Bioactive sphingolipids as emerging targets for signal transduction in cancer development

Jia, Wentao; Yuan, Jiaying; Zhang, Jinbo; Li, Shu; Lin, Wanfu; Cheng, Binbin

doi:10.1016/j.bbcan.2024.189176

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

2024

DOI: 10.1016/j.bbcan.2024.189176

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Bioactive sphingolipids as emerging targets for signal transduction in cancer development

Wentao Jia,

Jiaying Yuan,

Jinbo Zhang

et al.

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Cited by 3 publications

References 583 publications

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Naunyn-Schmiedeberg's Arch Pharmacol

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Unleashing the potential of Genistein and its derivatives as effective therapeutic agents for breast cancer treatment

Qaed,

Liu,

Almoiliqy

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Theoretical framework and emerging challenges of lipid metabolism in cancer

Gu,

Wang,

et al. 2025

Seminars in Cancer Biology

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The role of ACER2 in intestinal sphingolipid metabolism and gastrointestinal cancers

Liu,

Zhou,

Jiang

et al. 2024

Front. Immunol.

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Sphingolipids, particularly sphingosine-1-phosphate (S1P), are bioactive lipids involved in regulating cellular processes such as proliferation, apoptosis, inflammation, and tumor progression. Alkaline ceramidase 2 (ACER2) plays a critical role in sphingolipid metabolism by catalyzing the hydrolysis of ceramide to sphingosine, which is subsequently converted to S1P. Dysregulation of ACER2 has been implicated in various gastrointestinal cancers, including colorectal cancer, gastric cancer, and hepatocellular carcinoma. ACER2-mediated sphingolipid signaling, particularly through the SphK/S1P pathway, influences cancer development by modulating immune responses, inflammation, and the balance between cell survival and death. This review examines the physiological functions of ACER2, and its role in sphingolipid metabolism, and its contribution to the pathogenesis of gastrointestinal cancers. Understanding the mechanisms by which ACER2 regulates tumor progression and immune modulation may open new avenues for targeted therapies in gastrointestinal malignancies.

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Bioactive sphingolipids as emerging targets for signal transduction in cancer development

Cited by 3 publications

References 583 publications

Unleashing the potential of Genistein and its derivatives as effective therapeutic agents for breast cancer treatment

Unleashing the potential of Genistein and its derivatives as effective therapeutic agents for breast cancer treatment

Theoretical framework and emerging challenges of lipid metabolism in cancer

The role of ACER2 in intestinal sphingolipid metabolism and gastrointestinal cancers

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