Bioactive Moringa olifera seed extracts attenuates cholesterol gall stones in hyperglycaemic Swiss mice

Salami, Adeola Temitope; Okonkwo, Chioma E.; Attah, Alfred F.; Olagoke, Olawande C.

doi:10.1007/s00580-021-03206-3

Cited by 2 publications

(3 citation statements)

References 53 publications

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“…In SA, MO is farmed in several provinces, including Gauteng, Limpopo, Mpumalanga, and KwaZulu-Natal [ 115 ]. The MO tree is known for its anthelmintic, antiseptic, detergent, anti-ulcerogenic, anti-inflammatory, anti-microbial, antioxidant, anti-hyperglycaemic, anti-clastogenic, anticancer, and anti-fibrotic effects [ 8 ]. For centuries, many cultures worldwide have used MO to treat skin infections, blackheads, anxiety, anemia, asthma, bronchitis, catarrh, chest congestion, cholera, and many other illnesses [ 118 ].…”

Section: Prevalence Of Hiv/aidsmentioning

confidence: 99%

“…The Moringa oleifera (MO) tree from the family of Moringaceae is one such example of a medicinal plant; it has been used for centuries in traditional medicine [ 8 ]. MO’s traditional uses include healing skin infections, wounds, fever, diarrhea, and sore throats [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…MO’s traditional uses include healing skin infections, wounds, fever, diarrhea, and sore throats [ 9 ]. The MO tree is widely used due to its high concentration of phytochemicals that work synergistically to induce their medicinal effects [ 8 ]. Scientifically, MO is documented to possess anti-inflammatory, antihypertensive, antimicrobial, antioxidant, anti-diabetic, and antiviral effects [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

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The Hepatoprotective Effects of Moringa oleifera against Antiretroviral-Induced Cytotoxicity in HepG2 Cells: A Review

Saki,

De Villiers,

Ntsapi

et al. 2023

Plants

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The untreated human immunodeficiency virus (HIV), a lentivirus species that attacks immune cells (CD4+ T cells), causes acquired immunodeficiency syndrome (AIDS). HIV-positive people manage HIV/AIDS by using antiretroviral therapy (ART). The ART treatment regimen contains two nucleoside reverse transcriptase inhibitors (NRTIs) and one non-nucleoside reverse transcriptase inhibitor/integrase strand transfer inhibitor. Tenofovir, an NRTI approved for managing HIV infection, is associated with hepatic steatosis and lactic acidosis, which are linked to mitochondrial toxicity and oxidative stress. Due to side-effects associated with ART, people living with HIV often use medicinal plants or a combination of medicinal plants with ART to promote adherence and diminish the side-effects and cytotoxicity. The Moringa oleifera (MO) tree from the family of Moringaceae is among the medicinal trees studied in managing HIV/AIDS in sub-Saharan Africa. The MO tree extracts have been reported to have inhibitory activity primarily against HIV due to their bioactive compounds. However, there is a scarcity of knowledge about the use of the MO tree amongst HIV/AIDS patients receiving ART in South Africa and its effect on patient compliance and outcomes. Thus, this review aims to outline the impact of MO aqueous leaf extract on oxidative stress and antioxidant responses in human HepG2 liver cells after exposure to antiretrovirals such as tenofovir. The review will contribute to a comprehensive understanding of the potential protective effect of MO aqueous leaf extract on tenofovir-induced cytotoxicity.

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Section: Prevalence Of Hiv/aidsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%