Biochemical changes in the liver, kidney and serum of rat following chronic administration of cimetidine

Yakubu, Musa Toyin; Adesokan, AA; Akanji, Musbau Adewumi

doi:10.4314/ajbr.v9i3.48908

Cited by 23 publications

(26 citation statements)

References 16 publications

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“…Deficiencies in the activities of these markers mirror the degree of level of infection and toxicity of test compounds (Yakubu et al, 2006). It has been established that trypanosomal infection causes alteration in biomarker enzymes (Ekanem and Yusuf, 2005).…”

Section: Introductionmentioning

confidence: 99%

Effect of Methanol extract of Musca domestica larva on some Enzymes and Haematological parameters in Trypanosoma brucei brucei - infected rats

Shittu¹,

Lawal²,

Adeniyi³

et al. 2018

Nig J Bas App Sci

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This study investigated the effect of methanol extract of Musca domestica (400mg/kg body weight) on some biomarker enzymes and haematological parameters in Trypanosoma brucei brucei -infected rats. Twenty albino rats were intraperitoneally infected with Trypanosoma brucei brucei and were grouped into five (5) groups of four (4) rats each. Group1 was set up as infected not treated (0.2ml normal saline/kg body weight), group 2 was treated with diaminazene aceturate (standard drug), group 3 as prophylactic treated (treatment for 72 hours before inoculation of parasite), group 4 as early treatment with the extract (treatment commenced after the sight of parasite) and group 5 as the control (uninfected untreated) group. Results shows significant (p<0.05) decrease in liver AST and ALT activities with concomitant increase in serum activities of the infected untreated rats when compared with the early treated, prophylactic treated, standard treated and normal control. Serum ALP activity of the infected not treated group was significantly (p<0.05) higher when compared to the control group and other experimental groups. No significant (p>0.05) difference in the liver ALP activities of the extract treated infected groups with standard drug treated group However, serum and liver GGT activities of the uninfected untreated (control) was significantly lower (p<0.05) than all the other experimental groups. Haematological studies shows significant decrease (p<0.05) in packed cell volume (PCV) , haemoglobin concentration (Hb) and red blood cell count (RBC) of infected not treated when compared to infected prophylactic treated and infected early treated. There was likewise significant increase in white blood cell count (WBC) of infected not treated compared to infected prophylactic treated and infected early treated. Findings from this study showed that methanol extract of Musca domestica larva has trypanocidal properties thereby ameliorating the T. brucei induced biochemical changes in rats.

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Section: Introductionmentioning

confidence: 99%

Effect of Methanol extract of Musca domestica larva on some Enzymes and Haematological parameters in Trypanosoma brucei brucei - infected rats

Shittu¹,

Lawal²,

Adeniyi³

et al. 2018

Nig J Bas App Sci

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“…The method of Yakubu et al [11] was adopted for the preparation of serum. Briefly, under halothane anaesthesia, the neck area of the rats was quickly shaved to expose the jugular veins.…”

Section: Preparation Of Serummentioning

confidence: 99%

Antidiabetic and haematological effect of aqueous extract of stem bark of Afzelia africana (Smith) on streptozotocin–induced diabetic Wistar rats

Aiyegoro

et al. 2011

Asian Pacific Journal of Tropical Biomedicine

104

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“…A high blood level of urea and creatinine indicates that the kidneys may not be functioning properly and the drug might have interfered with creatinine metabolism that caused renal toxicity in mice 19,20 . A comparable renal toxicity was reported by Abdelmajeed (2009) Gulec et al, (2011) noted that chronically administered olanzapine and risperidone caused nephrotoxic effects in male rats.…”

Section: Discussionmentioning

confidence: 99%

Ameliorative Effect of Broccoli Powder on Renal Toxicity in Mice Caused by Continuous Exposure to Escitalopram Antidepressant Drug

Saxena¹,

Shahani²

2017

Int. Res. J. Pharm.

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Antidepressants induced metabolic syndrome is a major public health problem in the treatment of psychiatric disorders which leads to an increased risk of cardiovascular disease, non-alcoholic hepatic steatosis and renal dysfunction. Psychiatric disorder is a mental illness that includes depression, schizophrenia, and anxiety disorder that affect millions of people around the world. The purpose of present study was to investigate the protective role of broccoli powder against continuous ingestion of antidepressant drug induced nephrotoxicity in Swiss albino mice. In present study mice were continuously treated with escitalopram antidepressant drug (20 mg/kg/b.w. orally) for 4, 8 and 12 weeks. The escitalopram drug intoxicated group showed elevation in serum urea and creatinine level. Escitalopram drug intoxicated group also showed degeneration of glomerulus and renal tubule that are comparable with carbon tetrachloride (33 mg/kg) group considered as positive control. Group that received both broccoli powder and escitalopram drug (200 mg/kg + 20 mg/kg) significantly reduced elevated level of serum urea and creatinine with mild degeneration of glomerulus and renal tubule as compared to antidepressant drug intoxicated group.

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Biochemical changes in the liver, kidney and serum of rat following chronic administration of cimetidine

Abstract: ABSTRACT

Cited by 23 publications

References 16 publications

Effect of Methanol extract of <i>Musca domestica</i> larva on some Enzymes and Haematological parameters in <i>Trypanosoma brucei brucei</i> - infected rats

Effect of Methanol extract of <i>Musca domestica</i> larva on some Enzymes and Haematological parameters in <i>Trypanosoma brucei brucei</i> - infected rats

Antidiabetic and haematological effect of aqueous extract of stem bark of Afzelia africana (Smith) on streptozotocin–induced diabetic Wistar rats

Ameliorative Effect of Broccoli Powder on Renal Toxicity in Mice Caused by Continuous Exposure to Escitalopram Antidepressant Drug

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