Biochemical activities of lactose-derived prebiotics — a review

Nath, Arijit; Mondal, Subhoshmita; Csighy, Attila; Molnár, Máté András; Pásztorné-Huszár, Klára; Kovács, Zoltán; Kőris, András; Vatai, Gyula

doi:10.1556/066.2017.46.4.7

Cited by 18 publications

(8 citation statements)

References 39 publications

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“…Different types of lactose-derivatives, such as galacto-oligosaccharide, lactosucrose, tagatose, lactulose, lactitol, lactobionic acid, and gluconic acid are produced through different enzymatic reactions (hydrolysis, transgalactosylation, isomerization, fructosyl-transfer, reduction, and oxidation), and microbial fermentation processes. They fulfill all criteria to become a member in the prebiotics family [7,8]. Lactose-based prebiotics are confirmed as ‘safe’ by the Food and Drug Administration Federal agency [9] and have unique biochemical importance [7,8,10].…”

Section: Introductionmentioning

confidence: 99%

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Biological Activities of Lactose-Based Prebiotics and Symbiosis with Probiotics on Controlling Osteoporosis, Blood-Lipid and Glucose Levels

et al. 2018

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Lactose-based prebiotics are synthesized by enzymatic- or microbial- biotransformation of lactose and have unique functional values. In this comprehensive review article, the biochemical mechanisms of controlling osteoporosis, blood-lipid, and glucose levels by lactose-based prebiotics and symbiosis with probiotics are reported along with the results of clinical investigations. Interaction between lactose-based prebiotics and probiotics reduces osteoporosis by (a) transforming insoluble inorganic salts to soluble and increasing their absorption to gut wall; (b) maintaining and protecting mineral absorption surface in the intestine; (c) increasing the expression of calcium-binding proteins in the gut wall; (d) remodeling osteoclasts and osteoblasts formation; (e) releasing bone modulating factors; and (f) degrading mineral complexing phytic acid. Lactose-based prebiotics with probiotics control lipid level in the bloodstream and tissue by (a) suppressing the expressions of lipogenic- genes and enzymes; (b) oxidizing fatty acids in muscle, liver, and adipose tissue; (c) binding cholesterol with cell membrane of probiotics and subsequent assimilation by probiotics; (d) enzymatic-transformations of bile acids; and (e) converting cholesterol to coprostanol and its defecation. Symbiosis of lactose-based prebiotics with probiotics affect plasma glucose level by (a) increasing the synthesis of gut hormones plasma peptide-YY, glucagon-like peptide-1 and glucagon-like peptide-2 from entero-endocrine L-cells; (b) altering glucose assimilation and metabolism; (c) suppressing systematic inflammation; (d) reducing oxidative stress; and (e) producing amino acids. Clinical investigations show that lactose-based prebiotic galacto-oligosaccharide improves mineral absorption and reduces hyperlipidemia. Another lactose-based prebiotic, lactulose, improves mineral absorption, and reduces hyperlipidemia and hyperglycemia. It is expected that this review article will be of benefit to food technologists and medical practitioners.

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Section: Introductionmentioning

confidence: 99%

“…They fulfill all criteria to become a member in the prebiotics family [7,8]. Lactose-based prebiotics are confirmed as ‘safe’ by the Food and Drug Administration Federal agency [9] and have unique biochemical importance [7,8,10]. Because of these reasons, medical practitioners frequently prescribe them as therapeutics.…”

Section: Introductionmentioning

confidence: 99%

Biological Activities of Lactose-Based Prebiotics and Symbiosis with Probiotics on Controlling Osteoporosis, Blood-Lipid and Glucose Levels

et al. 2018

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“…Benaissa et al (2017) evaluaron el suero de leche dulce como medio base para el cultivo de bacterias de ácido láctico y su efecto sobre las características tecnológicas de los lactobacilos, lo que presenta la oportunidad de desarrollar un medio de crecimiento bacteriano a bajo costo. Varios derivados de la lactosa, como la lactulosa, lactitol y lactosucrosa actúan como prebióticos y sus actividades bioquímicas se expresan en presencia de probióticos (Ugarte et al, 2011;Nath et al, 2017). También se ha demostrado que los galactooligosacáridos, componentes de la leche, son carbohidratos con actividad prebiótica que permiten cambios específicos en la composición y actividad de la microbiota intestinal responsable del bienestar y de la salud de su hospedador.…”

