Bioactive triterpenoids and water-soluble melanin from Inonotus obliquus (Chaga) with immunomodulatory activity

Wold, Christian Winther; Gerwick, William H.; Wangensteen, Helle; Inngjerdingen, Kari Tvete

doi:10.1016/j.jff.2020.104025

Cited by 46 publications

(57 citation statements)

References 38 publications

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“…Recent studies also relevant that echinacoside and caffeic acid derivative have weak anti-bacterial and antiviral effects and are protectants against reactive oxygen species 20,39 . The antioxidant activity could be ascribed to the polyphenolic components 13 , such as flavonoids 34 , phenolic acids 35 or phenolic diterpenes 9 .…”

Section: Discussionmentioning

confidence: 99%

“…The analysis of total flavonoid content in rhizomata cum radicibus extracts was performed by colorimetric method 35 . Briefly, 30 μL of the extract was added to 150 μL of sodium nitrate (5% W/V) followed by the addition of 3 mL of aluminum chloride hexahydrate (10% W/V) and incubated for 5 min 35 . The 1 mL of NaOH (1.0 M) was added to the mixture and diluted to the mark with distilled water.…”

Section: Materials and Methods Experimental Backgroundmentioning

confidence: 99%

“…After incubation at room temperature in dark place for 30 min, the absorbance of the solution was measured at 415 nm by spectrophotometer. For the quantification of TFC, the quercetin (QE) was used as an external standard 35 where A control and A sample are the absorbance of the control and the sample respectively.…”

Section: Materials and Methods Experimental Backgroundmentioning

confidence: 99%

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Improving growth properties and phytochemical compounds of Echinacea purpurea (L.) medicinal plant using novel nitrogen slow release fertilizer under greenhouse conditions

Ahmadi

Samadi

Rahimi

2020

Sci Rep

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Medicinal plant production is most important than other agricultural plants due to their phytochemical compounds effects on human health. Paying attention to plant nutrition requirement is so important. In order to assess the effect of nitrate (NO 3 −) dosage supplies from two types of fertilizers on growth and phytochemical properties of Echinacea purpurea rhizomata cum radicibus, an experiment with completely simple design was carried out under greenhouse conditions. two types of fertilizers (new invented nitrogen (N) slow release fertilizer and urea chemical fertilizer) at three dosages (50, 100, and 150 mM) were applied. Plant growth parameters and total phenolic (TPC), total flavonoids (TFC), polysaccarides content, essential oil content, caffeic acid derivatives, and anti-radical scavenging activities of E. purpurea were assessed. The results showed the significant (p ≤ 0.01) differences among treatments, both in growth and phytochemical properties. Using of n slow release, especially in 150 mM dosage, significantly increased all the plant growth and phytochemical properties. The dried E. purpurea rhizomata cum radicibus contained more caftaric acid (max 12.56 mg g −1 DW) and chicoric acid (max 7.56 mg g −1 DW) than other derivatives. Despite the impact of heavy metals on yield and growth of E. purpurea, the concentration of all heavy metals and micronutrients (boron (B), cadmium (cd), copper (cu), iron (fe), manganese (Mn), molybdenum (Mo), nickel (ni), lead (pb), and zinc (Zn)) in studied soil and fertilizer samples was less than United States environmental protection Agency (USepA) limits of contamination. Based on the results, using of n slow release fertilizers can improve phytochemical properties of the plant due to its polymeric structure and can be a suitable substitution of chemical fertilizers, especially in medicinal plants growth. Many of researchers are pay attention to herbal and medicinal plants as natural remedies due to their bioactive compounds recently 1,2. Echinacea purpurea (L.) Moench is one of the most important medical plants of Asteraceae family with various pharmacological effects 3. The major three species of Echinacea are known as Echinacea angustifolia, Echinacea purpurea, and Echinacea pallida. E. purpurea is native to much of the United States and its morphological properties are also known as purple coneflower with orange and cone-shaped flowering head that change to purple, rose, or white petals during June to September 4. It has a narrow leaves and three feet height stem with dark, thick and pungent rhizomata cum radicibus 5. In the environment, E. purpurea grows randomically along water canals with low densities for affective harvest for commercial purposes 6. Comparing of other Echinacea species, E. purpurea is the most able species to adjust to new conditions. It is resistance to heat or cold weather conditions, easy to grow, and flaunt high efficiency 7,8. Numerous scientific

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Section: Discussionmentioning

confidence: 99%

Section: Materials and Methods Experimental Backgroundmentioning

confidence: 99%

Section: Materials and Methods Experimental Backgroundmentioning

confidence: 99%

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Improving growth properties and phytochemical compounds of Echinacea purpurea (L.) medicinal plant using novel nitrogen slow release fertilizer under greenhouse conditions

