Bioactive Nitrogenous Compounds from <i>Acorus tatarinowii</i>

Xu, Feng; Li, Haibo; Gao, Hao; Yan, Huang; Zhou, Wen; Yu, Yang; Yao, Xin‐Sheng

doi:10.1002/mrc.4393

Cited by 12 publications

(6 citation statements)

References 16 publications

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“…Acortatarins A and B were novel spiroalkaloids with naturally unusual morpholine motif reported by Tong's group in the same year (Tong et al 2010b). Novel azafluoranthene alkaloid named as tatarine D was isolated from ATS with two known alkaloids tatarine A and telitoxine (Feng et al 2016). …”

Section: Alkaloidsmentioning

confidence: 95%

“…Alkaloid acortatarins A could inhibit high-glucose-induced ROD generation in mesangial cells by almost 50% at the concentration of 10μM (Tong et al 2010c). Alkaloids tatarines A and D inhibited Aβ 42 aggregation with IC 50 values of 45.0 and 26.0 μM, respectively, while the IC 50 values of positive control epigallocatechin gallate (EGCG) were only 0.71 μM (Feng et al 2016).…”

Section: Activities Of the Novel Compounds From Atsmentioning

confidence: 99%

“…Tatarinan S is a C8-C9'-type neolignan, which was naturally obtained for the first time in 2016 (Luo et al 2016). New lignanamides were also reported such as tataramide B, tatarine E and acorusin A (Wang et al 1997, Feng et al 2016, Luo et al 2016). …”

Section: Lignansmentioning

confidence: 99%

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Constituents and Activities of Acorus tatarinowii

Yang

Yan

Chen

et al. 2017

MRAJ

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Section: Alkaloidsmentioning

confidence: 95%

Section: Activities Of the Novel Compounds From Atsmentioning

confidence: 99%

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Constituents and Activities of Acorus tatarinowii

Yang

Yan

Chen

et al. 2017

MRAJ

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“…The seeds of Datura metel had an intensive response signal in the SPR system targeted at TREM2, and four lignin-amides were identified that were regarded as TREM2 targeted active candidates by UPLC-MS analysis. Coincidentally, the lignan-amides demonstrated outstanding effects for AD treatment involving acetylcholinesterase inhibitory activity, anti-oxidation, and anti-inflammatory in previous modern pharmacological studies [ 12 , 13 , 14 , 15 , 16 ]. Simultaneously, the rich lignin-amides existed in the seeds of Datura metel including cannabisin D-H [ 17 , 18 , 19 , 20 ], and it possesses the traditional effects of the treatments of convulsion, epilepsy, and rheumatic arthralgia according to the Compendium of Materia Medica [ 3 ], together with analgesic, hypoglycemic, and anti-inflammation biological activities [ 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Discovery of Active Ingredients Targeted TREM2 by SPR Biosensor-UPLC/MS Recognition System, and Investigating the Mechanism of Anti-Neuroinflammatory Activity on the Lignin-Amides from Datura metel Seeds

Wang

Liu

et al. 2021

Molecules

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As a new target protein for Alzheimer’s disease (AD), the triggering receptor expressed on myeloid Cells 2 (TREM2) was expressed on the surface of microglia, which was shown to regulate neuroinflammation, be associated with a variety of neuropathologic, and regarded as a potential indicator for monitoring AD. In this study, a novel recognition system based on surface plasmon resonance (SPR) for the TREM2 target spot was established coupled with quadrupole time-of-flight tandem mass spectrometry (UPLC-MS), in order to screen the active ingredients targeting TREM2 from Datura metel seeds. The results showed that four lignan-amides were discovered as candidate compounds by SPR biosensor-UPLC/MS recognition analysis. According to the guidance of the active ingredients discovered by the system, the lignin-amides from Datura metel seeds (LDS) were preliminarily identified as containing 27 lignan-amides, which were enriched compositions by the HP-20 of Datura metel seeds. Meanwhile, the anti-inflammatory activity of LDS was evaluated in BV2 microglia induced by LPS. Our experimental results demonstrated that LDS could reduce NO release in LPS-treated BV2 microglia cells and significantly reduce the expression of the proteins of inducible Nitric Oxide Synthase (iNOS), cyclooxygenase 2 (COX-2), microtubule-associated protein tau (Tau), and ionized calcium-binding adapter molecule 1 (IBA-1). Accordingly, LDS might increase the expression of TREM2/DNAX-activating protein of 12 kDa (DAP12) and suppress the Toll-like receptor SX4 (TLR4) pathway and Recombinant NLR Family, Pyrin Domain Containing Protein 3 (NLRP3)/cysteinyl aspartate specific proteinase-1 (Caspase-1) inflammasome expression by LDS in LPS-induced BV2 microglial cells. Then, the inhibitory release of inflammatory factors Interleukin 1 beta (IL-1β), Interleukin 6 (IL-6), and Tumor necrosis factor-alpha (TNFα) inflammatory cytokines were detected to inhibit neuroinflammatory responses. The present results propose that LDS has potential as an anti-neuroinflammatory agent against microglia-mediated neuroinflammatory disorders.

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“…Acorus tatarinowii Schott is an Acoraceae perennial herb growing in wetlands and is widely distributed in eastern and southern Asia . Its rhizome is a famous traditional Chinese medicine, and it was recorded as the top-grade medicine in the most ancient Chinese materia medica book, “Shen Nong’s Herbal Classic” . In China, a water-dipped solution was historically used for curing forgetfulness, dementia, and apoplexy .…”

mentioning

confidence: 99%

Bioactive Asarone-Derived Phenylpropanoids from the Rhizome of Acorus tatarinowii Schott

Zhou

Zou

et al. 2017

J. Nat. Prod.

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Eight new (1a/1b, 2a, 3a, 4a/4b, and 5a/5b) and seven known (2b, 3b, and 6-10) asarone-derived phenylpropanoids, a known asarone-derived lignan (12), and four known lignan analogues (11 and 13-15) were isolated from the rhizome of Acorus tatarinowii Schott. The structures were elucidated via comprehensive spectroscopic analyses, modified Mosher's method, and quantum chemical calculations. Compounds 1-8 were present as enantiomers, and 1-5 were successfully resolved via chiral-phase HPLC. Compounds 1a/1b were the first cases of asarone-derived phenylpropanoids with an isopropyl C-3 side-chain tethered to a benzene core from nature. Hypoglycemic, antioxidant, and AChE inhibitory activities of 1-15 were assessed by the α-glucosidase inhibitory, ORAC, DPPH radical scavenging, and AChE inhibitory assays, respectively. All compounds except 3a showed α-glucosidase inhibitory activity. Compound 3b has the highest α-glucosidase inhibitory effect with an IC of 80.6 μM (positive drug acarbose IC of 442.4 μM). In the antioxidant assays, compounds 13-15 exhibited ORAC and DPPH radical scavenging activities. The results of the AChE inhibitory assay indicated that all compounds exhibited weak AChE inhibitory activities.

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Bioactive Nitrogenous Compounds from Acorus tatarinowii

Cited by 12 publications

References 16 publications

Constituents and Activities of Acorus tatarinowii

Constituents and Activities of Acorus tatarinowii

Discovery of Active Ingredients Targeted TREM2 by SPR Biosensor-UPLC/MS Recognition System, and Investigating the Mechanism of Anti-Neuroinflammatory Activity on the Lignin-Amides from Datura metel Seeds

Bioactive Asarone-Derived Phenylpropanoids from the Rhizome of Acorus tatarinowii Schott

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