Bioactive polyphenols from Ranunculus macrophyllus Desf. Roots: Quantification, identification and antioxidant activity

Deghima, Amirouche; Righi, Nadjat; Rosales-Conrado, Noelia; León-González, María Eugenia; Gómez-Mejía, Esther; Madrid, Yolanda; Baali, Faiza; Bedjou, Fatiha

doi:10.1016/j.sajb.2020.03.036

Cited by 20 publications

(19 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Overwhelming evidence has demonstrated that many factors, involving the genetic inheritance, extraction method and the solvent system concept, may affect the extraction yield and influence the diversity and nature of chemical contents between Ruta plants [ 12 , 24 , 40 ]. Indeed, the chemical proprieties of different secondary metabolite classes significantly influence their solubility and consequently their extractability yields [ 7 ]. From these results, we can suggest that hydro-alcoholic solvent was mostly the suitable system used to extract the maximum of recovery vegetal secondary metabolites with high and middle polarity, in particular, the diverse phenolic classes which are well known to possess various pharmacological proprieties such as antioxidant, anti-inflammatory, antiulcerogenic and neuro-protective activities.…”

Section: Discussionmentioning

confidence: 99%

“…In fact, the reducing power capacities that possess R. tuberculata extracts are probably linked to their polyphenols content, which act similarly as redactors via their electron donating ability. Relevantly, it has been documented that the main antioxidant compounds responsible for the reducing power of plant extracts are the small phenols, based on their power to provide more atoms and, consequently, to effectively reduce the ferric and cupper ions [ 7 , 46 ]. Therefore, it could be stated that the antioxidant potential of polyphenols is strongly related to their redox proprieties, where they act as free radical scavengers through hydrogen and electron transfer mechanisms, as metal ions’ binding agents and as modulators of the endogenous antioxidant systems [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, the use of synthetic AChEI drugs is undesirably perceived by consumers due to their side effects, such as hypatotoxicity, gastro-intestinal disturbances, vomiting and diarrhea [ 1 ]. Furthermore, non-steroidal anti-inflammatory drugs (NSAIDs) are given as complementary treatment, but may present some drawbacks when used excessively during a long period of time due to the acquisition of drug resistance phenomenon, which underlines the urgent situation to develop more effective natural anti-inflammatory drugs with fewer undesirable effects [ 6 , 7 ]. Recently, there is a growing interest in studying medicinal plants in order to understand their full pharmacological potential along with preventing the development of chronic and degenerative diseases.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Phenolic Characterization Using cLC-DAD Analysis and Evaluation of In Vitro and In Vivo Pharmacological Activities of Ruta tuberculata Forssk

et al. 2022

View full text Add to dashboard Cite

The perennial aromatic plant Ruta tuberculata Forssk (Rutaceae) has been traditionally used by Mediterranean peoples as folk medicine against several types of disease to treat diverse illness. The objective of this work is to evaluate the in vitro and in vivo pharmacological activities of the aqueous (RAE) and methanolic (MeOH) 80% (RME) extracts of Algerian R. tuberculata aerial parts. Antioxidant potential, neuro-protective and anti-arthritic activities were investigated in vitro using six antioxidant approaches and by determining acetyl-cholinesterase and bovine albumin denaturation inhibitory capacities, respectively. Furthermore, in vivo anti-ulcer and anti-inflammatory activities were evaluated on EtOH-induced gastric mucosal damage and carrageenan-induced paw edema models in mice. Moreover, bio-compounds’ contents were also quantified using spectrophotometric and cLC-DAD methods. Both in vivo and in vitro investigations showed remarkable antioxidant activity of Ruta tuberculata Forssk, while methanolic extract (RME) of Ruta tuberculata Forssk exhibited more significant neuro-protective and anti-inflammatory effects. However, the antiulcer activity was more pronounced with RAE of R. tuberculata, which suggests that this plant can be considered as a natural resource of potent bioactive compounds that may act as antioxidant and anti-inflammatory agents, which underlines the importance of incorporating them in therapies in order to treat various diseases linked to oxidative stress, and they may also provide crucial data for the development of new anticholinesterase drugs to improve neurodegenerative diseases, such as Alzheimer’s.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Phenolic Characterization Using cLC-DAD Analysis and Evaluation of In Vitro and In Vivo Pharmacological Activities of Ruta tuberculata Forssk

et al. 2022

View full text Add to dashboard Cite

show abstract

“…pred . (14) Expressed as a % of x pred , %. At the 95% confidence level, the 2-tailed Student t value for 5 degrees of freedom is 2.571.…”