Ahmadi

Samadi

Rahimi

2020

Sci Rep

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“…Myriceric acid A 17Hexane extract of Morella cerifera (L.) Small (Myrica cerifera) bark [18] Antitumor activity [58] NCI-H460 cell line: EC50 = 2.8 ± 0.4 µM (Podophyllotoxin: EC50 = 22 ± 6 µM). HT29-MTX cell line: EC50 = 1.6 ± 0.4 µM (Podophyllotoxin: EC50 = 24 ± 3 µM).…”

Section: Origin Biological Activitiesmentioning

confidence: 99%

“…The authors found that the effect of 16 in osteosarcoma cell lines is through the induction of apoptosis and autophagy to suppress cell viability, as well as by the inhibition of mTOR signaling. Betulin ( 16 ) is also very active against the NCi-H460 (IC 50 = 2.8 µM) and HT29-MTX (IC 50 = 1.6 µM) cell lines, being much more active than the positive control podophyllotoxin (22 and 24 µM against these two cell lines, respectively) [ 58 ]. Compound 16 was also found to be active against A549 and SK-Br-3 cell lines, with a more potent effect than cisplatin ( Table 1 ), but is less potent against the HL60 cell-line [ 18 ].…”

Section: Biological Activities Exhibited By Secondary Metabolites mentioning

confidence: 99%

Phytochemicals with Added Value from Morella and Myrica Species

et al. 2020

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Terrestrial plants, due to their sessile nature, are highly exposed to environmental pressure and therefore need to produce very effective molecules that enable them to survive all the threats. Myrica and Morella (Myricaceae) are taxonomically close genera, which include species of trees or shrubs with edible fruits that exhibit relevant uses in traditional medicine. For instance, in Chinese or Japanese folk medicine, they are used to treat diarrhea, digestive problems, headache, burns, and skin diseases. A wide array of compounds isolated from different parts of Myrica and/or Morella species possess several biological activities, like anticancer, antidiabetic, anti-obesity, and cardio-/neuro-/hepatoprotective activities, both in vitro and in vivo, with myricanol, myricitrin, quercitrin, and betulin being the most promising. There are still many other compounds isolated from both genera whose biological activities have not been evaluated, which represents an excellent opportunity to discover new applications for those compounds and valorize Morella/Myrica species.

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Polysaccharides and Bioactive Phenolics from Aconitum septentrionale Roots

Malterud

Hamre

et al. 2023

Chemistry & Biodiversity

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Aconitum septentrionale is known to contain toxic diterpene alkaloids, while other bioactive compounds in the plant remain unclear. The aim of this study was to explore the phenolic compounds and polysaccharides from the water extract of A. septentrionale roots. Fifteen phenolic compounds were isolated and identified by NMR and MS, including fourteen known and one new dianthramide glucoside (2‐[[2‐(β‐D‐glucopyranosyloxy)‐5‐hydroxybenzoyl]amino]‐4,5‐dihydroxybenzoic acid methyl ester, 14). One neutral (complex of glucans with minor amounts of mannans) and two acidic polysaccharide fractions (complexes of pectic polysaccharides and glucans) were also obtained. Hydroxytyrosol (1), hydroxytyrosol‐1‐O‐β‐glucoside (2) and bracteanolide A (7) inhibited the release of nitric oxide by dendritic cells. Magnoflorine (8) and 2‐[[2‐(β‐D‐glucopyranosyloxy)‐5‐hydroxybenzoyl]amino]‐5‐hydroxybenzoic acid methyl ester (12) inhibited 15‐lipoxygenase, and bracteanolide A (7) was a moderate inhibitor of xanthine oxidase. This study is the first to describe the diversity of phenolics and polysaccharides from A. septentrionale and their anti‐inflammatory and anti‐oxidant activities.

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Bioactive triterpenoids and water-soluble melanin from Inonotus obliquus (Chaga) with immunomodulatory activity

Cited by 46 publications

References 38 publications

Improving growth properties and phytochemical compounds of Echinacea purpurea (L.) medicinal plant using novel nitrogen slow release fertilizer under greenhouse conditions

Improving growth properties and phytochemical compounds of Echinacea purpurea (L.) medicinal plant using novel nitrogen slow release fertilizer under greenhouse conditions

Phytochemicals with Added Value from Morella and Myrica Species

Polysaccharides and Bioactive Phenolics from Aconitum septentrionale Roots

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