Bioactive peptides: A review

Sánchez, Adrián; Vázquez, Alfredo Macías

doi:10.1093/fqs/fyx006

Cited by 523 publications

(256 citation statements)

References 182 publications

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“…Bioactivity. Aside from their nutritive values, proteins from both plant and animal sources have been hydrolytically converted to peptides that exhibit a wide range of bioactivity both in vitro and in vivo, for example, antioxidant, antihypertensive, antimicrobial, antithrombotic, hypocholesterolemic, mineral-binding, immunomodulatory, and cytomodulatory properties (Mine, Li-Chan, & Jiang, 2010;Sánchez & Vázquez, 2017;Sharma, Singh, & Rana, 2011). Enzymatic digestion of proteins can break down long polypeptide chains into short fragments that fit in, hence, disrupt the specific active site of the disease-related metabolic enzymes.…”

Section: Health Benefitsmentioning

confidence: 99%

Processing, Nutrition, and Functionality of Hempseed Protein: A Review

Wang

Xiong

2019

Comp Rev Food Sci Food Safe

176

107

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The increasing demand for plant proteins, along with rising awareness of the nutritional and functional roles of dietary proteins, has prompted the nutrition and food industry to explore nontraditional protein sources. Hempseed protein with its excellent nutritional value and superior digestibility has drawn great interest in both scientific and industrial fields. In this review, the chemistry and nutritional quality of hempseed protein and the health benefits of bioactive peptides derived thereof are highlighted. Processing, functionality, and application of various hemp protein products, including hempseed meal, hemp protein concentrates, and hemp protein isolates, are discussed. Moreover, recent advances in technological innovation to improve hempseed protein functionality are introduced. The objective of this review is to provide an updated summary of the research on hempseed protein and to fill the knowledge gap in the exploitation of potential nutritional, health, and processing benefits of this emerging protein source.

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Section: Health Benefitsmentioning

confidence: 99%

Processing, Nutrition, and Functionality of Hempseed Protein: A Review

Wang

Xiong

2019

Comp Rev Food Sci Food Safe

176

107

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“…Bioactive peptides derived from cyclic peptides, such as different classes of defensins (Jenssen, Hamill, & Hancock, 2006), were also included in the analysis (Table S2). Peptide hormones are usually a better source of bioactive peptides in plants (Maestri, Marmiroli, & Marmiroli, 2016;Sánchez & Vázquez, 2017;Schaller, 2001) compared to animals, where hormones, such as insulin, glucagon, and so on, are ubiquitinated and their constituent AAs are used for synthesis of other endogenous peptides and proteins (Ferro, Hyslop, & Camargo, 2004;Glickman & Ciechanover, 2002).…”

Section: Introductionmentioning

confidence: 99%

Meta‐Analysis for Correlating Structure of Bioactive Peptides in Foods of Animal Origin with Regard to Effect and Stability

Maestri

Pavlićević

Montorsi

et al. 2018

Comp Rev Food Sci Food Safe

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Amino acid (AA) sequences of 807 bioactive peptides from foods of animal origin were examined in order to correlate peptide structure with activity (antihypertensive, antioxidative, immunomodulatory, antimicrobial, hypolipidemic, antithrombotic, and opioid) and stability in vivo. Food sources, such as milk, meat, eggs, and marine products, show different frequencies of bioactive peptides exhibiting specific effects. There is a correlation of peptide structure and effect, depending on type and position of AA. Opioid peptides contain a high percentage of aromatic AA residues, while antimicrobial peptides show an excess of positively charged AAs. AA residue position is significant, with those in the first and penultimate positions having the biggest effects on peptide activity. Peptides that have activity in vivo contain a high percentage (67%) of proline residues, but the positions of proline in the sequence depend on the length of the peptide. We also discuss the influence of processing on activity of these peptides, as well as methods for predicting release from the source protein and activity of peptides.

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“…Food-derived bioactive peptides with potential use as nutraceuticals and health supplement have increased interests of nutraceutical industries (S anchez & V azquez, 2017;Zieli nska et al, 2018). In spite of the significant progress in the isolation and purification of bioactive peptides from several natural sources, there are still several limitations in obtaining and purifying sufficient quantity of bioactive peptide fractions to perform the human trial at a large scale without losing activity (O'Keeffe et al, 2017;Shen & Matsui, 2017).…”

mentioning

confidence: 99%