Biochemical and hematological parameters in chronic kidney disease

Singh, Sunita; Bhatta, Sushama

doi:10.3126/jmmihs.v4i1.21132

Cited by 8 publications

(14 citation statements)

References 6 publications

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“…Elevated creatinine and urea levels are likely evidence of decreased kidney function (5) . Bagalad et al (17) ,de Almeida et al (18) , Dash et al (19) and several studies done earlier also in agreement with our results and found that urea and creatinine were highly elevated in CKD patients prior dialysis and eventually decreased due to hemodialysis and there was a significant fall in serum creatinine level after hemodialysis as compared with pre-dialysis patients (20) . During hemodialysis, excess urea from the patient's blood is slightly removed in order to prevent accumulation.…”

Section: Figure 6: Correlation Between Fetuin-a and S Creatinine In Ckd Patients After Dialysissupporting

confidence: 93%

Evaluation of Serum Level of Cystatin C and Fetuin A in Patients with Chronic Renal Failure

Marwa Nabeel Hameed,

Khudhair A. Khudhair,

Yasir I. abbas

2021

Indian Journal of Forensic Medicine & Toxicology

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The study found that, serum fetuin-A was significantly reduced in CKD patients before dialysis (19.07±4.24 ng/ml) as compared with healthy individuals (22.5±5.94 ng/ml), P<0.01 and in CKD patients after dialysis (19.74±4.25 ng/ml) as compared with healthy individuals. The study found that, serum cystatin C was significantly reduced in CKD patients before dialysis (12.95±1.54 ng/ml) as compared with healthy individuals (8.16±2.37 ng/ml), P<0.01 and in CKD patients after dialysis (12.39±1.66 ng/ml) as compared with healthy individuals. The study showed a significant negative correlation between CKD patients before dialysis and after dialysis regarding cystatine C (r: -0.37). The study found that, blood urea was significantly increased in CKD patients before dialysis (164.3±30.1 mg/dl) as compared with healthy individuals (24.9±3.7 mg/dl), P<0.01 and in CKD patients after (76.1±29.2 mg/dl) as compared with healthy individuals and there was a significant difference in B. urea between CKD patients before and after dialysis (P<0.01). The study also indicated that S. creatinine was significantly increased in CKD patients before dialysis (5.61±1.99 mg/dl) followed by patients after dialysis (3.43±1.47 mg/dl) as compared with healthy individuals (0.57±0.24 mg/ dl) (P<0.01). The study showed a significant negative correlation between of Fetuin-A level with B. urea, S. creatinine and S. cysteine in CKD patients before dialysis and after dialysis

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Section: Figure 6: Correlation Between Fetuin-a and S Creatinine In Ckd Patients After Dialysissupporting

confidence: 93%

Evaluation of Serum Level of Cystatin C and Fetuin A in Patients with Chronic Renal Failure

Marwa Nabeel Hameed,

Khudhair A. Khudhair,

Yasir I. abbas

2021

Indian Journal of Forensic Medicine & Toxicology

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“…These values are lower than the control group, which is statistically significant change (p<0.5). Similar result are mentioned in other studies in chronic kidney disease patients, as mentioned from Singh et. al., 2018, Habib et al 2017, Suresh et al 2012, Yassein et al 2016and Alghythan et al, 2013.…”

Section: Figure 2 Etiology Of Chronic Kidney Diseasesupporting

confidence: 92%

“…It is noticed that males are more affected by chronic kidney disease and maintained on dialysis when compared to females as shown in table 1. Similar data are presented in other studies of the same profile, showing a predominance of male compared to female as mentioned bySingh et al 2018and Islam et al 2015and by Ansari et al 2021. From the data distribution we can see that the more problematic age is from 50 to 69 years old as shown in table1 and figure 1.…”

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confidence: 90%

Biochemical and Hematological Parameters in a Group of Chronic Kidney Disease Patients in Albania

Rumano¹,

Elezi²,

Rumano³

2021

EPHELS

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Chronic kidney disease is a serious, life threating health problem. It is also known as chronic kidney failure, as it is a process of irreversible loss of nephrons, which at the end stage leads to kidney failure. There are many different reasons that lead to kidney failure, such as: hypertension, diabetes, polycystic kidney disease, glomerulonephritis, parathyroid glands dysfunction, etc. The aim of this study was to evaluate the biochemical and hematological profile in a group of chronic kidney patients in Albania. A group of 247 chronic kidney disease patients is included in this study (170 adult males and 77 adult females). A group of biochemical parameters, such as urea, CRP, albuminemia, HbA1C, creatinine, ALT, AST, calcium, phosphate, CaxP product, sodium, potassium and hematological parameters, such as hemoglobin, red blood cells, white blood cells and PTH, where measured and compared to the findings from the control group. Results were analyzed statistically using SPSS 20 program for windows. From data analysis, we found a reduced count of red blood cells and hemoglobin, statistically significant change, compared to the control group (p0.05). High levels of PTH, serum urea, creatinine and hyperphosphatemia, accompanied by hypocalcemia, were found statistically significant compared to the control group (p0.05). From our observations, hypertension, diabetes and kidney stones were the main causes leading to chronic kidney disease. Evaluation of these parameters, results to be significant in the differentiation and management of the health state of these patients.

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“…The reduction in the synthesis of erythropoietin related to renal failure is the main reason for this abnormality. Other factors such as increased hemolysis, inflammation, chronic blood loss, nutritional deficiency, hyperparathyroidism, and marrow suppression can also contribute to the disease severity [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Homocysteine and Gamma-Glutamyl Transferase Concentrations As Markers of Chronic Kidney Disease: An Indian Perspective

Shyamkrishnan¹,

Saharia²,

Panda³

et al. 2022

Cureus

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BackgroundChronic kidney disease (CKD) involves a gradual loss of kidney function over months to years. Oxidative stress plays a critical role in the pathogenesis of CKD. Homocysteine (Hcy), an amino acid derivative, is a known risk factor for oxidative stress and endothelial damage. Gamma-glutamyl transferase (GGT), an enzyme abundant on the cell surface of liver and kidney cells, is raised during oxidative stress. The objectives of this study were to estimate the concentrations of serum Hcy and GGT among CKD patients and healthy controls and to determine whether there is an association between serum Hcy and GGT levels in CKD. MethodologyA total of 246 participants were needed to meet the calculated sample size. A total of 123 CKD patients meeting the inclusion and exclusion criteria were recruited as cases from the Nephrology outpatient department of our institute. Equal numbers of age-and sex-matched healthy volunteers were recruited as controls. Biophysical profiling of participants was done. Baseline investigations were recorded. A blood sample was collected from each participant and analyzed for GGT and Hcy along with other routine parameters. ResultsHcy and GGT concentrations were significantly high in CKD patients compared to healthy controls. There was a significant positive correlation between serum GGT and Hcy levels (r = 0.357). ConclusionsElevated levels of GGT and Hcy in CKD patients compared to healthy controls demonstrated the oxidative stress associated with the disease. GGT and Hcy can be used as prognostic markers of the disease.

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Biochemical and hematological parameters in chronic kidney disease

Cited by 8 publications

References 6 publications

Evaluation of Serum Level of Cystatin C and Fetuin A in Patients with Chronic Renal Failure

Evaluation of Serum Level of Cystatin C and Fetuin A in Patients with Chronic Renal Failure

Biochemical and Hematological Parameters in a Group of Chronic Kidney Disease Patients in Albania

Evaluation of Homocysteine and Gamma-Glutamyl Transferase Concentrations As Markers of Chronic Kidney Disease: An Indian Perspective

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