Bioactivity and gene expression studies of an arbustive Mexican specie Acaciella angustissima (Timbe)

Vargas-Hernández, Mateo; Munguía-Fragozo, Perla V.; Cruz-Hernández, Andrés; Guerrero, Brenda; González-Chavira, Mario Martín; Feregrino-Pérez, Ana A.; Mendoza-Díaz, Sandra; Loarca-Piña, Guadalupe; Torres-Pacheco, Irineo; Hernández–Salazar, Marcelo; Guevara-González, Ramón Gerardo

doi:10.1016/j.indcrop.2013.11.018

Cited by 7 publications

(3 citation statements)

References 23 publications

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“…The results indicated that methanolic extracts of A. angustissima pods are a good source of polyphenolic compounds as shown in Table 1 . These results agree with those reported by Vargas-Hernández et al [ 14 ].…”

Section: Resultssupporting

confidence: 94%

Timbe (Acaciella angustissima) Pods Extracts Reduce the Levels of Glucose, Insulin and Improved Physiological Parameters, Hypolipidemic Effect, Oxidative Stress and Renal Damage in Streptozotocin-Induced Diabetic Rats

et al. 2018

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In Mexico one in 14 deaths are caused by diabetes mellitus (DM) or by the macro and microvascular disorders derived from it. A continuous hyperglycemic state is characteristic of DM, resulting from a sustained state of insulin resistance and/or a dysfunction of β-pancreatic cells. Acaciella angustissima is a little studied species showing a significant antioxidant activity that can be used as treatment of this disease or preventive against the complications. The objective of this study was to explore the effect of oral administration of A. angustissima methanol extract on physiological parameters of streptozotocin-induced diabetic rats. The results indicated a significant reduction in blood glucose levels, an increase in serum insulin concentration, a decrease in lipid levels and an improvement in the parameters of kidney damage by applying a concentration of 100 mg/Kg B.W. However, glucose uptake activity was not observed in the adipocyte assay. Moreover, the extract of A. angustissima displayed potential for the complementary treatment of diabetes and its complications likely due to the presence of bioactive compounds such as protocatechuic acid. This study demonstrated that methanol extract of Acacciella angustissima has an antidiabetic effect by reducing the levels of glucose, insulin and improved physiological parameters, hypolipidemic effect, oxidative stress and renal damage in diabetic rats.

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Section: Resultssupporting

confidence: 94%

Timbe (Acaciella angustissima) Pods Extracts Reduce the Levels of Glucose, Insulin and Improved Physiological Parameters, Hypolipidemic Effect, Oxidative Stress and Renal Damage in Streptozotocin-Induced Diabetic Rats

et al. 2018

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“…Furthermore, the study showed that the extracts possessed medium antimutagenic activity at concentrations below 0.625 mg/mL, however, at the concentrations of 0.625-5 mg/mL, a strong antimutagenic activity was observed. In addition, the extracts also displayed fungistatic activity against Fusarium oxysporum, Rhizoctonia solani and Phytophtora capsici [28].…”

Section: Medicinal Uses and Pharmacological Propertiesmentioning

confidence: 97%

“…Vargas-Hernández et al [28] investigated the methanolic extracts of A. angustissima pods for its antioxidant activity using1,1-diphenyl2-picrylhydrazyl (DPPH), 2,2-azinobis-3 ethylbenzothiazoline-6-sulfonic acid (ABTS), ferric reducing antioxidant power (FRAP); antimutagenic activity using Kado Micro-suspension assay; and antimicrobial activity using the in vitro antimicrobial assay. The study revealed that the methanol extracts of A. angustissima pods depicted significant antioxidant activity by DPPH and ABTS with the IC 50 values ranging from 349.1-364.6 µg/mL and 110.3-149.5 µg/mL, respectively, which was higher than the two controls; gallic acid (33.1 µg/mL for DPPH and 15.39 µg/mL for ABTS) and Trolox (104.2 µg/mL for DPPH and 43.90 µg/mL for ABTS).…”

Section: Medicinal Uses and Pharmacological Propertiesmentioning

confidence: 99%

Acaciella angustissima (Mill.) Brit. & Rose: Botanical Features, Distribution, Medicinal and Pharmacological Properties

Musara¹,

Aladejana²

2020

J. Pharm. Nutr. Sci.

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Acaciella angustissima (Mill.) Brit. & Rose is a multipurpose deciduous thornless shrub or small tree that belongs to the family Fabaceae and subfamily Mimosoideae. This study aimed to explore A. angustissima, a leguminous shrub with medicinal, ecological and industrial potential. A mixed-method approach, which included consolidating quantitative and qualitative research, was utilized to put together the review with the main focus being on sub-Saharan Africa. However, case studies and literature from South Africa were also utilized. A. angustissima is a good source of phenolic compounds. It is used to relieve painful toothache, rheumatism, skin lesions, bloody diarrhea and mucoid diarrhea. It also displays a mild antimicrobial effect and has the ability to inhibit growth in malignant tumors. The study acknowledged Acaciella angustissima as an important agroforestry tree species that improve the quality of life of resource-poor farmers, reducing poverty and promoting sustainability of the natural resources base and economic growth

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Suppression Subtractive Hybridization Versus Next-Generation Sequencing in Plant Genetic Engineering: Challenges and Perspectives

et al. 2015

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Suppression subtractive hybridization (SSH) is an effective method to identify different genes with different expression levels involved in a variety of biological processes. This method has often been used to study molecular mechanisms of plants in complex relationships with different pathogens and a variety of biotic stresses. Compared to other techniques used in gene expression profiling, SSH needs relatively smaller amounts of the initial materials, with lower costs, and fewer false positives present within the results. Extraction of total RNA from plant species rich in phenolic compounds, carbohydrates, and polysaccharides that easily bind to nucleic acids through cellular mechanisms is difficult and needs to be considered. Remarkable advancement has been achieved in the next-generation sequencing (NGS) field. As a result of progress within fields related to molecular chemistry and biology as well as specialized engineering, parallelization in the sequencing reaction has exceptionally enhanced the overall read number of generated sequences per run. Currently available sequencing platforms support an earlier unparalleled view directly into complex mixes associated with RNA in addition to DNA samples. NGS technology has demonstrated the ability to sequence DNA with remarkable swiftness, therefore allowing previously unthinkable scientific accomplishments along with novel biological purposes. However, the massive amounts of data generated by NGS impose a substantial challenge with regard to data safe-keeping and analysis. This review examines some simple but vital points involved in preparing the initial material for SSH and introduces this method as well as its associated applications to detect different novel genes from different plant species. This review evaluates general concepts, basic applications, plus the probable results of NGS technology in genomics, with unique mention of feasible potential tools as well as bioinformatics.

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Bioactivity and gene expression studies of an arbustive Mexican specie Acaciella angustissima (Timbe)

Cited by 7 publications

References 23 publications

Timbe (Acaciella angustissima) Pods Extracts Reduce the Levels of Glucose, Insulin and Improved Physiological Parameters, Hypolipidemic Effect, Oxidative Stress and Renal Damage in Streptozotocin-Induced Diabetic Rats

Timbe (Acaciella angustissima) Pods Extracts Reduce the Levels of Glucose, Insulin and Improved Physiological Parameters, Hypolipidemic Effect, Oxidative Stress and Renal Damage in Streptozotocin-Induced Diabetic Rats

Acaciella angustissima (Mill.) Brit. & Rose: Botanical Features, Distribution, Medicinal and Pharmacological Properties

Suppression Subtractive Hybridization Versus Next-Generation Sequencing in Plant Genetic Engineering: Challenges and Perspectives

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