Bioactive peptides from amaranth seed protein hydrolysates induced apoptosis and antimigratory effects in breast cancer cells

Taniya, M.S.; Mv, Reshma; Ps, Shanimol; Krishnan, Gayatri; Priya, Sulochana

doi:10.1016/j.fbio.2020.100588

Cited by 54 publications

(19 citation statements)

References 26 publications

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“…In addition to inducing cancer cell apoptosis, peptides from amaranth seed protein hydrolysates exhibit the antimetastatic ability of cancer cells in vitro. 83 Moreover, peptides or protein hydrolysates from leaves of Azadirachta indica, 84 protein-rich soybean (Glycine max), 85 sorghum kafirin, 86 and wheat germ 87 all have anticancer activity.…”

Section: Cytomodulatory and Anticancer Activitymentioning

confidence: 99%

Bioactive peptides of plant origin: distribution, functionality, and evidence of benefits in food and health

et al. 2022

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Section: Cytomodulatory and Anticancer Activitymentioning

confidence: 99%

Bioactive peptides of plant origin: distribution, functionality, and evidence of benefits in food and health

et al. 2022

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“…A novel antioxidative peptide SMRKPPG was successfully purified and identified from peony ( P. suffruticos ) seed protein hydrolysate; the peptide exhibited effective antioxidative capacity in vitro [ 187 ]. The protein hydrolysate purified from amaranth ( Amaranthus ) seeds was shown to have antioxidant activity and anticancer potential against breast cancer cells [ 190 ]. Chia ( S. hispanica ) seeds are known for their high antioxidant capacity, which is related to the high content of phenolic compounds [ 191 ].…”

Section: New Alternative Sources Of Peptidesmentioning

confidence: 99%

Current Trends of Bioactive Peptides—New Sources and Therapeutic Effect

Jakubczyk

Karaś

Rybczyńska‐Tkaczyk

et al. 2020

Foods

164

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Generally, bioactive peptides are natural compounds of food or part of protein that are inactive in the precursor molecule. However, they may be active after hydrolysis and can be transported to the active site. Biologically active peptides can also be synthesized chemically and characterized. Peptides have many properties, including antihypertensive, antioxidant, antimicrobial, anticoagulant, and chelating effects. They are also responsible for the taste of food or for the inhibition of enzymes involved in the development of diseases. The scientific literature has described many peptides with bioactive properties obtained from different sources. Information about the structure, origin, and properties of peptides can also be found in many databases. This review will describe peptides inhibiting the development of current diseases, peptides with antimicrobial properties, and new alternative sources of peptides based on the current knowledge and documentation of their bioactivity. All these issues are part of modern research on peptides and their use in current health or technological problems in food production.

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“…In addition, another study reported the anti-cancer potential of quinoa peptides, i.e., IFQEYI, DVYSPEAG, RELGEWGI (F-3), DKDYPK (F-2), and LWREGM (F-1), using human colorectal cancer cell lines [118]. Taniya et al [119] also reported the anti-cancer property of an amaranth seed protein hydrolysate. The hydrolysate was formed by simulated GIT digestion and further evaluated for anti-cancer effect using an in vitro breast cancer cell model.…”

Section: Seeds Bioactive Peptides/protein Hydrolysates Activities Referencesmentioning

confidence: 99%

Production, Purification, and Potential Health Applications of Edible Seeds’ Bioactive Peptides: A Concise Review

Samtiya

Acharya²,

Pandey³

et al. 2021

Foods

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Edible seeds play a significant role in contributing essential nutritional needs and impart several health benefits to improve the quality of human life. Previous literature evidence has confirmed that edible seed proteins, their enzymatic hydrolysates, and bioactive peptides (BAPs) have proven and potential attributes to ameliorate numerous chronic disorders through the modulation of activities of several molecular markers. Edible seed-derived proteins and peptides have gained much interest from researchers worldwide as ingredients to formulate therapeutic functional foods and nutraceuticals. In this review, four main methods are discussed (enzymatic hydrolysis, gastrointestinal digestion, fermentation, and genetic engineering) that are used for the production of BAPs, including their purification and characterization. This article’s main aim is to provide current knowledge regarding several health-promoting properties of edible seed BAPs in terms of antihypertensive, anti-cancer, antioxidative, anti-inflammatory, and hypoglycemic activities.

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Bioactive peptides from amaranth seed protein hydrolysates induced apoptosis and antimigratory effects in breast cancer cells

Cited by 54 publications

References 26 publications

Bioactive peptides of plant origin: distribution, functionality, and evidence of benefits in food and health

Bioactive peptides of plant origin: distribution, functionality, and evidence of benefits in food and health

Current Trends of Bioactive Peptides—New Sources and Therapeutic Effect

Production, Purification, and Potential Health Applications of Edible Seeds’ Bioactive Peptides: A Concise Review

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