Bioavailability of nanoemulsions modified with curcumin and cerium dioxide nanoparticles

Abstract

In this work, the physicochemical properties and biological activity of nanoemulsions prepared from paraffin oil and stabilized by nonionic surfactants as carriers of curcumin and cerium dioxide nanoparticles were studied. An analysis of the results showed that curcumin was incorporated into the oil droplets while cerium dioxide nanoparticles were adsorbed on the surface of oil droplets. The nanoemulsion droplet size did not exceed 100 nm. The absence of toxicity to mouse embryonic fibroblasts in vitro and after a single intraperitoneal injection to mice in vivo makes the nanoemulsions promising drug carriers for advanced biomedical applications.KEYWORDS nanoemulsions, drug delivery, curcumin, cerium dioxide nanoparticles. ACKNOWLEDGEMENTS This research has been supported by the Russian Science Foundation (project 22-63-00082).

Cerium oxide@silica core-shell nanocomposite as multimodal platforms for drug release and synergistic anticancer effects

“…This makes CeNPs a unique multifunctional nanozyme and expands the scope of its future biomedical applications [6][7][8]. Moreover, it is known that CeNPs increases the bioavailability of a number of biologically active compounds, for example, curcumin [9], and also provides selective redox activity of widely used therapeutic agents for example, doxorubicin (DOX) [10,11].…”