Bioactive Polymeric Metallosomes Self-Assembled through Block Copolymer–Metal Complexation

Abstract

Spontaneous formation of polymeric metallosomes with uniform size (~100 nm) was found to occur in aqueous medium through the reaction of an anticancer agent, (1,2-diaminocyclohexane)platinum(II) (DACHPt), with a Y-shaped block copolymer of ω-cholesteroyl-poly(L-glutamic acid) and two-armed poly(ethylene glycol) (PEGasus-PLGA-Chole). Circular dichroism spectrum measurements revealed that the PLGA segment forms an α-helix structure within the metallosomes, suggesting that secondary-structure formation of metallocomplexed PLGA segment may drive the self-assembly of the system into vesicular structure. These metallosomes can encapsulate water-soluble fluorescent macromolecules into their inner aqueous phase and eventually deliver them selectively into tumor tissues in mice, owing to the prolonged blood circulation. Accordingly, fluorescent imaging of the tumor was successfully demonstrated along with an appreciable antitumor activity by DACHPt moieties retained in the vesicular wall of the metallosomes, indicating the potential of metallosomes as multifunctional drug carriers.

Poly-cyclodextrin and poly-paclitaxel nano-assembly for anticancer therapy

“…D rug-loaded polymeric nanocarriers are of immense interest as anticancer drug-delivery systems due to their ability to extravasate within the tumours via the enhanced permeation and retention (EPR) effect [1][2][3][4] . Polymeric delivery systems can also enhance the aqueous solubility and modify the pharmacokinetics and biodistribution of lipophilic drugs [5][6][7][8][9][10][11][12] .…”

Fabrication of Graphene-isolated-Au-nanocrystal Nanostructures for Multimodal Cell Imaging and Photothermal-enhanced Chemotherapy

“…Accordingly, such materials as quantum dots12, gold nanoparticles345, carbon nanotubes67, graphene89, and polymersomes10 have all been investigated and have shown promise in a wide range of biomedical applications11. Simultaneous diagnostics, therapeutics, and monitoring of response to treatment are realized with such multifunctional nanomaterials and nanostructures, which also offer the potential of both reducing common chemotherapy- or radiation-associated side effects and increasing the effectiveness of therapy121314.…”

Near infrared light-actuated gold nanorods with cisplatin–polypeptide wrapping for targeted therapy of triple negative breast cancer

“…Cisplatin, a cytotoxic drug with wide anticancer spectrum was then loaded on GNR-PGA via Please do not adjust margins Please do not adjust margins formation of coordination bonds between the carboxylic groups of PGA and the platinum atom of cisplatin (Scheme 1b). 26,27 A cisplatin to Au loading ratio of 4.8 wt% and a drug loading efficiency of 13.0% were achieved when GNR@Pt nanoparticles were prepared at a cisplatin to Au feeding ratio of 0.37 as determined using inductively coupled plasma mass spectrometry (ICP-MS) measurement ( Figure 1c). The LSPR absorbance of GNR-PGA decreased slightly upon cisplatin loading, which might be caused by sample loss during centrifugation ( Figure 1a & SI 8).…”