BioCartilage: Background and Operative Technique

Abrams, Geoffrey D.; Mall, Nathan A.; Fortier, Lisa A.; Roller, Brandon L.; Cole, Brian J.

doi:10.1053/j.otsm.2013.03.008

Cited by 60 publications

(47 citation statements)

References 56 publications

(53 reference statements)

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“…To date, an overall beneficial effect has been observed in more than 1,000 patients implanted with BioCartilage, with no adverse events related to this therapy. 4 Augmented microfracture technique is contraindicated in uncontained, diffuse chondral lesions and in joints with advanced degenerative arthritis. Patients with other copathology of the shoulder, such as glenohumeral instability, should undergo concomitant treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Animal studies support covering the microfractured area with micronized allograft cartilage tissue to serve as a scaffold to promote chondrogenesis and hyaline-like tissue formation. 4 The purpose of this article is to describe an arthroscopic technique of implanting micronized allogeneic cartilage scaffold, BioCartilage (Arthrex, Naples, FL), to treat an isolated osteochondral lesion of the glenoid (Fig 1 and Video 1). …”

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confidence: 99%

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Treatment of Glenoid Chondral Defect Using Micronized Allogeneic Cartilage Matrix Implantation

Shin

Mellano

Cvetanovich

et al. 2014

Arthroscopy Techniques

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Focal chondral lesions of the glenohumeral joint, though less common than chondral defects in the knee or ankle, can be a significant source of pain in an active population. For patients in whom nonsurgical management fails, promising results have been reported after arthroscopic microfracture surgery to treat such lesions. However, microfracture leads to growth of fibrocartilage tissue and is biomechanically less durable than native hyaline cartilage. Recently, augmentation of the microfractured defect with micronized allogeneic cartilage and platelet-rich plasma has been described to restore hyaline-like cartilage and potentially protect the subchondral bone from postsurgical fracture biology within the base of the defect. We present a simple arthroscopic technique of implanting dehydrated, micronized allogeneic cartilage scaffold to treat an isolated chondral lesion of the glenoid.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Treatment of Glenoid Chondral Defect Using Micronized Allogeneic Cartilage Matrix Implantation

Shin

Mellano

Cvetanovich

et al. 2014

Arthroscopy Techniques

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“…12,13 Techniques that incorporate drilling, microfracture, or abrasion chondroplasty result in the formation of fibrocartilage within the OCD lesion. 6 Because of poor long-term outcomes with less durable fibrocartilage, multiple authors have promoted autologous osteochondral transfer. 14 Unfortunately, osteochondral autograft typically requires an open approach to the elbow and knee, with considerable donor-site morbidity.…”

Section: Discussionmentioning

confidence: 99%

“…15 An optimal technique would comprise the simplicity of an arthroscopic approach and the capacity to generate a more hyaline-like cartilage without donor-site morbidity. 6 In an effort to promote a more hyaline-like cartilage fill within the OCD lesion, we propose the use of BioCartilage to supplement marrow stimulation 6 ( Table 3). The addition of a micronized allogeneic cartilage scaffold has been shown to yield higher rates of hyaline cartilage formation in animal studies when compared with microfracture alone.…”

Section: Discussionmentioning

confidence: 99%

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Arthroscopic Treatment of Capitellum Osteochondritis Dissecans With Micronized Allogeneic Cartilage Scaffold

Caldwell

Auerbach

Pearson

2017

Arthroscopy Techniques

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Osteochondritis dissecans (OCD) of the capitellum is a common disorder that causes pain and functional limitation in the adolescent elbow. Although conservative management is the first line of treatment, surgical intervention is usually recommended for patients with persistent mechanical symptoms, loose bodies, or unstable lesions. Elbow arthroscopy has become the gold standard to evaluate and treat symptomatic OCD lesions. Arthroscopic debridement and bone marrow stimulation have been shown to yield good short-term results. Unfortunately, long-term follow-up has shown less favorable outcomes, with degenerative changes frequently documented. Current marrow stimulation techniques promote the formation of fibrocartilage, which is known to be less durable than hyaline cartilage. We describe an arthroscopic technique of debridement and drilling supplemented with a micronized allogeneic cartilage scaffold to address OCD lesions of the capitellum in an effort to promote hyaline cartilage formation.

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Bioprinting Complex Cartilaginous Structures with Clinically Compliant Biomaterials

Kesti

Eberhardt²,

Pagliccia

et al. 2015

Adv Funct Materials

198

149

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wileyonlinelibrary.comwith rapid production of patient-specifi c grafts, allowing precise control over internal and external architecture and customized mechanical properties. These techniques can be used for printing biological materials together with living cells, hence the term "bioprinting." 3D bioprinting offers researchers a unique way of depositing cell-laden biocompatible materials, the so-called bioinks, in high-resolution structures with a line thickness on the order of hundreds of microns. Due to the promise of such a technology, several commercial bioprinters have entered the market and bioinks are the subject of intense investigation. [1][2][3] Bioink formulation is often considered one of the most critical aspects of high-resolution cellular bioprinting.Cellular printing requires a bioink with two key properties, namely printability and cytocompatible crosslinking. The identifi cation of printable polymeric systems is mainly done through rheological evaluation of a material's shear thinning behavior and shear recovery. Shear thinning correlates directly with a bioink's ability to be extruded at low pressure (<3 bar), something which ensures high postprinting cell viability. [ 4 ] Shear recovery, on the other hand, relates to the ink's resistance to fl ow after printing, which ensures high fi delity of the printed structure. The presence of cells, however, greatly restricts the crosslinking options as physiologic temperature and pH need to be maintained and harsh chemicals avoided. Hydrogel bioinks can be crosslinked via covalent or physical interactions or a combination thereof. Ultraviolet light initiated crosslinking of (meth)acrylated polymers has been used most often in bioinks, but the presence of potentially toxic monomers and photoinitiators may complicate clinical translation. [5][6][7][8] Physically crosslinked gelation based on temperature, hydrophobic/hydrophilic or ionic interactions has been utilized for precrosslinking of several bioink materials including poly( N -isopropylacrylamide) conjugated hyaluronan (HA-pNIPAAm), [ 9 ] gelatin, [ 10,11 ] alginate, [ 12 ] and gellan. [ 13 ] Precrosslinking before printing or directly during deposition to stabilize the printed lines is generally followed by a fi nal crosslinking which further increases the mechanical properties and stabilizes the whole structure.For cartilage engineering applications, natural polymers from animal or plant sources including alginate, collagen, gelatin, Bioprinting is an emerging technology for the fabrication of patient-specifi c, anatomically complex tissues and organs. A novel bioink for printing cartilage grafts is developed based on two unmodifi ed FDA-compliant polysaccharides, gellan and alginate, combined with the clinical product BioCartilage (cartilage extracellular matrix particles). Cell-friendly physical gelation of the bioink occurs in the presence of cations, which are delivered by co-extrusion of a cation-loaded transient support polymer to stabilize overhanging structures. Rheological properties of...

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BioCartilage: Background and Operative Technique

Cited by 60 publications

References 56 publications

Treatment of Glenoid Chondral Defect Using Micronized Allogeneic Cartilage Matrix Implantation

Treatment of Glenoid Chondral Defect Using Micronized Allogeneic Cartilage Matrix Implantation

Arthroscopic Treatment of Capitellum Osteochondritis Dissecans With Micronized Allogeneic Cartilage Scaffold

Bioprinting Complex Cartilaginous Structures with Clinically Compliant Biomaterials

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