Biochemical and Karyotypic Variation in Peromyscus maniculatus from Western North America

Calhoun, Stuart W.; Greenbaum, Ira F.; Fuxa, Kathleen P.

doi:10.2307/1381745

Cited by 13 publications

(9 citation statements)

References 26 publications

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“…Peromyscus species are known to be relatively good swimmers (Sheppe 1965) and are considered to be rather good dispersers (Stickel 1968;Sullivan 1977;Ashley and Wills 1987;Calhoun et al 1988). Because the mice are active all winter long, dispersal can also occur while the lake is frozen, although migrations are limited at this time of the year (Fairbairn 1977(Fairbairn , 1978Wolff and Durr 1986).…”

Section: Resultsmentioning

confidence: 99%

The genetic heterogeneity of deer mouse populations (Peromyscus maniculatus) in an insular landscape

Landry

Lapointe

1999

Population Ecology

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A survey of the genetic variability in deer mouse populations was performed using specimens collected from six different islands on a lake covering approximately 50 km 2 . Random amplified polymorphic DNA (RAPD) was used to measure the extent of the genetic differences in this insular system. An analysis of molecular variance (AMOVA) revealed that populations are clearly separated at this microgeographic scale (F st ϭ 0.13863; P Ͻ 0.001). The homogeneity of molecular variance test (HOMOVA) indicated that within-population levels vary greatly (B p ϭ 0.76831; P Ͻ 0.001). The within-population molecular variance was found to be mainly correlated with the accessibility of the islands, computed as the inverse of the geographic distance separating an island from the lakeshore (r ϭ 0.916; P Ͻ 0.003).

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Section: Resultsmentioning

confidence: 99%

The genetic heterogeneity of deer mouse populations (Peromyscus maniculatus) in an insular landscape

Landry

Lapointe

1999

Population Ecology

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“…-Starch-gel electrophoresis was used to examine allozymic variation for 12 proteins encoded by 21 presumptive gene loci. Procedures for preparation of tissues (heart, liver, and kidney) and gels for electrophoretic analysis followed Calhoun et al (1988), Richardson Vo!' 74,No.4 et aL (1986), and Selander et aL (1971).…”

Section: Methodsmentioning

confidence: 99%

Systematic and Taxonomic Implications of Karyotypic, Electrophoretic, and Mitochondrial-Dna Variation in Peromyscus from the Pacific Northwest

Hogan

Hedin

Koh³

et al. 1993

Journal of Mammalogy

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Chromosomes, allozymes, and mitochondrial DNA (mtDNA) were analyzed to examine the taxonomic and systematic relationships of coastal Peromyscus from northern Washington to southern Alaska. All three datasets indicate that Peromyscus from this region constitute two distinct groups. One group comprises P. oreas, P. sitkensis, and several currently recognized subspecies of P. maniculatus including P. m. algidus, P. m. hylaeus, P. m. keeni, P. m. macrorhinus, and P. m. prevostensis. The second group comprises only populations of P. m. austerus. The. former group is differentiated from the latter by number of autosomal arms, allele-frequency differences, and mtDNA haplotypes. This dichotomy in karyotype, and the level of allozymic and mtDNA divergence between the groups suggest that the groups constitute distinct species. We recommend that P. oreas, P. sitkensis, P. maniculatus algidus, P. m. hylaeus, P. m. keeni, P. m. macrorhinus, and P. m. prevostensis be recognized under the specific epithet of Peromyscus keeni.The taxonomy of deer mice (Peramyscus) inhabiting the Pacific Northwest from Washington to southern Alaska has been complicated by extensive insular endemism resulting in a plethora of recognized taxa. Hall (1981) recognized two species in this region,P. maniculatusandP. sitkensis. From the Columbia River north to southern Alaska and west of the Cascade and Coastal mountain ranges, P. maniculatus was considered to comprise 27 subspecies distributed over the entire mainland and on most of the associated islands (Hall, 1981). Despite considerable evidence supporting the specific status of P. areas (Dice, 1949; J ohnson and Ostenson, 1959; Liu, 1954; Sheppe, J. Mamm., 74(4):819-831,1993 819 1961), Hall (1981) retained the taxon as a subspecies of P. maniculatus. Gunn andGunn (1988) reexamined the systematic status of areas and concluded that it is distinct from sympatric populations of P. m. austerus.These taxa can be discretely separated based on the number of autosomal arms (fundamental number, FN) in the karyotype. Populations of P. areas are characterized by a high FN (85-92), whereas P. m. austerus has a low FN (74-78). The absence of intermediate FNs in areas of sympatry was interpreted to indicate reproductive isolation.The specific status of P. areas has been further supported by morphologic (Allard and

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“…Peromyscus maniculatus (commonly known as ‘the’ deer mouse) is part of a species complex consisting of a series of partially interfertile populations/species; this group is particularly widespread, diverse, and amenable to genetic analyses (Note that this and several other Peromyscus groups complicate species definitions) . It is also within this group that the majority of resource development has occurred.…”

Section: What Are Peromyscus?mentioning

confidence: 99%

Peromyscus (deer mice) as developmental models

Vrana

Shorter

Szalai

et al. 2013

WIREs Developmental Biology

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Deer mice (Peromyscus) are the most common native North American mammals, and exhibit great natural genetic variation. Wild-derived stocks from a number of populations are available from the Peromyscus Genetic Stock Center (PGSC). The PGSC also houses a number of natural variants and mutants (many of which appear to differ from Mus). These include metabolic, coat-color/pattern, neurological, and other morphological variants/mutants. Nearly all these mutants are on a common genetic background, the Peromyscus maniculatus BW stock. Peromyscus are also superior behavior models in areas such as repetitive behavior and pair-bonding effects, as multiple species are monogamous. While Peromyscus development generally resembles that of Mus and Rattus, prenatal stages have not been as thoroughly studied, and there appear to be intriguing differences (e.g., longer time spent at the two-cell stage). Development is greatly perturbed in crosses between P. maniculatus (BW) and Peromyscus polionotus (PO). BW females crossed to PO males produce growth-restricted, but otherwise healthy, fertile offspring which allows for genetic analyses of the many traits that differ between these two species. PO females crossed to BW males produce overgrown but severely dysmorphic conceptuses that rarely survive to late gestation. There are likely many more uses for these animals as developmental models than we have described here. Peromyscus models can now be more fully exploited due to the emerging genetic (full linkage map), genomic (genomes of four stocks have been sequenced) and reproductive resources.

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Biochemical and Karyotypic Variation in Peromyscus maniculatus from Western North America

Cited by 13 publications

References 26 publications

The genetic heterogeneity of deer mouse populations (Peromyscus maniculatus) in an insular landscape

The genetic heterogeneity of deer mouse populations (Peromyscus maniculatus) in an insular landscape

Systematic and Taxonomic Implications of Karyotypic, Electrophoretic, and Mitochondrial-Dna Variation in Peromyscus from the Pacific Northwest

Peromyscus (deer mice) as developmental models

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