Bioactives from stems and leaves of mung beans ( Vigna radiata  L.)

Bai, Yan; Yan, Xu; Chang, Jiawei; Wang, Xiaoxue; Zhao, Yunli; Yu, Zhiguo

doi:10.1016/j.jff.2016.06.009

Cited by 26 publications

(6 citation statements)

References 32 publications

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“…The IC 50 value of isoflavonoids isolated from the leaves of Smilax china L. against DPP4 is greater than 100 µM ( 4 ); thus, the DPP4 inhibitory activity of lupinalbin A (IC 50 , 45.2 µM) is stronger than these isoflavonoids. Moreover, Bai et al ( 20 ) reported that lignans and flavonoids isolated from mung beans exhibited inhibitory activity against α-glucosidase, and lupinalbin A, a type of isoflavonoid was shown to be more potent in their study compared with the present study, with an IC 50 value of 10.73±2.01 µM. Taken together, lupinalbin A isolated from A. americana inhibited the activity of DPP4 and α-glucosidase.…”

Section: Discussionsupporting

confidence: 51%

“…In our previous study, it was reported that lupinalbin A isolated from A. americana exhibits anti-inflammatory effects in LPS-induced RAW264.7 cells ( 19 ). Lupinalbin A has also been shown to possess an inhibitory effect against α-glucosidase ( 20 ). Nonetheless, the mechanism underlying the inhibition of α-glucosidase by lupinalbin A and the molecular interactions of lupinalbin A with DPP4 are not fully understood.…”

Section: Introductionmentioning

confidence: 99%

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Anti‑diabetic effect of the lupinalbin A compound isolated from Apios americana: In vitro analysis and molecular docking study

Kim

Jeong

et al. 2021

Biomed Rep

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Section: Discussionsupporting

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Anti‑diabetic effect of the lupinalbin A compound isolated from Apios americana: In vitro analysis and molecular docking study

Kim

Jeong

et al. 2021

Biomed Rep

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“…The results obtained from in vitro and animal studies indicated that the mung bean and its extracts possessed the ability to modulate glucose metabolism effectively (Table 3 and Table 4). Aqueous and ethanolic extracts of the mung bean showed a consequential inhibitory effect on the starch-hydrolyzing enzymes, such as gastrointestinal α-amylase (pancreatic) and α-glycosidase (intestinal) [35,45,64]. This may contribute toward reducing the intestinal absorption of carbohydrates, enhancing insulin sensitivity, and thus reducing body hyperglycemia.…”

Section: Health Benefitsmentioning

confidence: 99%

Mung Bean (Vigna radiata L.): Bioactive Polyphenols, Polysaccharides, Peptides, and Health Benefits

et al. 2019

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Mung bean (Vigna radiata L.) is an important pulse consumed all over the world, especially in Asian countries, and has a long history of usage as traditional medicine. It has been known to be an excellent source of protein, dietary fiber, minerals, vitamins, and significant amounts of bioactive compounds, including polyphenols, polysaccharides, and peptides, therefore, becoming a popular functional food in promoting good health. The mung bean has been documented to ameliorate hyperglycemia, hyperlipemia, and hypertension, and prevent cancer and melanogenesis, as well as possess hepatoprotective and immunomodulatory activities. These health benefits derive primarily from the concentration and properties of those active compounds present in the mung bean. Vitexin and isovitexin are identified as the major polyphenols, and peptides containing hydrophobic amino acid residues with small molecular weight show higher bioactivity in the mung bean. Considering the recent surge in interest in the use of grain legumes, we hope this review will provide a blueprint to better utilize the mung bean in food products to improve human nutrition and further encourage advancement in this field.

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“…Several studies have reported the isolation of lupinalbin A, a type of flavonoid, from Apios , Flemingia , white lupin, mung bean, and Eriosema laurentii de Wild, and it has been found to show osteoblast differentiation-promoting, anti-proliferative, antioxidant, estrogenic, and aryl hydrocarbon receptor agonistic activities [ 26 , 27 , 28 , 29 , 30 , 31 ]. Particularly, estrogen has been reported to have anti-inflammatory effects [ 32 ], and estrogen receptor (ER) activity is an important step in the inflammatory responses [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Effect of Lupinalbin A Isolated from Apios americana on Lipopolysaccharide-Treated RAW264.7 Cells

Kim

So³

et al. 2018

Molecules

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Apios americana, a leguminous plant, is used as food in some countries. Although the biological activities of Apios extract have been reported, there have been no reports about the anti-inflammatory mechanism of lupinalbin A on the RAW264.7 cells. In this study, we investigated the anti-inflammatory effect of A. americana lupinalbin A on lipopolysaccharide (LPS)-treated RAW264.7 cells. Lupinalbin A significantly inhibited nitric oxide production and inducible nitric oxide synthase expression in LPS-treated RAW264.7 cells. The expression of cytokines, including interleukin-6, tumor necrosis factor-α, and chemokine of monocyte chemoattractant protein, was reduced under lupinalbin A exposure in LPS-treated RAW264.7 cells. In addition, lupinalbin A significantly decreased LPS-induced interferon (IFN)-β production and STAT1 protein levels in RAW264.7 cells. Taken together, these results suggest that A. americana lupinalbin A exerts anti-inflammatory effects via the inhibition of pro-inflammatory cytokines and blocking of IFN-β/STAT1 pathway activation.

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Bioactives from stems and leaves of mung beans ( Vigna radiata L.)

Cited by 26 publications

References 32 publications

Anti‑diabetic effect of the lupinalbin A compound isolated from Apios americana: In vitro analysis and molecular docking study

Anti‑diabetic effect of the lupinalbin A compound isolated from Apios americana: In vitro analysis and molecular docking study

Mung Bean (Vigna radiata L.): Bioactive Polyphenols, Polysaccharides, Peptides, and Health Benefits

Anti-Inflammatory Effect of Lupinalbin A Isolated from Apios americana on Lipopolysaccharide-Treated RAW264.7 Cells

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