Bioactive volatile organic compounds from Antarctic (sponges) bacteria

Papaleo, Maria Cristiana; Romoli, Riccardo; Bartolucci, Gianluca; Maida, Isabel; Perrin, Elena; Fondi, Marco; Orlandini, Valerio; Mengoni, Alessio; Emiliani, Giovanni; Tutino, Maria Luisa; Parrilli, Ermenegilda; Pascale, Donatella de; Michaud, Luigi; Giudice, Angelina Lo; Fani, Renato

doi:10.1016/j.nbt.2013.03.011

Cited by 57 publications

(33 citation statements)

References 19 publications

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“…These results are also in agreement with more recent works describing the ability of Pseudoalteromonas strains to completely inhibit the growth of human opportunistic pathogens belonging to the Burkholderia cepacia complex [55–57]. In those works the authors found that one of the most active Pseudoalteromonas strains was TB41, which is the only one able to produce a polyketide synthase that very likely contributes (in addition to other molecules of volatile nature) to its high inhibitory activity [55, 56].…”

Section: Resultssupporting

confidence: 93%

The pangenome of (Antarctic) Pseudoalteromonas bacteria: evolutionary and functional insights

et al. 2017

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Background Pseudoalteromonas is a genus of ubiquitous marine bacteria used as model organisms to study the biological mechanisms involved in the adaptation to cold conditions. A remarkable feature shared by these bacteria is their ability to produce secondary metabolites with a strong antimicrobial and antitumor activity. Despite their biotechnological relevance, representatives of this genus are still lacking (with few exceptions) an extensive genomic characterization, including features involved in the evolution of secondary metabolites production. Indeed, biotechnological applications would greatly benefit from such analysis.ResultsHere, we analyzed the genomes of 38 strains belonging to different Pseudoalteromonas species and isolated from diverse ecological niches, including extreme ones (i.e. Antarctica). These sequences were used to reconstruct the largest Pseudoalteromonas pangenome computed so far, including also the two main groups of Pseudoalteromonas strains (pigmented and not pigmented strains). The downstream analyses were conducted to describe the genomic diversity, both at genus and group levels. This allowed highlighting a remarkable genomic heterogeneity, even for closely related strains. We drafted all the main evolutionary steps that led to the current structure and gene content of Pseudoalteromonas representatives. These, most likely, included an extensive genome reduction and a strong contribution of Horizontal Gene Transfer (HGT), which affected biotechnologically relevant gene sets and occurred in a strain-specific fashion. Furthermore, this study also identified the genomic determinants related to some of the most interesting features of the Pseudoalteromonas representatives, such as the production of secondary metabolites, the adaptation to cold temperatures and the resistance to abiotic compounds.ConclusionsThis study poses the bases for a comprehensive understanding of the evolutionary trajectories followed in time by this peculiar bacterial genus and for a focused exploitation of their biotechnological potential.Electronic supplementary materialThe online version of this article (doi:10.1186/s12864-016-3382-y) contains supplementary material, which is available to authorized users.

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Section: Resultssupporting

confidence: 93%

The pangenome of (Antarctic) Pseudoalteromonas bacteria: evolutionary and functional insights

et al. 2017

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“…Haliclonissaverrucosa Burton, 1932 with vouchers MNA 915, MNA 916, MNA 917, MNA 918; Anoxycalyx (Scolymastra) joubini (Topsent, 1916) with voucher MNA 928; Lissodendoryx (Ectyodoryx) nobilis (Ridley & Dendy, 1886) with voucher MNA 863) were previously published in other manuscripts (i.e. Fondi et al 2014; Orlandini et al 2014; Papaleo et al 2013; 2012; Mangano et al 2009; Romoli et al 2011) without an MNA catalogue number which have been assigned after the publication. In the collection is also present an uncommon sponge (i.e.…”

Section: Taxonomic Coveragementioning

confidence: 99%

“…In total, the dataset includes 144 different morphospecies, and a total of 807 specimens. Several studies were based on this dataset: Alvizu et al (in press); Bertolino et al 2009; Calcinai et al 2000; Cattaneo-Vietti et al 2000; Fondi et al 2014; Mangano et al 2009; Orlandini et al 2014; Papaleo et al 2012, 2013; Romoli et al 2011; Sarà 2002; Sarà et al 1992. The validity and synonyms of each species name were checked in WORMS (World Register of Marine Species; http://www.marinespecies.org; last check made on 2018-03-28).…”

Section: Taxonomic Coveragementioning

confidence: 99%

Porifera collection of the Italian National Antarctic Museum (MNA), with an updated checklist from Terra Nova Bay (Ross Sea)

Ghiglione¹,

Alvaro²,

Cecchetto³

et al. 2018

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This new dataset presents occurrence data for Porifera collected in the Ross Sea, mainly in the Terra Nova Bay area, and curated at the Italian National Antarctic Museum (MNA, section of Genoa). Specimens were collected in 331 different sampling stations at depths ranging from 17 to 1,100 meters in the framework of 17 different Italian Antarctic expeditions funded by the Italian National Antarctic Research Program (PNRA). A total of 807 specimens, belonging to 144 morphospecies (i.e., 95 taxa identified at species level and 49 classified at least at the genus level) is included in the dataset. Nearly half (45%) of the species reported here correspond to species already known for Terra Nova Bay. Out of the remaining 55% previously unknown records, under a third (~29%) were classified at the species level, while over a quarter (~26%) were ascribed to the genus level only and these would require further study. All vouchers are permanently curated at the MNA and are available for study to the scientific community. A 3D model of an uncommon species from the Ross Sea, i.e. Tethyopsisbrondstedi (Burton, 1929), is also presented and will be made available for outreach purposes.

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“…Consequently, it could be hypothesized that plant-associated bacteria may interact each other also by using antibiotic molecules, suggesting that plant-associated bacteria could indeed be a source for new antibiotics and antibiotic resistance mechanisms, which can then spread in diverse environments by bacterial mobilization and (horizontal) gene transfer [10]. Indeed, bacterial communities associated with multicellular organisms have been claimed as a new source for antibiotics [23,24] and, recently, antibiotic resistance and bioactive molecule production were also reported for bacterial isolates medicinal plant species [22,1]. However, it is still not clear if antibiotic resistance is a common phenotype, not linked to environmental colonization, viz.…”

Section: Introductionmentioning

confidence: 99%

Antibiotic resistance differentiates Echinacea purpurea endophytic bacterial communities with respect to plant organs

Mengoni

Maida

Chiellini³

et al. 2014

Research in Microbiology

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Bioactive volatile organic compounds from Antarctic (sponges) bacteria

Cited by 57 publications

References 19 publications

The pangenome of (Antarctic) Pseudoalteromonas bacteria: evolutionary and functional insights

The pangenome of (Antarctic) Pseudoalteromonas bacteria: evolutionary and functional insights

Porifera collection of the Italian National Antarctic Museum (MNA), with an updated checklist from Terra Nova Bay (Ross Sea)

Antibiotic resistance differentiates Echinacea purpurea endophytic bacterial communities with respect to plant organs

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