Bioactive Phoenix dactylifera seeds incorporated chitosan/hydroxyapatite nanoconjugate for prospective bone tissue engineering applications: A bio-synergistic approach

Nanocomposite Materials Developed from Nano‐hydroxyapatite Impregnated Chitosan/κ‐Carrageenan for Bone Tissue Engineering.

“…Nanocomposites as bone‐implants should have bioactive surfaces to form of an apatite layer to bind with the bone tissue [29] . To examine the nHAp/CHI and nHAp/CHI/κ‐CGN nanocomposites ability to induce the formation of the apatite layer on their surfaces, the in vitro biomineralization study was carried out by incubating the nanocomposites for 30 days in simulated body fluid (SBF) solution.…”

“…Nanocomposites as bone-implants should have bioactive surfaces to form of an apatite layer to bind with the bone tissue. [29] To examine the nHAp/CHI and nHAp/CHI/k-CGN nanocomposites ability to induce the formation of the apatite layer on their surfaces, the in vitro biomineralization study was carried out by incubating the nanocomposites for 30 days in simulated body fluid (SBF) solution. The SEM micrographs showing the morphological changes on the surfaces of the nanocomposites after mineralization are given in Figure 4(c and d), where the nHAp/CHI/k-CGN nanocomposite SEM image (Figure 4c) exhibits much thicker layer of newly formed hydroxyapatite compared to nHAp/CHI nanocomposite (Fig- ure 4d).…”

“…The addition of a third component for creating a better nano-product with advanced properties relative to nanohydroxyapatite/chitosan nanocomposites has captivated global attention in the recent past. A number of natural products like collagen, [15] gelatin, [16,17] carboxymethyl cellulose, [18,19] carbon nanotube, [20] silk-sericin, [21] montmorillonite, [22] tamarind seed polysaccharide, [23] Trigonella foenum graecum seed polysaccharide, [24] bael fruit gum, [25] Euryale ferox, [26] xanthan gum, [27] resol, [28] Phoenix dactylifera seeds, [29] Bamboo fibre [30] etc. have been combined with chitosan/nano-hydroxyapatite to form more effective tri-component systems for bone tissue engineering applications.…”

Synthesis and characterization of β-cyclodextrin/carboxymethyl chitosan/hydroxyapatite fused with date seed extract nanocomposite scaffolds for regenerative bone tissue engineering

“…Hydroxyapatite nanoparticles (NHA) were synthesized by chemical precipitation as reported in our previous studies. 19,25 The so obtained product was subjected to ball milling to decrease the average size of the particles for the formation of crystalline NHA.…”

Surface configuration of microarc oxidized Ti with regionally loaded chitosan hydrogel containing ciprofloxacin for improving biological performance

“…Although the drug loaded chitosan hydrogel coating can endow Ti with excellent antibacterial ability, it hinders the bonding between implants and tissues during bone repair [ 20 ]. Particularly, a gap would be left at the interface after the degradation of the hydrogel [ 21 ], leading to failure of the surgery.…”