Bioactive Polyesters in Marine and Plant Endophytic Fungi

Sultan, Sadia

doi:10.5772/47739

Cited by 1 publication

(1 citation statement)

References 28 publications

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“…[ 10 ] and Hansfordia sinuosae [ 11 ]. These polyketides are produced as linear or macrocyclic structures with different patterns of subunit assembly and potential biological activities, such as antimalarial, antifungal, antibacterial and anticancer [ 12 , 13 ]. In particular, macrocyclic polyesters are more bioactive than their opened-structure counterparts because cyclic compounds retain rigidity and do not lose entropy upon interacting with their targeted enzymes [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Putative Biosynthesis of Talarodioxadione & Talarooxime from Talaromyces stipitatus

Fahad

2022

Molecules

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Polyesters containing 2,4-dihydroxy-6-(2-hydroxypropyl)benzoate and 3-hydroxybutyrate moieties have been isolated from many fungal species. Talaromyces stipitatus was previously reported to produce a similar polyester, talapolyester G. The complete genome sequence and the development of bioinformatics tools have enabled the discovery of the biosynthetic potential of this microorganism. Here, a putative biosynthetic gene cluster (BGC) of the polyesters encoding a highly reducing polyketide synthase (HR-PKS) and nonreducing polyketide synthase (NR-PKS), a cytochrome P450 and a regulator, was identified. Although talapolyester G does not require an oxidative step for its biosynthesis, further investigation into the secondary metabolite production of T. stipitatus resulted in isolating two new metabolites called talarodioxadione and talarooxime, in addition to three known compounds, namely 6-hydroxymellein, 15G256α and transtorine that have never been reported from this organism. Interestingly, the biosynthesis of the cyclic polyester 15G256α requires hydroxylation of an inactive methyl group and thus could be a product of the identified gene cluster. The two compounds, talarooxime and transtorine, are probably the catabolic metabolites of tryptophan through the kynurenine pathway. Tryptophan metabolism exists in almost all organisms and has been of interest to many researchers. The biosynthesis of the new oxime is proposed to involve two subsequent N-hydroxylation of 2-aminoacetophenone.

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Section: Introductionmentioning

confidence: 99%

Putative Biosynthesis of Talarodioxadione & Talarooxime from Talaromyces stipitatus

Fahad

2022

Molecules

View full text Add to dashboard Cite

show abstract

Bioactive Polyesters in Marine and Plant Endophytic Fungi

Cited by 1 publication

References 28 publications

Putative Biosynthesis of Talarodioxadione & Talarooxime from Talaromyces stipitatus

Putative Biosynthesis of Talarodioxadione & Talarooxime from Talaromyces stipitatus

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