Section: Temperaturementioning

confidence: 99%

“…Cosmetic companies must use ingredients registered in database created by the European Commission (CosIng) to market their cosmetic products in the European Union [13]. Many countries follow this regulation since their objectives are to export cosmetic products to Europe and to sustain the efficacy of cosmetic ingredients and products [14]. The market value of medicinal plants market is estimated expected to reach about 5 trillion USDby 2050 [15].…”

Section: Introductionmentioning

confidence: 99%

Determination of Total Phenolic Content From Plant Extracts Used in Cosmetic Purpose

Dobrinaș

Soceanu

2021

J. Sci. Arts

View full text Add to dashboard Cite

Spectrometric analysis belongs to a group of measurement methods used for their simplicity and large selectivity to solve various problems of analytes. The total phenolic content of different plant extracts used for cosmetic purpose was determined by a slightly modified version of traditionally Folin-Ciocalteau method. The objective of this work was the validation of UV-Vis spectrometric method, investigation of uncertainty sources when measuring gallic acid concentration and evaluation of the calibration equation effect on measurement uncertainty of UV– Vis spectrophotometer. Validation was performed by studying analytical curve linearity (R2=0.9995) and range (37.5 – 225 mg L-1), estimated limit of detection (LOD, 0.11mg L-1) and limit of quantification (LOQ, 0.37 mg L-1), precision (%RSD, 0.14 – 1.34), recoveries (83-110%) and stability (%RSD, 0.8 – 2.83). To obtain more representative values for precision, recoveries and stability simultaneous replicates at different times, on different matrices including plant (marigold, chamomile and lavender) were performed during the study period. The validated method was successfully applied to determine TPC in marigold extracts. For chamomile and lavender extracts, the spectrometric method presented only acceptable precision, among all the performance parameters studied. The sources of the gallic acid concentration measurement uncertainty include purity, volume of flasks, mass and the calibration equation. The results indicated that the uncertainty components from purity were the smallest. An important source of the uncertainty was the mass.The volumes of the volumetric flasks had only modest effect on the uncertainty. The contribution of calibration equation is the greatest from all sources.

show abstract

Polyphenolic Profile and In vitro, In Silico Study of Stem Extracts from J. Maritimus (Juncaceae) Harvested from Eastern Algeria as Potential Anti‐Inflammatory and Antioxidant Agents

Zeroual,

Daoud,

Gaouaoui

et al. 2024

Chemistry & Biodiversity

View full text Add to dashboard Cite

The extremophilic species Juncus maritimus known for its medicinal virtues was collected in the Biskra region with the aim of its valorization. The volume size of polyphenols, flavonoids and condensed tannins was carried out by Folin‐Ciocalteu methods, aluminum trichloride and vanillin respectively. Polyphenols volume is 127.73±0.20 μg EAG/mg ES, flavonoids 16.42±0.42 μg EQ/mg ES and condensed tannins 10.10±0.35 μg EC/mg ES. The result of antioxidant activity tested by employing DPPH and ABTS methods reveal that the ethyl acetate extract had the highest activity in both tests. The result of in vitro anti‐inflammatory activity, by the BSA protein denaturation test, showed that the percentage inhibition of denaturation is proportional to the concentration of the extract. At a concentration of 5 mg/mL, the percentage inhibition of the extract was close to that an anti‐inflammatory drug Diclofenac with 82.03 and 80.23% respectively. Furthermore, molecular docking simulations revealed that Berberine was shown high binding affinity with the COX‐2 and PLA‐2 targets. Indeed, bioisosteric replacement is applied to discover novel analogs of Berberine. Finally, ADME‐Tox prediction demonstrated that this compound and its analogs are without Hepatotoxicity. The results might be selecting that Berberine and its analogs as active compound with anti‐inflammatory and antioxidant activities.

show abstract

Bioactive polyphenols from Ranunculus macrophyllus Desf. Roots: Quantification, identification and antioxidant activity

Cited by 20 publications

References 55 publications

Phenolic Characterization Using cLC-DAD Analysis and Evaluation of In Vitro and In Vivo Pharmacological Activities of Ruta tuberculata Forssk

Phenolic Characterization Using cLC-DAD Analysis and Evaluation of In Vitro and In Vivo Pharmacological Activities of Ruta tuberculata Forssk

Determination of Total Phenolic Content From Plant Extracts Used in Cosmetic Purpose

Polyphenolic Profile and In vitro, In Silico Study of Stem Extracts from J. Maritimus (Juncaceae) Harvested from Eastern Algeria as Potential Anti‐Inflammatory and Antioxidant Agents

Contact Info

Product

Resources

About