Bioactive phospho-therapy with black phosphorus for <i>in vivo</i> tumor suppression

Geng, Shengyong; Pan, Ting; Zhou, Wenhua; Cui, Haodong; Wu, Lie; Li, Zhibin; Chu, Paul K.; Yu, Xue‐Feng

doi:10.7150/thno.43092

Cited by 36 publications

(58 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Three tumor‐bearing mice received intravenous injections of TiSe 2 NSs (8 mg kg −1 , 100 µL), and the Se content in the tumors (8 and 12 h) was analyzed alone based on previous studies. [ 22,72 ] The concentration of Se at 8 h (10.65 µg g −1 ) was lower than that at 12 h (11.80 µg g −1 ); therefore, 12 h post‐injection was chosen as the time‐point for NIR laser irradiation. Then, the mice were also anesthetized and sacrificed at different time‐points post‐injection (12 h, 1 day, 3 days, 7 days, and 14 days).…”

Section: Resultsmentioning

confidence: 99%

Photothermal and Enhanced Photocatalytic Therapies Conduce to Synergistic Anticancer Phototherapy with Biodegradable Titanium Diselenide Nanosheets

Duo

Luo

et al. 2021

Small

View full text Add to dashboard Cite

Photothermal therapy (PTT) and photocatalytic therapy using near-infrared (NIR) laser radiation, which provide high specificity and efficiency, have gained extensive attention as noninvasive treatments for tumor destruction. PTT uses photo-absorbers with high photothermal conversion efficiency to convert light into heat and kill cancer cells via an increase in temperature. PTT requires temperatures over 50 °C to effectively destroy cancer cells. [2] Although such high temperatures may also cause thermal damage to healthy neighboring tissues owing to laser-induced nonspecific heat diffusion, [3] and high temperatures also cause cancer cells to release intracellular molecules that promote immunosuppression, which allows tumor immune escape, metastasis, invasion, and so on, [4] PTT is still an efficient method for obliterating cancer cells thoroughly. However, PTT is combined with other therapeutic approaches could achieve better therapeutic effects.As a novel photo-activated treatment, catalytic medicine has attracted increased attention in recent years for the management of many diseases. This technique allows specific bio-imaging and the administration of versatile therapies through physicochemical effects such as catalytic activity and energy conversion. Photo-activated metal complexes have been suggested to have remarkable potential for cancer treatment. [5][6][7][8] For instance, photocatalysis induces water Nanomaterial-based photothermal and photocatalytic therapies are effective against various types of cancers. However, combining two or more materials is considered necessary to achieve the synergistic anticancer effects of photothermal and photocatalytic therapy, which made the preparation process complicated. Herein, the authors describe simple 2D titanium diselenide (TiSe 2 ) nanosheets (NSs) that can couple photothermal therapy with photocatalytic therapy. The TiSe 2 NSs are prepared using a liquid exfoliation method. They show a layered structure and possess high photothermal conversion efficiency (65.58%) and good biocompatibility. Notably, upon near-infrared irradiation, these NSs exhibit good photocatalytic properties with enhanced reactive oxygen species generation and H 2 O 2 decomposition in vitro. They can also achieve high temperatures, with heat improving their catalytic ability to further amplify oxidative stress and glutathione depletion in cancer cells. Furthermore, molecular mechanism studies reveal that the synergistic effects of photothermal and enhanced photocatalytic therapy can simultaneously lead to apoptosis and necrosis in cancer cells via the HSP90/JAK3/NF-κB/IKB-α/ Caspase-3 pathway. Systemic exploration reveals that the TiSe 2 NSs has an appreciable degradation rate and accumulates passively in tumor tissue, where they facilitate photothermal and photocatalytic effects without obvious toxicity. Their study thus indicates the high potential of biodegradable TiSe 2 NSs in synergistic phototherapy for cancer treatment.

