Bioactive Molecules from Sea Hares

Kamiya, Hisao; Sakai, Ryuichi; Jimbo, Mitsuru

doi:10.1007/978-3-540-30880-5_10

Cited by 38 publications

(29 citation statements)

References 98 publications

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“…LAOs in microorganisms appear to be involved in the utilization of ammonia as a nitrogen source, and those in animals show distinct biologic and physiologic effects such as antimicrobial activity, antiparasitic activity, apoptosis, cytotoxicity, edema, hemolysis, hemorrhage and platelet aggregation (Du and Clemeston 2002). Snake venom and mollusk LAOs have been well investigated (Du and Clemeston 2002;Kamiya et al 2006;Guo et al 2012). Those LAOs are homodimeric or homotetrameric with molecular masses of 110-340 kDa that consist of a 53-68 kDa subunit.…”

Section: -1 Reaction Of Laomentioning

confidence: 99%

“…In aquatic animals, LAO was first found from albumen gland of sea hare Aplysia kurodai as an antibacterial and antineoplastic factor named aplysianin A (Kamiya et al 1986(Kamiya et al , 2006Jimbo et al 2003). Following the work, LAOs have been identified from other species of sea hares such as Dolabella auricularia albumen gland (dolabellanin A) (Iijima et al 2003), A. punctata purple fluid (APIT) (Butzke et al 2004(Butzke et al , 2005 and A. californica ink (escapin) .…”

Section: -2 Lao In Fishmentioning

confidence: 99%

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L-Amino Acid Oxidase, a Novel Antibacterial Protein in the Rockfish <i>Sebastes schlegeli</i>

Kitani¹,

Ishizaki²,

Nagashima³

2015

Aqua-BioSci. Monogr. (ABSM)

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Section: -1 Reaction Of Laomentioning

confidence: 99%

Section: -2 Lao In Fishmentioning

confidence: 99%

L-Amino Acid Oxidase, a Novel Antibacterial Protein in the Rockfish <i>Sebastes schlegeli</i>

Kitani¹,

Ishizaki²,

Nagashima³

2015

Aqua-BioSci. Monogr. (ABSM)

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“…Another review in 2009 [21] focused on the chemistry and biology of aplyronines as actin-depolymerizing agents. Kamiya [22] and Miyamoto [23] also reviewed the secondary metabolites from Japanese sea hare.…”

Section: Introductionmentioning

confidence: 98%

“…This ink acts as a screen, while at the same time adversely affecting the smell sensors of predators [3]. Several defense substances have been investigated, such as a cytolytic factor from the purple fluid of the sea hare Aplysia kurodai, and antineoplastic glycoproteins from their eggs or albumen gland [4,5].…”

Section: Introductionmentioning

confidence: 99%

Antitumor Effects of Sea Hare-Derived Compounds in Cancer

Kigoshi

Kita

2014

Handbook of Anticancer Drugs From Marine Origin

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Sea hares (family Aplysiidae) are a rich source of bioactive substances. Especially, over the past 40 years, the genera Aplysia and Dolabella have afforded numerous bioactive secondary metabolites that exhibit antitumor activity. For example, the depsipeptide dolastatin 10 and its analogue are currently in cancer clinical trials. Meanwhile, the chemical probe approach has revealed that the antitumor macrolide aplyronine A inhibits microtubule assembly in association with actin. This article highlights the recent findings regarding the chemical biology of antitumor and antineoplastic compounds from sea hares, as well as molecules that have been discovered and characterized after 2000.Keywords Antitumor · Sea hare · Aplysia · Antitumor · Actin-deplymerization · Cytotoxicity · Tubulin IntroductionSea hares, which belong to the opisthobranch group of mollusks (clade Aplysiomorpha), are shell-less, slow-moving benthic marine mollusks [1]. The order Anaspidea includes two families, Akeridae and Aplysiidae [2]. Almost all chemical studies have focused on Aplysiidae specimens. The family Aplysiidae includes nine genera, Aplysia (Linnaeus 1767), Bursatella (Blainville 1817), Dolabella (Lamarck 1801), Dolabrifera (Gray 1847), Notarchus (Cuvier 1817), Petalifera (Gray 1847), Phyllaplysia (Fischer 1872), Syphonota (Adams 1854), and Stylocheilus (Gould 1852). Sea hares are herbivorous, and are typically found on seaweed in shallow water. They are not eaten by other marine animals and have been postulated to contain chemical defense substances. The poisonous properties of sea hare secretions were known in Roman times. In addition, sea hares release ink from their ink glands, which deter predators. This ink acts as a screen, while at the

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“…Passive chemical defenses are plentiful and effective, and include deterrent molecules in their skin and digestive gland (e.g. Carefoot, 1987;Johnson and Willows, 1999;Wägele and Klussmann-Kolb, 2005;Kamiya et al, 2006). Inking is an active, inducible chemical defense.…”

Section: Introductionmentioning

confidence: 99%

Defense through sensory inactivation: sea hare ink reduces sensory and motor responses of spiny lobsters to food odors

Love-Chezem

Aggio

Derby

2013

Journal of Experimental Biology

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SUMMARYAntipredator defenses are ubiquitous and diverse. Ink secretion of sea hares (Aplysia) is an antipredator defense acting through the chemical senses of predators by different mechanisms. The most common mechanism is ink acting as an unpalatable repellent. Less common is ink secretion acting as a decoy (phagomimic) that misdirects predatorsʼ attacks. In this study, we tested another possible mechanism -sensory inactivation -in which ink inactivates the predatorʼs reception of food odors associated with would-be prey. We tested this hypothesis using spiny lobsters, Panulirus argus, as model predators. Ink secretion is composed of two glandular products, one being opaline, a viscous substance containing concentrations of hundreds of millimolar of total free amino acids. Opaline sticks to antennules, mouthparts and other chemosensory appendages of lobsters, physically blocking access of food odors to the predatorʼs chemosensors, or over-stimulating (short term) and adapting (long term) the chemosensors. We tested the sensory inactivation hypotheses by treating the antennules with opaline and mimics of its physical and/or chemical properties. We compared the effects of these treatments on responses to a food odor for chemoreceptor neurons in isolated antennules, as a measure of effect on chemosensory input, and for antennular motor responses of intact lobsters, as a measure of effect on chemically driven motor behavior. Our results indicate that opaline reduces the output of chemosensors by physically blocking reception of and response to food odors, and this has an impact on motor responses of lobsters. This is the first experimental demonstration of inactivation of peripheral sensors as an antipredatory defense. Supplementary material available online at

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Bioactive Molecules from Sea Hares

Cited by 38 publications

References 98 publications

L-Amino Acid Oxidase, a Novel Antibacterial Protein in the Rockfish <i>Sebastes schlegeli</i>

L-Amino Acid Oxidase, a Novel Antibacterial Protein in the Rockfish <i>Sebastes schlegeli</i>

Antitumor Effects of Sea Hare-Derived Compounds in Cancer

Defense through sensory inactivation: sea hare ink reduces sensory and motor responses of spiny lobsters to food odors

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