Bioavailability Study of Maqui Berry Extract in Healthy Subjects

Abstract

Several health promoting effects have been reported for maqui berry, rich in anthocyanins. Direct effects of anthocyanins as well as bioactive metabolites might be involved. Within the study, bioavailability of a proprietary standardized maqui berry extract Delphinol® was investigated based on two selected anthocyanins (delphinidin-3-O-glucoside (DS) + cyanidin-3-O-sambubioside (CS)) and two breakdown products (protocatechuic acid (PCA) + gallic acid (GA)) after a single-dose supplementation in humans. Pharmacokinetic parameters were calculated from individual concentration time curves. In all 12 subjects a significant increase was noted in plasma values of DG and CS after intake of maqui berry extract. Maximum concentration of DG was observed after 1.0 ± 0.3 h and CS after 2.0 ± 1.1 h. Within 8 h, concentrations nearly returned to baseline levels. The results confirm a fast uptake and metabolism of the two selected key substances. Additionally, the phenolic acids GA and PCA were observed as breakdown products of anthocyanins. In summary, the study clearly confirms the bioavailability of maqui berry extract and its specific anthocyanin compounds and related breakdown products in healthy subjects.

Maqui berry extract prevents cigarette smoke induced oxidative stress in human osteoblasts in vitro

“…Low concentrations of MBE had no negative effect on hOBs cell viability and did not increase the ROS level. Among the tested concentrations, 1.56 μg/mL MBE demonstrated the highest hOBs cell viability, which is consistent with the physiological concentrations in humans (Schon et al, 2018[ 45 ]). Based on this result, a concentration of 1.56 μg/mL MBE was determined to be used in subsequent experiments.…”

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

“…Once absorbed, polyphenols enter portal circulation and are metabolized in the liver. This first pass metabolism modifies the polyphenol structure and in consequence its bioavailability and bioactivity [ 415 , 416 ]. Finally, the conjugate metabolites reach the bloodstream and the target tissues [ 415 , 416 , 417 , 418 ].…”

A Delphinidin-Enriched Maqui Berry Extract Improves Bone Metabolism and Protects against Bone Loss in Osteopenic Mouse Models

“…In the present study, we used MBE powder (Delphinol ® ), prepared from fresh maqui berries by water extraction followed by purification on resin and standardized to contain >25% delphinidins and >35% total anthocyanins. A recent study using MBE powder showed that after a single-dose supplementation in humans, both native and metabolites of anthocyanins were found in their plasma, possibly indicating a higher bioavailability of MBE [50]. The present study using bone marrow precursor cells showed that MBE inhibited osteoclastogenesis dose-dependently at concentrations lower than cell toxicity through downregulating Nfatc1 and CtsK mRNA, which are known to be downstream genes of NF-κB.…”