

Sané

et al. 2024

Nutrients

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There is currently a growing interest in the use of nutraceuticals as a means of preventing the development of complex diseases. Given the considerable health potential of milk-derived peptides, the aim of this study was to investigate the protective effects of glycomacropeptide (GMP) on metabolic syndrome. Particular emphasis was placed on the potential mechanisms mitigating cardiometabolic disorders in high-fat, high-fructose diet-fed mice in the presence of GMP or Bipro, an isocaloric control. The administration of GMP for 12 weeks reduced obesity, hyperglycemia and hyperinsulinemia caused by a high-fat, high-fructose diet, resulting in a decline in insulin resistance. GMP also lessened systemic inflammation, as indicated by decreased circulating inflammatory cytokines. In the intestinal and hepatic tissues, GMP improved homeostasis by increasing insulin sensitivity and attenuating high-fat, high-fructose-induced inflammation, oxidative stress and endoplasmic reticulum stress. Biochemical and histological analyses revealed improved hepatic steatosis and fatty acid composition in the livers of high-fat, high-fructose diet-fed mice treated with GMP compared to Bipro. A trend toward a decrease in bile acids without any marked changes in intestinal microbiota composition characterized GMP-treated animals compared to those administered Bipro. GMP offers considerable potential for fighting metabolic syndrome-related components and complications given its beneficial effects on risk factors such as inflammation, oxidative stress and endoplasmic reticulum stress without involving the intestinal microbiota.

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Bioactive peptides from livestock milk and casein as alternative functional foods

Hau,

Li,

Mah

2024

Food Safety and Health

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Bioactive milk peptides: an updated comprehensive overview and database

Cited by 24 publications

References 159 publications

Fingerprinting of Proteases, Protease Inhibitors and Indigenous Peptides in Human Milk

Fingerprinting of Proteases, Protease Inhibitors and Indigenous Peptides in Human Milk

Glycomacropeptide as an Efficient Agent to Fight Pathophysiological Mechanisms of Metabolic Syndrome

Bioactive peptides from livestock milk and casein as alternative functional foods

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