Biochemical and Molecular Genetic Predictors of Genital Prolapse

Abstract

Objective: To study the presence of gene polymorphisms of extracellular matrix structural components and metabolism enzymes, receptors activity and mechanisms of intracellular regulation of the connective tissue in women with genital prolapse.Subjects and methods: Analysis of published data on genetic polymorphisms and biochemical mechanisms of genital prolapse is presented. Results:The paper presents the morden data on the impact of genetic polymorphisms on genital prolapse predisposition. It describes appropriate molecular genetic and biochemical processes of pathological connective tissue formation of pelvic organs and the pelvic complex in women with genital prolapse. Conclusion:Genital prolapse is a multifactorial pathology with various pathological both extra-and intracellular mechanisms. At the moment, a lot of genetic variants are not specific only for this disease. There is no uniform consensus on the pathogenesis of the disease. Therefore, it is necessary to identify the specific molecular genetic markers of susceptibility to genital prolapse and identify high-risk groups, as well as the result prediction of surgical treatment.