Biobanking – the First Step to Successful Liquid Biopsy Experiments

Almáši, Martina; Ševčı́ková, Sabina; Penka, Miroslav; Krejčí, Marta; Adam, Zdeněk; Vrublová, Petra; Jelı́nek, Tomáš; Hájek, Roman

doi:10.14735/amko20172s9

Klin Onkol

2017

DOI: 10.14735/amko20172s9

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Biobanking – the First Step to Successful Liquid Biopsy Experiments

Martina Almáši¹,

Sabina Ševčı́ková²,

Miroslav Penka³

et al.

Abstract: A general problem in solving many research questions is the availability of a critical amount of specimens for statistical analysis. Obtaining critical amount of specimens of biological material can be quickly archived by cooperation of biobanks sharing both methodological standards and informations about the availability of samples for research projects.Key words: archiving - biological material - informed consent - multiple myeloma - plasma cells.

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A comprehensive overview of liquid biopsy applications in pediatric solid tumors

Janssen,

Lak,

Janda

et al. 2024

npj Precis. Onc.

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Liquid biopsies are emerging as an alternative source for pediatric cancer biomarkers with potential applications during all stages of patient care, from diagnosis to long-term follow-up. While developments within this field are reported, these mainly focus on dedicated items such as a specific liquid biopsy matrix, analyte, and/or single tumor type. To the best of our knowledge, a comprehensive overview is lacking. Here, we review the current state of liquid biopsy research for the most common non-central nervous system pediatric solid tumors. These include neuroblastoma, renal tumors, germ cell tumors, osteosarcoma, Ewing sarcoma, rhabdomyosarcoma and other soft tissue sarcomas, and liver tumors. Within this selection, we discuss the most important or recent studies involving liquid biopsy-based biomarkers, anticipated clinical applications, and the current challenges for success. Furthermore, we provide an overview of liquid biopsy-based biomarker publication output for each tumor type based on a comprehensive literature search between 1989 and 2023. Per study identified, we list the relevant liquid biopsy-based biomarkers, matrices (e.g., peripheral blood, bone marrow, or cerebrospinal fluid), analytes (e.g., circulating cell-free and tumor DNA, microRNAs, and circulating tumor cells), methods (e.g., digital droplet PCR and next-generation sequencing), the involved pediatric patient cohort, and proposed applications. As such, we identified 344 unique publications. Taken together, while the liquid biopsy field in pediatric oncology is still behind adult oncology, potentially relevant publications have increased over the last decade. Importantly, steps towards clinical implementation are rapidly gaining ground, notably through validation of liquid biopsy-based biomarkers in pediatric clinical trials.

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A comprehensive overview of liquid biopsy applications in pediatric solid tumors

Janssen,

Lak,

Janda

et al. 2024

npj Precis. Onc.

View full text Add to dashboard Cite

show abstract

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Biobanking – the First Step to Successful Liquid Biopsy Experiments

Cited by 1 publication

References 11 publications

A comprehensive overview of liquid biopsy applications in pediatric solid tumors

A comprehensive overview of liquid biopsy applications in pediatric solid tumors

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