Bioactive peptides for boosting stem cell culture platform: Methods and applications

Dayem, Ahmed Abdal; Lee, Soo Bin; Lim, Kyung Min; Kim, Aram; Shin, Hyun Jin; Vellingiri, Balachandar; Kim, Young Bong; Cho, Ssang-Goo

doi:10.1016/j.biopha.2023.114376

Cited by 14 publications

(11 citation statements)

References 285 publications

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“…Furthermore, biomaterials can carry active ingredients such as drugs, peptides, and growth factors. These components can influence cell growth, migration, and secretion, thereby further enhancing their role in promoting wound healing[ 173 , 174 ] (Figure 3 ).…”

Section: Interaction Between Scaffolds and Mscsmentioning

confidence: 99%

“…In addition to drugs and cellular factors, bioactive peptides can significantly enhance stem cell adhesion, proliferation, and targeted differentiation. These peptides can be immobilized on culture plates or attached to scaffolds, such as hydrogels or synthetic matrices[ 174 ]. Jose et al [ 179 ] investigated the ability of glycine-histidine-lysine (GHK) to boost the secretion of pro-angiogenic factors from human MSC in culture and when covalently linked to alginate hydrogels.…”

Section: Interaction Between Scaffolds and Mscsmentioning

confidence: 99%

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Biological scaffold as potential platforms for stem cells: Current development and applications in wound healing

Xiang,

Kang,

et al. 2024

World J Stem Cells

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Wound repair is a complex challenge for both clinical practitioners and researchers. Conventional approaches for wound repair have several limitations. Stem cell-based therapy has emerged as a novel strategy to address this issue, exhibiting significant potential for enhancing wound healing rates, improving wound quality, and promoting skin regeneration. However, the use of stem cells in skin regeneration presents several challenges. Recently, stem cells and biomaterials have been identified as crucial components of the wound-healing process. Combination therapy involving the development of biocompatible scaffolds, accompanying cells, multiple biological factors, and structures resembling the natural extracellular matrix (ECM) has gained considerable attention. Biological scaffolds encompass a range of biomaterials that serve as platforms for seeding stem cells, providing them with an environment conducive to growth, similar to that of the ECM. These scaffolds facilitate the delivery and application of stem cells for tissue regeneration and wound healing. This article provides a comprehensive review of the current developments and applications of biological scaffolds for stem cells in wound healing, emphasizing their capacity to facilitate stem cell adhesion, proliferation, differentiation, and paracrine functions. Additionally, we identify the pivotal characteristics of the scaffolds that contribute to enhanced cellular activity.

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Section: Interaction Between Scaffolds and Mscsmentioning

confidence: 99%

Section: Interaction Between Scaffolds and Mscsmentioning

confidence: 99%

Biological scaffold as potential platforms for stem cells: Current development and applications in wound healing

Xiang,

Kang,

et al. 2024

World J Stem Cells

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“…Accordingly, the use of collagen type I matrices as a cost-effective and low immunogenicity biomimetic substitute for the EHS matrix has gained popularity in in vitro cancer organoid modeling. Collagen, often obtained from animal sources, poses comparable limitations as EHS matrix, which include variation between batches, restricted tunability in both biochemical and mechanical properties, and contamination with undefined and xenogenic elements ( 5 , 107 ). Moreover, the microstructure of the collagen hydrogel, including fibril alignment and diameter, is highly influenced by the rate of temperature and pH change during the gelation process ( 117 ).…”

Section: Three-dimensional Matricesmentioning

confidence: 99%

Toward reproducible tumor organoid culture: focusing on primary liver cancer

Guo,

Li,

Gong

2024

Front. Immunol.

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Organoids present substantial potential for pushing forward preclinical research and personalized medicine by accurately recapitulating tissue and tumor heterogeneity in vitro. However, the lack of standardized protocols for cancer organoid culture has hindered reproducibility. This paper comprehensively reviews the current challenges associated with cancer organoid culture and highlights recent multidisciplinary advancements in the field with a specific focus on standardizing liver cancer organoid culture. We discuss the non-standardized aspects, including tissue sources, processing techniques, medium formulations, and matrix materials, that contribute to technical variability. Furthermore, we emphasize the need to establish reproducible platforms that accurately preserve the genetic, proteomic, morphological, and pharmacotypic features of the parent tumor. At the end of each section, our focus shifts to organoid culture standardization in primary liver cancer. By addressing these challenges, we can enhance the reproducibility and clinical translation of cancer organoid systems, enabling their potential applications in precision medicine, drug screening, and preclinical research.

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“…Inspired by the specific cell-adhesive interactions, various cell-binding peptides have been used for cell-adhesive modification of hydrogel bioadhesives. [12,13,88,89] While biopolymer-based bioadhesives allow cells to attach, most synthetic bioadhesives used in clinics lack cell adhesion ligands, as exemplified by PEG hydrogels used in COSEAL and DURASEAL. In general, many types of cells cannot directly attach to PEG hydrogels, resulting in low viability when encapsulated in these hydrogels.…”

Section: Cell Adhesion Ligandsmentioning

confidence: 99%

“…Inspired by the specific cell‐adhesive interactions, various cell‐binding peptides have been used for cell‐adhesive modification of hydrogel bioadhesives. [ 12,13,88,89 ]…”

Section: Biological Design Considerationsmentioning

confidence: 99%

Designing Regenerative Bioadhesives for Tissue Repair and Regeneration

Liu

et al. 2023

Advanced Therapeutics

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Tissue loss through injury, surgery, and disease motivates the development of new biomaterials to enable tissue repair and regeneration. Emerging at the interface between bioadhesives and regenerative medicine, a new generation of regenerative bioadhesives is created to possess dual functions of seamless tissue adhesion and effective tissue repair. This bioadhesive innovation has wide clinical applications, ranging from wound management to the regeneration of musculoskeletal tissues such as tendons and intervertebral discs. This perspective covers the design principles of regenerative bioadhesives in considering both mechanical and biological elements. Case studies of regenerative bioadhesives for load‐bearing organs such as skin, tendon, and intervertebral discs are presented here. Finally, immediate opportunities and future perspectives are outlined to further advance the field of regenerative bioadhesives.

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Bioactive peptides for boosting stem cell culture platform: Methods and applications

Cited by 14 publications

References 285 publications

Biological scaffold as potential platforms for stem cells: Current development and applications in wound healing

Biological scaffold as potential platforms for stem cells: Current development and applications in wound healing

Toward reproducible tumor organoid culture: focusing on primary liver cancer

Designing Regenerative Bioadhesives for Tissue Repair and Regeneration

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