Bioactive toothpastes in dentin hypersensitivity treatment: A systematic review

Freitas, Samantha Ariadne Alves de; Oliveira, Neurinéia Margarida Alves de; Geus, Juliana Larocca de; Souza, Soraia de Fátima Carvalho; Pereira, Adriana de Fátima Vasconcelos; Bauer, José

doi:10.1016/j.sdentj.2021.04.004

Cited by 19 publications

(13 citation statements)

References 28 publications

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“…The BAG mechanism in decreasing TS might be explained due to its remineralization effect and the deposition of the hydroxycarbonate apatite (HCA) layer which has a role in occluding dentinal tubules [ 45 ].This is in agreement with a previous clinical study where the application of BAG decreased significantly the TS associated with in-office bleaching using 35% hydrogen peroxide (HP) gel [ 46 ]. A beneficial effect for BAG pastes (2.5–7.5%) in reducing TS was documented in a previous systematic review [ 44 ]. The evaluation of the possible impact of BAG pastes on TS related to at-home tooth bleaching with 20% CP has not been reported in the literature.…”

Section: Discussionmentioning

confidence: 85%

“…Different materials and pastes have been introduced to reduce TS during teeth bleaching, [ 7 , 21 , 24 , 38 – 43 ]. These agents may reduce sensory nerve activity such as potassium salts or block dentine tubules as fluoride, arginine, CPP-ACP and BAG [ 39 , 44 ]. The results of the present study demonstrated that the use of BAG paste significantly reduced TS and therefore, the first null hypothesis was rejected.…”

Section: Discussionmentioning

confidence: 99%

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Effect of bioactive glass paste on efficacy and post-operative sensitivity associated with at-home bleaching using 20% carbamide peroxide: a randomized controlled clinical trial

Bizreh

Milly

2022

Eur J Med Res

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Background The aim of this study was to evaluate the effect of bioactive glass (BAG) 45S5 paste on colour change and tooth sensitivity (TS) when used in combination with 20% carbamide peroxide (CP) during at-home vital tooth bleaching. Methods Twenty-four patients were selected and assigned into two experimental groups (n = 12) in a double-blind study design. Each patient received 20% CP followed by the application of either BAG paste or non-active placebo paste. The shade evaluation was performed using a digital spectrophotometer based on the CIE L*a*b* colour space system at different time points and the overall colour changes ΔE were calculated. TS was evaluated using visual analogue scale (VAS). The values of ΔE and TS were statistically analysed using paired t-test. The level of statistical significance was established at p = 0.05. Results The overall colour changes (ΔE) between baseline and each time point showed no significant differences between BAG and placebo groups (p > 0.05). The use of BAG paste significantly decreased TS reported by the participants. Conclusions The association of BAG paste with at-home bleaching treatment presents a promising method as it decreased TS and did not deteriorate bleaching efficacy. Trial registration This study was approved and registered in the Australian New Zealand Clinical Trials Registry (ANZCTR) under Registration number: ACTRN12621001334897.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Effect of bioactive glass paste on efficacy and post-operative sensitivity associated with at-home bleaching using 20% carbamide peroxide: a randomized controlled clinical trial

Bizreh

Milly

2022

Eur J Med Res

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“…Desensitizing dentifrices act by depositing minerals on the dentin surface and inside the dentinal tubules, obliterating them [1,2,8,24]. However, how this affects the dental surface characteristics, such as dentin wettability by adhesives, has not been elucidated yet.…”

Section: Discussionmentioning

confidence: 99%

“…In order to treat dentin hypersensitivity, a very common condition, desensitizing toothpastes can be used [1][2][3][4][5][6][7][8]. However, as they act by depositing minerals, such as calcium and silicon, inside the dentinal tubules and on the dentin surface, they can change the morphology and composition of the dentin and interfere with the wettability of the substrate, altering the dispersion of dentin adhesives used in dental restorations [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Effect of desensitizing dentifrices on eroded dentin wettability

