Bioactivities and Future Perspectives of Chaetoglobosins

Chen, Jinhua; Zhang, Wenzhou; Guo, Qingfeng; Yang, Yuedong; Zhang, Yongna

doi:10.1155/2020/8574084

Cited by 21 publications

(18 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Among the new compounds not produced by the WT strain, we found a wide range of chaetoglobosins as well as compounds that could be members of the cytochalasan alkaloid family. The production of several chaetoglobosins has already been detected in different isolates of P. expansum [ 13 ] and these compounds have a wide range of biological activities, including antitumor, antifungal, or antibacterial properties [ 91 ].…”

Section: Discussionmentioning

confidence: 99%

The brlA Gene Deletion Reveals That Patulin Biosynthesis Is Not Related to Conidiation in Penicillium expansum

Zetina-Serrano

Rocher

Naylies

et al. 2020

IJMS

View full text Add to dashboard Cite

Dissemination and survival of ascomycetes is through asexual spores. The brlA gene encodes a C2H2-type zinc-finger transcription factor, which is essential for asexual development. Penicillium expansum causes blue mold disease and is the main source of patulin, a mycotoxin that contaminates apple-based food. A P. expansum PeΔbrlA deficient strain was generated by homologous recombination. In vivo, suppression of brlA completely blocked the development of conidiophores that takes place after the formation of coremia/synnemata, a required step for the perforation of the apple epicarp. Metabolome analysis displayed that patulin production was enhanced by brlA suppression, explaining a higher in vivo aggressiveness compared to the wild type (WT) strain. No patulin was detected in the synnemata, suggesting that patulin biosynthesis stopped when the fungus exited the apple. In vitro transcriptome analysis of PeΔbrlA unveiled an up-regulated biosynthetic gene cluster (PEXP_073960-PEXP_074060) that shares high similarity with the chaetoglobosin gene cluster of Chaetomium globosum. Metabolome analysis of PeΔbrlA confirmed these observations by unveiling a greater diversity of chaetoglobosin derivatives. We observed that chaetoglobosins A and C were found only in the synnemata, located outside of the apple, whereas other chaetoglobosins were detected in apple flesh, suggesting a spatial-temporal organization of the chaetoglobosin biosynthesis pathway.

show abstract

Section: Discussionmentioning

confidence: 99%

The brlA Gene Deletion Reveals That Patulin Biosynthesis Is Not Related to Conidiation in Penicillium expansum

Zetina-Serrano

Rocher

Naylies

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…Chaetoglobosins, which are a large class of secondary metabolites that are cytochalasin alkaloids, have been isolated mainly from the fungus Chaetomium globosum [59]. Three previously known chaetoglobosins, chaetoglobosin Fex (41), G (42), and B (43), and one new chaetoglobosin, cytoglobosin X (44), were isolated from the fungus Chaetomium globosum, associated with the sea cucumber A. japonicus, on Chengshantou Island, China [29].…”

Section: Alkaloidsmentioning

confidence: 99%

Culturable Microorganisms Associated with Sea Cucumbers and Microbial Natural Products

et al. 2021

View full text Add to dashboard Cite

Sea cucumbers are a class of marine invertebrates and a source of food and drug. Numerous microorganisms are associated with sea cucumbers. Seventy-eight genera of bacteria belonging to 47 families in four phyla, and 29 genera of fungi belonging to 24 families in the phylum Ascomycota have been cultured from sea cucumbers. Sea-cucumber-associated microorganisms produce diverse secondary metabolites with various biological activities, including cytotoxic, antimicrobial, enzyme-inhibiting, and antiangiogenic activities. In this review, we present the current list of the 145 natural products from microorganisms associated with sea cucumbers, which include primarily polyketides, as well as alkaloids and terpenoids. These results indicate the potential of the microorganisms associated with sea cucumbers as sources of bioactive natural products.

show abstract

“…This condition due to the Chaetomium sp. produces secondary metabolite compounds, including chaetoglobosin, which has broad biological activities including antifungal, antibacterial, phytotoxins, and nematicides (Li et al 2014;Chen et al 2020).…”

Section: The Ability Test Of Pathogenic Fungi To Multiply On Alternative Liquid Media Against Weeds In Plantamentioning

confidence: 99%

The use of alternative liquid media for propagation of pathogenic fungi and their effect on weeds

2021

View full text Add to dashboard Cite

Abstract. Soesanto L, Mugiastuti E, Manan A. 2021. The use of alternative liquid media for propagation of pathogenic fungi and their effect on weeds. Biodiversitas 22: 719-725. Weeds cause high yield losses and are controlled by chemical, physical and mechanical control. Weed pathogenic fungi could be used as a biological control agent. However, the propagation media of them are still a higher cost, therefore, the new alternative and inexpensive media for weed pathogenic fungi propagation are required. The propagation of weed pathogenic fungi in liquid media in-vitro used randomize completely design consisted of three pathogenic weed fungi, i.e., Chaetomium sp., Fusarium sp., and Curvularia lunata and three liquid media, i.e., PDB, rice washing water, and tofu liquid waste. The in-planta tests used split-plot design used weed pathogenic fungi multiplied in the best formula from in-vitro results (rice washing water) and control as the main plot and four weeds, i.e., Cyperus kyllingia, Cynodon dactylon, Portulaca oleracea, and Ageratum conyzoides as subplot. The variables observed were conidia density, incubation period, disease intensity, number of leaves, and weed height. The results showed that rice washing water and tofu liquid waste were suitable media for the propagation of the weed pathogenic fungi. Chaetomium sp. was virulent fungi against broad leaves weeds, especially A. conyzoides. This fungus can be promoted to manufacture organic herbicides against the weed.

show abstract

Bioactivities and Future Perspectives of Chaetoglobosins

Cited by 21 publications

References 56 publications

The brlA Gene Deletion Reveals That Patulin Biosynthesis Is Not Related to Conidiation in Penicillium expansum

The brlA Gene Deletion Reveals That Patulin Biosynthesis Is Not Related to Conidiation in Penicillium expansum

Culturable Microorganisms Associated with Sea Cucumbers and Microbial Natural Products

The use of alternative liquid media for propagation of pathogenic fungi and their effect on weeds

Contact Info

Product

Resources

About