Bioactive polymers: A comprehensive review on bone grafting biomaterials

Pourhajrezaei, Sana; Abbas, Zahid; Khalili, Mohammad Amin; Madineh, Hossein; Jooya, Hossein; Babaeizad, Ali; Gross, Jeffrey D.; Samadi, Ali

doi:10.1016/j.ijbiomac.2024.134615

International Journal of Biological Macromolecules

2024

DOI: 10.1016/j.ijbiomac.2024.134615

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Bioactive polymers: A comprehensive review on bone grafting biomaterials

Sana Pourhajrezaei,

Zahid Abbas,

Mohammad Amin Khalili

et al.

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Cited by 4 publications

References 205 publications

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Immunomodulatory and osteogenic effects of chitosan-based injectable hydrogel with geniposide-loaded mesoporous bioactive glass

Deng,

Yao,

Zhao

et al. 2025

International Journal of Biological Macromolecules

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Immunomodulatory and osteogenic effects of chitosan-based injectable hydrogel with geniposide-loaded mesoporous bioactive glass

Deng,

Yao,

Zhao

et al. 2025

International Journal of Biological Macromolecules

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Biomimetic Natural Biomaterial Nanocomposite Scaffolds: A Rising Prospect for Bone Replacement

Zaczek-Moczydłowska,

Joszko,

Kavoosi

et al. 2024

IJMS

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Biomimetic natural biomaterial (BNBM) nanocomposite scaffolds for bone replacement can reduce the rate of implant failure and the associated risks of post-surgical complications for patients. Traditional bone implants, like allografts, and autografts, have limitations, such as donor site morbidity and potential patient inflammation. Over two million bone transplant procedures are performed yearly, and success varies depending on the material used. This emphasizes the importance of developing new biomaterials for bone replacement. Innovative BNBM nanocomposites for modern bone fabrication can promote the colonization of the desired cellular components and provide the necessary mechanical properties. Recent studies have highlighted the advantages of BNBM nanocomposites for bone replacement; therefore, this review focuses on the application of cellulose, chitosan, alginates, collagen, hyaluronic acid, and synthetic polymers enhanced with nanoparticles for the fabrication of nanocomposite scaffolds used in bone regeneration and replacement. This work outlines the most up-to-date overview and perspectives of selected promising BNBM nanocomposites for bone replacement that could be used for scaffold fabrication and replace other biomorphic materials such as metallics, ceramics, and synthetic polymers in the future. In summary, the concluding remarks highlight the advantages and disadvantages of BNBM nanocomposites, prospects, and future directions for bone tissue regeneration and replacement.

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An Up-to-Date Review of Materials Science Advances in Bone Grafting for Oral and Maxillofacial Pathology

Nicolae,

Pîrvulescu,

Niculescu

et al. 2024

Materials

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Bone grafting in oral and maxillofacial surgery has evolved significantly due to developments in materials science, offering innovative alternatives for the repair of bone defects. A few grafts are currently used in clinical settings, including autografts, xenografts, and allografts. However, despite their benefits, they have some challenges, such as limited availability, the possibility of disease transmission, and lack of personalization for the defect. Synthetic bone grafts have gained attention since they have the potential to overcome these limitations. Moreover, new technologies like nanotechnology, 3D printing, and 3D bioprinting have allowed the incorporation of molecules or substances within grafts to aid in bone repair. The addition of different moieties, such as growth factors, stem cells, and nanomaterials, has been reported to help mimic the natural bone healing process more closely, promoting faster and more complete regeneration. In this regard, this review explores the currently available bone grafts, the possibility of incorporating substances and molecules into their composition to accelerate and improve bone regeneration, and advanced graft manufacturing techniques. Furthermore, the presented current clinical applications and success stories for novel bone grafts emphasize the future potential of synthetic grafts and biomaterial innovations in improving patient outcomes in oral and maxillofacial surgery.

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Bioactive polymers: A comprehensive review on bone grafting biomaterials

Cited by 4 publications

References 205 publications

Immunomodulatory and osteogenic effects of chitosan-based injectable hydrogel with geniposide-loaded mesoporous bioactive glass

Immunomodulatory and osteogenic effects of chitosan-based injectable hydrogel with geniposide-loaded mesoporous bioactive glass

Biomimetic Natural Biomaterial Nanocomposite Scaffolds: A Rising Prospect for Bone Replacement

An Up-to-Date Review of Materials Science Advances in Bone Grafting for Oral and Maxillofacial Pathology

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