Bioadhesive and formulation parameters affecting nasal absorption

Dondeti, Polireddy; Zia, Hossein; Needham, Thomas E.

doi:10.1016/0378-5173(95)04115-x

Cited by 76 publications

(40 citation statements)

References 72 publications

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“…Metered-dose nebulizers and metered-dose aerosols are superior to other devices in terms of accuracy and reproducibility (Dondeti 1996). However, the duration and condition of storage, as well as the physicochemical characteristics of the formulation such as viscosity, surface tension and homogeneity (e.g.…”

Section: Factors That Influence Nasal Drug Absorptionmentioning

confidence: 99%

“…Nasal mucoadhesive drug delivery has been under active investigation due to the peculiar advantages of the nasal cavity, in particular the opportunity to formulate controlled-release dosage forms (Ugwoke 1999 ;Ugwoke et al 1999a, b). The types of polymers used to improve the nasal bioavailability of several drugs and the levels of improved bioavailability obtained have been comprehensively reviewed elsewhere (Kamath & Park 1994 ;Dondeti et al 1996).…”

Section: Mucoadhesive Drug Deliverymentioning

confidence: 99%

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The biopharmaceutical aspects of nasal mucoadhesive drug delivery

Ugwoke

Verbeke

Kinget

2001

Journal of Pharmacy and Pharmacology

301

158

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Nasal drug administration has frequently been proposed as the most feasible alternative to parenteral injections. This is due to the high permeability of the nasal epithelium, allowing a higher molecular mass cut-off at approximately 1000 Da, and the rapid drug absorption rate with plasma drug profiles sometimes almost identical to those from intravenous injections.Despite the potential of nasal drug delivery, it has a number of limitations. In this review, the anatomy and physiology of the nasal cavity, as well as ciliary beating and mucociliary clearance as they relate to nasal drug absorption, are introduced. The rationale for nasal drug delivery and its limitations, some factors that influence nasal drug absorption, and the experimental models used in nasal drug delivery research are also reviewed. Nasal mucoadhesion as a promising method of nasal absorption enhancement is discussed, and factors that influence mucoadhesion, as well as safety of nasal mucoadhesive drug delivery systems are reviewed in detail.Nasal drug administration is presently mostly used for local therapies within the nasal cavity.

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Section: Factors That Influence Nasal Drug Absorptionmentioning

confidence: 99%

Section: Mucoadhesive Drug Deliverymentioning

confidence: 99%

The biopharmaceutical aspects of nasal mucoadhesive drug delivery

Ugwoke

Verbeke

Kinget

2001

Journal of Pharmacy and Pharmacology

301

158

View full text Add to dashboard Cite

show abstract

“…Several approaches have been used to evaluate in vitro interaction between mucin and mucoadhesive systems and for measuring the mucoadhesive potential of candidate delivery platforms [2]. One such approach is to determine the adhesive strength between the polymer and the attached substrate.…”

Section: Introductionmentioning

confidence: 99%

“…The compact diameter was 13 mm providing a theoretical surface contact area of 1.33 cm 2 . Given the possibility of different surface porosities between the top and bottom surfaces, the same surface (bottom) of the compressed polymer discs was used in all mucoadhesion experiments.…”

Section: Preparation Of Polymer Compactsmentioning

confidence: 99%