Bioactive Products from Fungi

Sánchez, Sergio; Demain, Arnold L.

doi:10.1007/978-3-319-51639-4_3

Cited by 30 publications

(25 citation statements)

References 142 publications

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“…In general, bioactive compounds are found in small quantities in different foods, generally vegetables, fruits and plant-based products (mainly polyphenols, alkaloids, terpenes or saponins) [ 235 ]. However, animal foods, fungi and even marine microbials might provide interesting bioactive compounds that may be potentially used as nutraceuticals [ 236 , 237 , 238 ]. Therefore, there are many bioactive compounds provided by different types of food which may be critical for a proper functioning of the brain, mainly due to their anti-inflammatory and antioxidant properties [ 239 ].…”

Section: Nutraceuticals In Mddmentioning

confidence: 99%

Exploring the Role of Nutraceuticals in Major Depressive Disorder (MDD): Rationale, State of the Art and Future Prospects

et al. 2021

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Major depressive disorder (MDD) is a complex and common disorder, with many factors involved in its onset and development. The clinical management of this condition is frequently based on the use of some pharmacological antidepressant agents, together with psychotherapy and other alternatives in most severe cases. However, an important percentage of depressed patients fail to respond to the use of conventional therapies. This has created the urgency of finding novel approaches to help in the clinical management of those individuals. Nutraceuticals are natural compounds contained in food with proven benefits either in health promotion or disease prevention and therapy. A growing interest and economical sources are being placed in the development and understanding of multiple nutraceutical products. Here, we summarize some of the most relevant nutraceutical agents evaluated in preclinical and clinical models of depression. In addition, we will also explore less frequent but interest nutraceutical products which are starting to be tested, also evaluating future roads to cover in order to maximize the benefits of nutraceuticals in MDD.

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Section: Nutraceuticals In Mddmentioning

confidence: 99%

Exploring the Role of Nutraceuticals in Major Depressive Disorder (MDD): Rationale, State of the Art and Future Prospects

et al. 2021

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“…Other enzyme inhibitors are suitable to control arthritis, pancreatitis, cancer and AIDS, Alzheimer's disease etc. Examples of products originating from soil microbiota are paim from Streptomyces corchorushii , lipstatin from Streptomyces toxytricini , and antipain from Streptomyces yokosukaensis [294–296]. Statins are mentioned below (hypocholesterolemic drugs).Immunosuppressants: these medicinal products are used to suppress the immune reaction after transplantation of organs such as heart, liver and kidney.…”

Section: Medicinal Resourcesmentioning

confidence: 99%

The role of soils in provision of genetic, medicinal and biochemical resources

Thiele‐Bruhn

2021

Phil. Trans. R. Soc. B

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Intact, ‘healthy’ soils provide indispensable ecosystem services that largely depend on the biotic activity. Soil health is connected with human health, yet, knowledge of the underlying soil functioning remains incomplete. This review highlights selected services, i.e. (i) soil as a genetic resource and hotspot of biodiversity, forming the basis for providing (ii) biochemical resources and (iii) medicinal services and goods. Soils harbour an unrivalled biodiversity of organisms, especially microorganisms. Some of the abilities of autochthonous microorganisms and their relevant enzymes serve (i) to improve natural soil functions and in particular plant growth, e.g. through beneficial plant growth-promoting, symbiotic and mycorrhizal microorganisms, (ii) to act as biopesticides, (iii) to facilitate biodegradation of pollutants for soil bioremediation and (iv) to yield enzymes or chemicals for industrial use. Soils also exert direct effects on human health. Contact with soil enriches the human microbiome, affords protection against allergies and promotes emotional well-being. Medicinally relevant are soil substrates such as loams, clays and various minerals with curative effects as well as pharmaceutically active organic chemicals like antibiotics that are formed by soil microorganisms. By contrast, irritating minerals, soil dust inhalation and misguided soil ingestion may adversely affect humans. This article is part of the theme issue ‘The role of soils in delivering Nature’s Contributions to People.

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“…Today, the view on fungi has altered to take into account their advantageous effects, which have become apparent in biotechnological and industrial fields, as well as the production of structurally unique and life-saving metabolites [2][3][4][5]. In the past decades, the number of bioactive metabolites isolated from fungi has been rapidly increased due to their wide diversity of ecological and environmental niches across the globe, including marine, terrestrial, and water environments where they function as pathogens, symbionts, and saprobes [6,7]. Fungi-derived metabolites have made remarkable contributions to the process of drug discovery [8][9][10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

“…Fungi-derived metabolites have made remarkable contributions to the process of drug discovery [8][9][10][11][12][13][14][15][16]. They have been used as antibiotics, herbicides, pesticides, anti-infectives, immuno-suppressants, and anticancer agents [6,7,17]. Depsides are simple polyketides that are formed by the condensation of two or more hydroxybenzoic acid moieties via ester linkage; the COOH group of one molecule is esterified with a phenolic OH group of the second molecule.…”

Section: Introductionmentioning

confidence: 99%

Fungal Depsides—Naturally Inspiring Molecules: Biosynthesis, Structural Characterization, and Biological Activities

et al. 2021

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Fungi represent a huge reservoir of structurally diverse bio-metabolites. Although there has been a marked increase in the number of isolated fungal metabolites over the past years, many hidden metabolites still need to be discovered. Depsides are a group of polyketides consisting of two or more ester-linked hydroxybenzoic acid moieties. They possess valuable bioactive properties, such as anticancer, antidiabetic, antibacterial, antiviral, anti-inflammatory, antifungal, antifouling, and antioxidant qualities, as well as various human enzyme-inhibitory activities. This review provides an overview of the reported data on fungal depsides, including their sources, biosynthesis, physical and spectral data, and bioactivities in the period from 1975 to 2020. Overall, 110 metabolites and more than 122 references are confirmed. This is the first review of these multi-faceted metabolites from fungi.

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Bioactive Products from Fungi

Cited by 30 publications

References 142 publications

Exploring the Role of Nutraceuticals in Major Depressive Disorder (MDD): Rationale, State of the Art and Future Prospects

Exploring the Role of Nutraceuticals in Major Depressive Disorder (MDD): Rationale, State of the Art and Future Prospects

The role of soils in provision of genetic, medicinal and biochemical resources

Fungal Depsides—Naturally Inspiring Molecules: Biosynthesis, Structural Characterization, and Biological Activities

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