Section: Figura 1 Crecimiento De Lactobacillus Casei Shirota En Mediunclassified

Medios de Cultivos Complejos para la Cuantificación de Bacterias Ácido Lácticas

Sánchez

Rodríguez-Flores

Jiménez

et al. 2019

ESJ

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The content of lactic acid bacteria (LAB) is an important quality parameter in probiotic functional foods. Complex culture media formulated with natural additives are an alternative for their quantification. In this work we propose the use of orange, onion and jalapeño pepper juices, guava and noni pulps, as well as milk powder as ingredients of complex culture media for BAL quantification. The concentration of BAL recovered in the complex culture media and the commercial medium for lactobacilli De Man, Rogosa and Sharpe (MRS) were compared. No significant difference was found (P < 0.05) in BAL recovery between culture media made with orange juice (Log 9.33 ± 0.05 CFU/mL), guava pulp (Log 9.20 ± 0.10 CFU/mL), pulp noni (Log 9.12 ± 0.10 CFU/mL), milk powder (Log 9.10 ± 0.15 CFU/mL) and MRS (Log 9.20 ± 0.22 CFU/mL). However, the count was lower in the media added with onion and jalapeño pepper. Complex culture media are a simple, economical and quality alternative for the quantification of BAL in functional probiotic foods, such as fermented milk products and yogurt.

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“… Biochemical processes for the synthesis of different types of lactose-derived prebiotics and biological outcomes due to interactions between probiotics and lactose-derived prebiotics (self-developed, concepts were adopted from Nath et al, 2016 [ 3 ], Nath et al, 2017 [ 7 ] and Gänzle et al, 2008 [ 13 ]). …”

Section: Figurementioning

confidence: 99%

“…As the member of prebiotic family, they are resistant to gut enzymes of the upper tract, not absorbed in the gastrointestinal tract, selectively ferment, stimulate the growth and/or activity of one or limited bacteria (probiotics) in the intestine, as well as offer a number of health benefits to the consumer [ 3 , 4 , 5 ]. Lactose-derived prebiotics are of unique physico-chemical and bio-chemical importance [ 6 , 7 , 8 ] and they are confirmed as ‘safe’ by the Food and Drug Administration federal agency [ 9 ]. For these reasons, lactose-derived prebiotics are suggested for clinical purposes as therapeutics [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Biological Activities of Lactose-Derived Prebiotics and Symbiotic with Probiotics on Gastrointestinal System

et al. 2018

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Lactose-derived prebiotics provide wide ranges of gastrointestinal comforts. In this review article, the probable biochemical mechanisms through which lactose-derived prebiotics offer positive gastrointestinal health are reported along with the up-to-date results of clinical investigations; this might be the first review article of its kind, to the best of our knowledge. Lactose-derived prebiotics have unique biological and functional values, and they are confirmed as ‘safe’ by the Food and Drug Administration federal agency. Medical practitioners frequently recommend them as therapeutics as a pure form or combined with dairy-based products (yoghurt, milk and infant formulas) or fruit juices. The biological activities of lactose-derived prebiotics are expressed in the presence of gut microflora, mainly probiotics (Lactobacillus spp. in the small intestine and Bifidobacterium spp. in the large intestine). Clinical investigations reveal that galacto-oligosaccharide reduces the risks of several types of diarrhea (traveler’s diarrhea, osmotic diarrhea and Clostridium difficile associated relapsing diarrhea). Lactulose and lactosucrose prevent inflammatory bowel diseases (Crohn’s disease and ulcerative colitis). Lactulose and lactitol reduce the risk of hepatic encephalopathy. Furthermore, lactulose, galacto-oligosaccharide and lactitol prevent constipation in individuals of all ages. It is expected that the present review article will receive great attention from medical practitioners and food technologists.

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Biochemical activities of lactose-derived prebiotics — a review

Cited by 18 publications

References 39 publications

Biological Activities of Lactose-Based Prebiotics and Symbiosis with Probiotics on Controlling Osteoporosis, Blood-Lipid and Glucose Levels

Biological Activities of Lactose-Based Prebiotics and Symbiosis with Probiotics on Controlling Osteoporosis, Blood-Lipid and Glucose Levels

Medios de Cultivos Complejos para la Cuantificación de Bacterias Ácido Lácticas

Biological Activities of Lactose-Derived Prebiotics and Symbiotic with Probiotics on Gastrointestinal System

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