show abstract

Section: Resultsmentioning

confidence: 99%

Photothermal and Enhanced Photocatalytic Therapies Conduce to Synergistic Anticancer Phototherapy with Biodegradable Titanium Diselenide Nanosheets

Duo

Luo

et al. 2021

Small

View full text Add to dashboard Cite

show abstract

“…Besides their excellent physical characteristics, BPNSs also exhibit chemical reactivity toward ROS [130]. The layer-packed structure of BPNSs promotes the electron transfer as well as the oxidative reaction, leading to the excellent capability of scavenging ROS [131]. Previously, the roles of BPNSs as antioxidants were examined in an AKI murine model [130].…”

Section: Black Phosphorus Nanosheetsmentioning

confidence: 99%

Recent advances in engineered nanomaterials for acute kidney injury theranostics

Wang

Zhang

et al. 2020

Nano Res.

View full text Add to dashboard Cite

Acute kidney injury (AKI), has become the focus of increasing attention due to its high risk of death. The early diagnosis and treatment of AKI significantly reduce the risk of renal tissue damage and kidney dysfunction. However, the efficient early diagnosis and treatment approach for AKI remains a challenge. AKI screening via precise nanomaterial theranostics is a new alternative approach. This study summarizes the recent advances in functional nanomaterials in the early detection and treatment of AKI. The challenges and problems in the use of nanomaterials for AKI in clinical applications are also discussed. It is anticipated that highlighting these new advances will lay the foundation for further translational research on the promising application of nanomaterials for AKI.

show abstract

“…Geng et al have further demonstrated that BPs tent to accumulate in tumor cells but not the normal cells mainly because of the puissant energy‐dependent endocytosis and BPs suppress tumor growth by apoptosis‐ and autophagy‐mediated cell death (Figure 2C). 44 In vivo tumor imaging has been carried out with near‐infrared fluorescent Cy5.5‐labeled BPs, and results show that BPs aggregate in the liver tumor at 6 h postinjection but degrade gradually in 48 h (Figure 2D). An explanation of the different cytotoxicity may be that higher energy metabolizing rates, more prominent cellular uptake of BP nanosheets, and faster intracellular degradation occur in cancer cells compared to normal cells.…”

Section: Bp Applications In Cancer Therapymentioning

confidence: 99%

“…(B) Reproduced with permission 24 ; Copyright 2019, Proceedings of the National Academy of Sciences of the United States of America. (C‐D) Reproduced with permission 44 Copyright 2020, Ivyspring International Publisher…”

Section: Bp Applications In Cancer Therapymentioning

confidence: 99%

Black phosphorus: Versatile two‐dimensional materials in cancer therapies

Ding

Chu

et al. 2020

VIEW

Self Cite

View full text Add to dashboard Cite

Black phosphorus (BP) constitutes a new class of two‐dimensional materials with multiple biomedical functionalities and applications. Possessed with outstanding advantages of large surface area, intrinsic photoacoustic properties, excellent biocompatibility, and selective toxicity to tumor cells, BP is becoming an ideal candidate in multifunctional cancer theranostics including photothermal therapy, photodynamic therapy, drug delivery, and bioactive phosphotherapy. This minireview summarizes recent progress pertaining to theranostic applications of BP nanosheets and black phosphorus quantum dots and discusses the prospects in advanced theranostics.

show abstract

Bioactive phospho-therapy with black phosphorus for in vivo tumor suppression

Cited by 36 publications

References 49 publications

Photothermal and Enhanced Photocatalytic Therapies Conduce to Synergistic Anticancer Phototherapy with Biodegradable Titanium Diselenide Nanosheets

Photothermal and Enhanced Photocatalytic Therapies Conduce to Synergistic Anticancer Phototherapy with Biodegradable Titanium Diselenide Nanosheets

Recent advances in engineered nanomaterials for acute kidney injury theranostics

Black phosphorus: Versatile two‐dimensional materials in cancer therapies

Contact Info

Product

Resources

About