2024
DOI: 10.1002/adsc.202400285
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Biocatalytic Recycling Cascades Combining Aldolases and Transaminases for the Stereo‐Controlled Synthesis of γ‐Hydroxy‐α‐Amino Acids

Léa Gourbeyre,
Jules Perrard,
Stephany Bouzid
et al.

Abstract: Abstract. Recycling cascades combining aldolases and transaminases from biodiversity were designed for the stereoselective synthesis of various isomers of γ‐hydroxy‐α‐amino acids. Aldolases with opposite enantioselectivities were combined with a D‐α‐transaminase to prepare in a single step, D‐syn or D‐anti‐4‐hydroxyglutamic acid with high yield and stereoselectivity. Bioactive (2S,3R,4S)‐4‐hydroxy‐isoleucine was also efficiently prepared via an aldolase‐transaminase recycling cascade. In that case, the unexpe… Show more

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