Bioactivity Guided Fractionation in Experimentally Induced Hyperlipidemia in Rats and Characterization of Phytoconstituent from Solanum nigrum

Sharma, Brajesh Kumar; Iyer, Deepa; Patil, U. K.

doi:10.1080/10496475.2012.688933

Cited by 4 publications

(2 citation statements)

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“…Polyphenols that are in S. nigrum might counter obesity and lead to lower levels of serum triglycerides, reduction in hepatic lipolysis, low-density lipoprotein (LDL)-cholesterol, and total cholesterol through their antilipogenetic effect [45]. Nevertheless, hyperlipidemic rats had their total cholesterol, LDL cholesterol, and triglyceride in serum increased, but HDL significantly decreased after being administered orally to an extracted plant [46]. The study found that Solanum nigrum, an ethanolic extract, significantly reduced cholesterol levels in rabbits with hyperlipidemia treated with lipofondin.…”

Section: Hmentioning

confidence: 99%

Overview of the Biochemical Potential of Solanum Nigrum

Abd alKhudhur salman

2024

UTJsci

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Solanum nigrum is known locally as the nightshadesamily, and it is considered one of the widespread plants that possess great biochemical potential. This review dealt with providing a comprehensive summary of the biochemistry of this plant, as it contains Solanum nigrum. It contains an important group of biologically active substances, including flavonoids, and some phenolic derivatives. It also contains some alkaloids, epoxy derivatives, and other important compounds. These substances have important biological activity, including significant and powerful antioxidant and anti-inflammatory properties, as well as strong antimicrobial and anti-cancer properties, and other medically important properties. This plant has been used for medicinal purposes for a long time in treating many diseases. Finally, this review indicates the wide biological diversity in biochemistry. The study also touched on some potential applications in various fields, including nutrition and medicine.

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Section: Hmentioning

confidence: 99%

Overview of the Biochemical Potential of Solanum Nigrum

Abd alKhudhur salman

2024

UTJsci

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“…Polyphenols derived from S. nigrum were reported to be an antiobesity agent, which could promote hepatic lipolysis, decrease serum triacylglyceride, cholesterol, and low-density lipoprotein (LDL)-cholesterol and inhibit lipogenesis ( Peng et al, 2020 ). In addition, the oral administration of an ethanolic extract or chloroform fraction of S. nigrum (200 and 400 mg/kg) for 5 days to triton-induced hyperlipidemic rats reversed the elevation of the serum of total cholesterol, triglycerides and LDL cholesterol level and the reduction of the HDL cholesterol level ( Sharma et al, 2012 ).…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Solanum nigrum Linn.: An Insight into Current Research on Traditional Uses, Phytochemistry, and Pharmacology

Chen¹,

Dai²,

Liu³

et al. 2022

Front. Pharmacol.

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Solanum nigrum Linn., is a common edible medicinal herb of the Solanaceae family which is native to Southeast Asia and is now widely distributed in temperate to tropical regions of Europe, Asia, and America. Traditionally, it has been used to treat various cancers, acute nephritis, urethritis, leucorrhea, sore throat, toothache, dermatitis, eczema, carbuncles, and furuncles. Up to now, 188 chemical constituents have been identified from S. nigrum. Among them, steroidal saponins, alkaloids, phenols, and polysaccharides are the major bioactive constituents. Investigations of pharmacological activities of S. nigrum revealed that this edible medicinal herb exhibits a wide range of therapeutic potential, including antitumor, anti-inflammatory, antioxidant, antibacterial, and neuroprotective activities both in vivo and in vitro. This article presents a comprehensive and systematic overview of the botanical, traditional uses, phytochemical compositions, pharmacological properties, clinical trials, and toxicity of S. nigrum to provide the latest information for further exploitation and applications of S. nigrum in functional foods and medicines.

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Plant Bioresources and their Nutrigenomic Implications on Health

Ismail

Imam

2014

Novel Plant Bioresources

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Bioactivity Guided Fractionation in Experimentally Induced Hyperlipidemia in Rats and Characterization of Phytoconstituent from Solanum nigrum

Cited by 4 publications

References 6 publications

Overview of the Biochemical Potential of Solanum Nigrum

Overview of the Biochemical Potential of Solanum Nigrum

Solanum nigrum Linn.: An Insight into Current Research on Traditional Uses, Phytochemistry, and Pharmacology

Plant Bioresources and their Nutrigenomic Implications on Health

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