et al. 2022

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Objective:To analyze the wettability on the surface of eroded dentin in teeth submitted to abrasive wear with desensitizing dentifrices. Material and Methods: Bovine dentin specimens were polished and immersed in 10 mL of citric acid (pH=3.2) for 2 h. The eroded specimens were submitted to mechanic brushing according to the 4 dentifrices adopted: Colgate Total (control); Colgate Sensitive Pro-Relief; Sensodyne Repair & Protect; or Sensodyne Rapid Relief. Afterwards, it was conditioned in 37% aqueous phosphoric acid solution. Wettability of 80 specimens (n=10) brushed for 7 or 21 days was evaluated by measuring the contact angle between the dentin surface and a drop of the adhesive Single Bond Universal® (3M) with a goniometer. Changes in the surface morphology of 12 specimens (n = 3) brushed for 21 days were followed by confocal laser scanning microscopy (CLSM). Data were analyzed by two-way ANOVA and Tukey test (p > 0.05). Results: Groups treated with desensitizing dentifrices did not differ significantly (p ≤ 0.05). Surface treatment and abrasive wear did not interact significantly (p ≤ 0.05). Brushing along 7 days gave the smallest contact angle value (p ≥ 0.05). CLSM images showed morphological changes for all the groups. Conclusion: The desensitizing dentifrices did not interfere in eroded dentin wettability after brushing along 7 or 21 days. Brushing with any of the dentifrices along 21 days promoted open dentinal tubules.

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“…[ 144 ] A very recent systematic review on the use of bioactive DAs in toothpastes has concluded that these compounds at low concentrations (2.5%–7.5%) can be used as the treatment of DH both at-home and in-office. [ 145 ] Major mechanisms of action of various desensitizing toothpastes are summarized in Table 3 . [ 125 ]…”

Section: Classification Of Desensitizing Agentsmentioning

confidence: 99%

ISP Good Clinical Practice Recommendations for the management of Dentin Hypersensitivity

Grover

Kumar

Jain

et al. 2022

Journal of Indian Society of Periodontology

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Dentin hypersensitivity (DH) is a rising concern in clinical dentistry that causes pain and discomfort and negatively affects the quality of life of patients. Indian Society of Periodontology conducted a nationwide survey, involving 3000 dentists in December 2020, which revealed significant knowledge gaps regarding DH, viz., under-diagnosis, incorrect differential diagnosis, and treatment strategies/recommendations for the management of DH patients in daily clinical practice. The current paper has been envisioned and conceptualized to update the practicing Indian dentists regarding the so-called enigma of dentistry “Dentin Hypersensitivity,” based on the best available contemporary evidence. An expert panel was constituted comprising 30 subject experts from across the country, which after extensive literature review and group discussions formulated these recommendations. The panel advocated routine screening of all dentate patients for exposed dentin areas and DH to avoid under-diagnosis of the condition and suggested an early preventive management. Consensus guidelines/recommendations for the use of desensitizing agents (DAs) at home, including the use of herbal agents, are also provided within the backdrop of the Indian context. The guidelines recommend that active management of DH shall be accomplished by a combination of at home and in-office therapies, starting with the simplest and cost-effective home use of desensitizing toothpastes. A diagnostic decision tree and a flowchart for application in daily practice are designed to manage the patients suffering from DH or presenting with exposed dentin areas in dentition. Various treatment methods to manage DH have been discussed in the paper, including the insights from previously published treatment guidelines. Further, a novel system of classification of DH patients based on specific case definitions has been developed for the first time. Explicit charts regarding the available treatment options and the chronology of institution of the agent, for the management in different case categories of DH, have been provided for quick reference. The management strategy takes into account a decision algorithm based on hierarchy of complexity of treatment options and intends to improve the quality of life of the patient by long-term maintenance with an innovatively defined triple C's or 3Cs approach.

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Bioactive toothpastes in dentin hypersensitivity treatment: A systematic review

Cited by 19 publications

References 28 publications

Effect of bioactive glass paste on efficacy and post-operative sensitivity associated with at-home bleaching using 20% carbamide peroxide: a randomized controlled clinical trial

Effect of bioactive glass paste on efficacy and post-operative sensitivity associated with at-home bleaching using 20% carbamide peroxide: a randomized controlled clinical trial

Effect of desensitizing dentifrices on eroded dentin wettability

ISP Good Clinical Practice Recommendations for the management of Dentin Hypersensitivity

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